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72 条记录 (耗时 0.047 秒)

    Indenoisoquinolinone analogs and methods of use thereof
    62.
    发明授权
    Indenoisoquinolinone analogs and methods of use thereof 失效
    茚并异喹啉酮类似物及其使用方法

    公开(公告)号：US07652028B2

    公开(公告)日：2010-01-26

    申请号：US11510484

    申请日：2006-08-23

    申请人： Prakash Jagtap ,  Duy-Phong Pham-Huu

    发明人： Prakash Jagtap ,  Duy-Phong Pham-Huu

    IPC分类号： A61K31/473 ,  C07D221/18

    CPC分类号： C07D491/048 ,  C07D221/18 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04

    摘要： The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog.

    摘要翻译： 本发明涉及茚并异喹啉酮类似物，包含有效量的茚并异喹啉酮类似物和治疗或预防炎性疾病，再灌注损伤，糖尿病，糖尿病并发症，器官移植引起的再氧化损伤，缺血状况， 神经变性疾病，肾衰竭，血管疾病，心血管疾病，癌症，早产儿并发症，心肌病，视网膜病变，肾病，神经病，勃起功能障碍或尿失禁，包括向有需要的受试者施用有效量的茚并异喹啉酮类似物 。

    Pyridyl-substituted porphyrin compounds and methods of use thereof
    65.
    发明授权
    Pyridyl-substituted porphyrin compounds and methods of use thereof 失效
    吡啶基取代的卟啉化合物及其使用方法

    公开(公告)号：US07432369B2

    公开(公告)日：2008-10-07

    申请号：US11090447

    申请日：2005-03-25

    申请人： William Williams ,  Garry Southan

    发明人： William Williams ,  Garry Southan

    IPC分类号： C07B47/00 ,  C07D487/22

    CPC分类号： C07D487/22 ,  C07F11/005 ,  C07F13/005 ,  C07F15/025

    摘要： The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.

    摘要翻译： 本发明涉及吡啶基取代的卟啉化合物，包含有效量的吡啶基取代的卟啉化合物的组合物和用于治疗或预防由于暴露于反应性物质引起的损伤，由于手术引起的勃起功能障碍，肺部疾病，高氧，神经变性 疾病，肝脏疾病，心脏停搏期间的心肌损伤，炎症状况，再灌注损伤，缺血状况，心血管疾病，糖尿病，糖尿病并发症，癌症，癌症化疗的副作用或辐射诱发的损伤，或 延长易氧化化合物的半衰期，包括向有需要的受试者施用有效量的吡啶基取代的卟啉化合物。

    Purine compounds and methods of use thereof
    66.
    发明申请
    Purine compounds and methods of use thereof 审中-公开
    嘌呤化合物及其使用方法

    公开(公告)号：US20070238694A1

    公开(公告)日：2007-10-11

    申请号：US11726572

    申请日：2007-03-22

    申请人： Andrew Salzman ,  Prakash Jagtap

    发明人： Andrew Salzman ,  Prakash Jagtap

    IPC分类号： A61K31/7076 ,  C07H19/20 ,  C07H19/19

    CPC分类号： C07H19/19 ,  C07H19/20

    摘要： The invention relates to Purine Compounds; compositions comprising an effective amount of a Purine Compound; and methods for reducing a subject's rate of metabolism or protecting a subject's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, diabetes, a cellular proliferative disorder, a skin disorder, a radiation-induced injury, a wound or an inflammatory disease comprising administering an effective amount of a Purine Compound to a subject in need thereof.

    摘要翻译： 本发明涉及嘌呤化合物; 包含有效量的嘌呤化合物的组合物; 以及减少受试者的代谢速率或保护受试者的心脏在心脏停搏期间对心肌损伤的方法; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病，糖尿病，细胞增殖性疾病，皮肤病，辐射诱导的损伤，伤口或炎性疾病 包括向有需要的受试者施用有效量的嘌呤化合物。

    Indenoisoquinolinone analogs and methods of use thereof
    69.
    发明申请
    Indenoisoquinolinone analogs and methods of use thereof 失效
    茚并异喹啉酮类似物及其使用方法

    公开(公告)号：US20070049555A1

    公开(公告)日：2007-03-01

    申请号：US11510484

    申请日：2006-08-23

    申请人： Prakash Jagtap ,  Duy-Phong Pham-Huu

    发明人： Prakash Jagtap ,  Duy-Phong Pham-Huu

    IPC分类号： A61K31/4743 ,  A61K31/4741 ,  A61K31/675

    CPC分类号： C07D491/048 ,  C07D221/18 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04

    摘要： The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog.

    摘要翻译： 本发明涉及茚并异喹啉酮类似物，包含有效量的茚并异喹啉酮类似物和治疗或预防炎性疾病，再灌注损伤，糖尿病，糖尿病并发症，器官移植引起的再氧化损伤，缺血状况， 神经变性疾病，肾衰竭，血管疾病，心血管疾病，癌症，早产儿并发症，心肌病，视网膜病变，肾病，神经病，勃起功能障碍或尿失禁，包括向有需要的受试者施用有效量的茚并异喹啉酮类似物 。