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    SYSTEM AND METHOD FOR APPLYING PLASMA SPARKS TO TISSUE
    61.
    发明申请
    SYSTEM AND METHOD FOR APPLYING PLASMA SPARKS TO TISSUE 有权
    用于将等离子体火花应用于组织的系统和方法

    公开(公告)号：US20100280513A1

    公开(公告)日：2010-11-04

    申请号：US12759853

    申请日：2010-04-14

    Applicant: Kolb F. Juergen ,  Scully Noah ,  Schoenbach H. Karl ,  Paithankar Dilip

    Inventor： Kolb F. Juergen ,  Scully Noah ,  Schoenbach H. Karl ,  Paithankar Dilip

    IPC: A61B18/14

    CPC classification number: A61B18/1477 ,  A61B18/1206 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/1213 ,  A61B2018/122

    Abstract: A pulse delivery system for producing a spark in tissue is disclosed. The system can include at least two electrodes having sharp surface features, where the at least two electrodes are electrically isolated from one another. The sharp features of the electrodes can be separated by a distance of about 2 to 20 mm. The system can also include a pulse generator for delivering pulsed voltage differences between the at least two electrodes. The pulsed voltage differences can producing a voltage difference ranging from about 2.5 kV to about 35 kV for a duration of about 50 ns to 3 μs. The system can include a controller for determining whether the plurality of pulsed voltage differences produced a spark between the at least two electrodes. A method of producing a spark in tissue for both therapeutic and cosmetic, i.e., non-therapeutic, applications is also disclosed.

    Abstract translation: 公开了一种用于在组织中产生火花的脉冲传送系统。 该系统可以包括具有尖锐表面特征的至少两个电极，其中至少两个电极彼此电隔离。 电极的尖锐特征可以分开约2至20毫米的距离。 该系统还可以包括用于在至少两个电极之间递送脉冲电压差的脉冲发生器。 脉冲电压差可以产生约2.5kV至约35kV的电压差，持续时间约为50ns至3μs。 该系统可以包括用于确定多个脉冲电压差是否在至少两个电极之间产生火花的控制器。 还公开了用于治疗和化妆品的组合中产生火花的方法，即非治疗性应用。

    Electrodeless excimer UV lamp
    64.
    发明授权
    Electrodeless excimer UV lamp 失效
    无电极准分子UV灯

    公开(公告)号：US06858988B1

    公开(公告)日：2005-02-22

    申请号：US10284113

    申请日：2002-10-30

    Applicant: Mounir Laroussi

    Inventor： Mounir Laroussi

    IPC: H01J7/24 ,  H01J65/00 ,  H01J65/04

    CPC classification number: H01J65/046

    Abstract: An electrodeless excimer UV lamp, comprising an enclosed chamber with a gas sealed within the enclosed chamber, wherein the gas is capable of being used to generate a plasma discharge, a first electrode wrapped around the outer surface of the chamber at a first location, a second electrode wrapped around the outer surface of the chamber at second location, and a power supply configured to apply a voltage to the first electrode and the second electrode. During operation of the UV lamp, a plasma discharge is generated by applying a voltage to the electrodes wrapped around the outer surface of the chamber to ignite the gas or gas mixture inside the chamber and generate a plasma discharge within the chamber, such that a specific wavelength of UV radiation will be generated by the particular gas within the chamber.

    Abstract translation: 一种无电极准分子UV灯，包括密封在封闭室内的气体的封闭室，其中气体能够用于产生等离子体放电，第一电极在第一位置周围缠绕在腔室的外表面上， 在第二位置处缠绕在腔室的外表面的第二电极，以及被配置为向第一电极和第二电极施加电压的电源。 在UV灯的操作期间，通过向围绕室的外表面缠绕的电极施加电压来产生等离子体放电，以点燃室内的气体或气体混合物，并在室内产生等离子体放电，使得特定 UV辐射的波长将由腔室内的特定气体产生。

    ELECTROPORATION-INDUCED ELECTROSENSITIZATION
    66.
    发明申请
    ELECTROPORATION-INDUCED ELECTROSENSITIZATION 有权

    公开(公告)号：US20210214712A1

    公开(公告)日：2021-07-15

    申请号：US17215773

    申请日：2021-03-29

    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

    Inventor： Olga Pakhomova ,  Andrei G. Pakhomov

    IPC: C12N13/00 ,  A61N1/32

    Abstract: Systems and methods of enhancing membrane permeabilization in a cell are provided. An example method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the systems and methods, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.

    Multi-electrode electrical pulse delivery system for treatment of biological tissues
    67.
    发明授权
    Multi-electrode electrical pulse delivery system for treatment of biological tissues 有权

    公开(公告)号：US10881447B2

    公开(公告)日：2021-01-05

    申请号：US15827875

    申请日：2017-11-30

    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

    Inventor： Karl Schoenbach ,  Richard Heller

    IPC: A61B18/14 ,  A61B18/12 ,  A61B18/00

    Abstract: Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.

    Ablation of myocardial tissues with nanosecond pulsed electric fields
    68.
    发明授权
    Ablation of myocardial tissues with nanosecond pulsed electric fields 有权

    公开(公告)号：US10786303B2

    公开(公告)日：2020-09-29

    申请号：US15885930

    申请日：2018-02-01

    Applicant: Old Dominion University Research Foundation

    Inventor： Christian W. Zemlin

    IPC: A61B18/14 ,  A61B18/00

    Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.

    VIDEO STREAMING AT MOBILE EDGE
    69.
    发明申请
    VIDEO STREAMING AT MOBILE EDGE 审中-公开

    公开(公告)号：US20200177652A1

    公开(公告)日：2020-06-04

    申请号：US16207260

    申请日：2018-12-03

    Applicant: AT&T Intellectual Property I, L.P.

    Inventor： Emir Halepovic ,  Ibrahim Ben Mustafa ,  Tamer Nadeem

    IPC: H04L29/06 ,  H04L12/853

    Abstract: Aspects of the subject disclosure may include, for example, a method comprising sending context information from a mobile wireless device through a control channel to a network server; receiving a policy at the mobile wireless device from the network server, wherein the policy assigns a video streaming bit rate to the mobile wireless device based on the context information; and implementing the policy to control a video streaming session between the mobile wireless device and a media server over a data channel. The context information may include information about the mobile wireless device and/or a user of the mobile wireless device. The policy may be different for each mobile wireless device. Other embodiments are disclosed.

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