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    ARG-GLY-ASP-CONJUGATED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME
    63.
    发明申请
    ARG-GLY-ASP-CONJUGATED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME 有权
    ARG-GLY-ASP-结合的阿尔法 - 梅毒素刺激性霍乱胶囊用于诊断和治疗MELANOMA，包括METASTATIC MELANOMA及其相关方法

    公开(公告)号：US20120107237A1

    公开(公告)日：2012-05-03

    申请号：US13321942

    申请日：2010-05-28

    申请人： Yubin Miao ,  Jianquan Yang

    发明人： Yubin Miao ,  Jianquan Yang

    IPC分类号： A61K51/08 ,  A61K38/21 ,  A61P35/00 ,  A61K38/20 ,  C07K7/64 ,  A61K38/12

    CPC分类号： C07K14/68 ,  A61K38/00 ,  A61K51/082 ,  A61K51/086 ,  A61K51/088 ,  C12N9/88

    摘要： The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

    摘要翻译： 本发明涉及新颖的非侵入性诊断和治疗工具/化合物，其包含利用环肽螯合基团的杂环环肽，其中所述化合物结合MSH受体以成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤 体内。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

    Peptide mimics of melanocyte stimulating hormone
    64.
    发明授权
    Peptide mimics of melanocyte stimulating hormone 有权
    促进黑素细胞激素的肽模拟

    公开(公告)号：US08080632B2

    公开(公告)日：2011-12-20

    申请号：US11991121

    申请日：2006-09-01

    申请人： Jesse Roth

    发明人： Jesse Roth

    IPC分类号： C07K14/245

    CPC分类号： C07K14/68 ,  A61K38/00 ,  Y02A50/385 ,  Y02A50/411 ,  Y02A50/473

    摘要： Provided are peptides having melanocyte stimulating hormone activity. Also provided are vectors encoding these peptides and transgenic cells comprising the above vectors. Additionally, methods of reducing or preventing release of an inflammatory cytokine from mammalian cells are provided, as are methods for treating a mammal suffering from, or at risk for, a condition mediated by an inflammatory cytokine cascade. Further provided are methods of reducing levels of an inflammatory cytokine in a mammal, methods of treating an overweight mammal, methods of decreasing food intake in a mammal and methods of inhibiting innate immunity in the digestive system of a mammal.

    摘要翻译： 提供了具有促进黑素细胞激素活性的肽。 还提供了编码这些肽的载体和包含上述载体的转基因细胞。 此外，提供了减少或预防来自哺乳动物细胞的炎性细胞因子释放的方法，以及用于治疗患有由炎性细胞因子级联介导的病症或具有风险的哺乳动物的方法。 还提供了减少哺乳动物炎症细胞因子水平的方法，治疗超重哺乳动物的方法，减少哺乳动物食物摄入的方法以及抑制哺乳动物消化系统中的先天免疫的方法。

    Bis-sulfhydryl macrocyclization systems
    65.
    发明授权
    Bis-sulfhydryl macrocyclization systems 有权
    双巯基大环化体系

    公开(公告)号：US07960506B2

    公开(公告)日：2011-06-14

    申请号：US11957325

    申请日：2007-12-14

    申请人： Huw M. Nash

    发明人： Huw M. Nash

    IPC分类号： C07K5/12 ,  C07K4/00

    CPC分类号： A61K38/12 ,  C07K1/1133 ,  C07K14/4747 ,  C07K14/68 ,  C07K14/705

    摘要： Peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production, are provided.

    摘要翻译： 提供拟肽大环化合物及其制备和使用方法，以及氨基酸类似物和大环化合物形成接头以及可用于其生产的试剂盒。

    Peptide mimics of melanocyte stimulating hormone
    69.
    发明申请
    Peptide mimics of melanocyte stimulating hormone 有权
    促进黑素细胞激素的肽模拟

    公开(公告)号：US20100048465A1

    公开(公告)日：2010-02-25

    申请号：US11991121

    申请日：2006-09-01

    申请人： Jesse Roth

    发明人： Jesse Roth

    IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P1/00 ,  A61P31/00 ,  A61P9/00 ,  A61P37/00 ,  A61P25/00 ,  A61P3/00

    CPC分类号： C07K14/68 ,  A61K38/00 ,  Y02A50/385 ,  Y02A50/411 ,  Y02A50/473

    摘要： Provided are peptides having melanocyte stimulating hormone activity. Also provided are vectors encoding these peptides and transgenic cells comprising the above vectors. Additionally, methods of reducing or preventing release of an inflammatory cytokine from mammalian cells are provided, as are methods for treating a mammal suffering from, or at risk for, a condition mediated by an inflammatory cytokine cascade. Further provided are methods of reducing levels of an inflammatory cytokine in a mammal, methods of treating an overweight mammal, methods of decreasing food intake in a mammal and methods of inhibiting innate immunity in the digestive system of a mammal.

    摘要翻译： 提供了具有促进黑素细胞激素活性的肽。 还提供了编码这些肽的载体和包含上述载体的转基因细胞。 此外，提供了减少或预防来自哺乳动物细胞的炎性细胞因子释放的方法，以及用于治疗患有由炎性细胞因子级联介导的病症或具有风险的哺乳动物的方法。 还提供了减少哺乳动物炎症细胞因子水平的方法，治疗超重哺乳动物的方法，减少哺乳动物食物摄取的方法以及抑制哺乳动物消化系统中先天免疫的方法。

    Peptides for Use in the Treatment of Obesity
    70.
    发明申请
    Peptides for Use in the Treatment of Obesity 审中-公开
    用于治疗肥胖症的肽

    公开(公告)号：US20080306008A1

    公开(公告)日：2008-12-11

    申请号：US11666800

    申请日：2005-11-04

    申请人： Ulrich Sensfuss ,  Leif Christensen

    发明人： Ulrich Sensfuss ,  Leif Christensen

    IPC分类号： C07K7/06 ,  A61K38/08 ,  A61P3/04 ,  A61P3/10

    CPC分类号： C07K7/56 ,  A61K38/00 ,  C07K14/68 ,  C07K14/72

    摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

    摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。