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公开(公告)号:US11471408B2
公开(公告)日:2022-10-18
申请号:US16875710
申请日:2020-05-15
IPC分类号: A61K9/06 , A61P17/04 , A61K47/10 , A61K47/14 , A61K31/203 , A61Q19/00 , A61K45/06 , A61K31/198 , A61K31/202
摘要: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.
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公开(公告)号:US20220323551A1
公开(公告)日:2022-10-13
申请号:US17628811
申请日:2020-06-29
发明人: Sang-Yun CHOI , Kwang-Il JUNG
IPC分类号: A61K38/44 , A61K31/192 , A61K31/198 , A61K31/575 , A61K31/4706 , A61K38/06 , A61K31/085 , A61K31/05 , A61K31/375 , A61K31/355 , A61K9/00 , A61P31/16
摘要: Disclosed is a composition for preventing, treating or ameliorating a viral infection disease, which is safe for human application since the safety of a reactive oxygen species production inhibitor and a reactive oxygen species scavenger has already been verified. The disclosure utilizes inversely the mechanism of viruses which induces oxidative damage of a host cell and then activates viral replication and infection. Although not having direct specificity to a specific virus like existing vaccines, the composition can effectively inhibit proliferation of all viruses including oxidative stress, regardless of virus type or mutations. It can be applied as a sub-universal infection inhibitor and therapeutic agent as a limited alternative to vaccines that must be newly developed each year due to emergence of new viruses or viral mutations, and is expected to be used as a preventive agent or auxiliary agent to prevent epidemics.
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公开(公告)号:US11466052B2
公开(公告)日:2022-10-11
申请号:US16092203
申请日:2017-03-31
申请人: VYTRUS BIOTECH, S.L.
发明人: Oscar Expósito Tarrés , Albert Jané Font , Sara Laplana Lasierra , Maria Mas Duarte , Tarik Ruiz Medina , Ana Gallego Palacios , Ana Belen Sabater Jara
IPC分类号: C07K7/06 , A61K38/07 , A61K38/08 , A61K31/047 , A61K31/197 , A61K31/198 , A61K31/375 , A61K31/401 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K33/06 , A61K33/26 , A61K33/30 , A61K33/34 , A61K36/9066 , A61K45/06 , C07K5/107 , A61K31/7076 , A23L33/18 , A23L33/175 , A23L33/16 , A23L33/15 , A61P17/14 , A61K31/194 , A61K31/4188 , A61K31/675 , A61K33/14 , C07K5/10
摘要: Present invention discloses particular peptide sequences of formula (I); (R1)(m)-Xaa1IXaa2T(Q)(p)(R2)(n) (I) (SEQ ID NO: 1); wherein R1, m, p, n, Xaa1, Xaa2, and R2 have particular meanings, or pharmaceutically or veterinary acceptable salts of these peptides that are effective in the prevention and/or treatment of mammal hair loss. Invention also relates to particular topical pharmaceutical, nutraceutical or veterinary compositions with the peptides of formula (I).
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公开(公告)号:US20220313673A1
公开(公告)日:2022-10-06
申请号:US17633699
申请日:2020-08-19
申请人: NEURORESERVE INC.
IPC分类号: A61K31/455 , A61K31/714 , A61K31/593 , A61K31/355 , A61K33/06 , A61K31/353 , A61K31/05 , A61K31/09 , A61K31/685 , A61K31/198 , A61P25/28 , A61P3/02 , A23L33/155 , A23L33/165 , A23L33/12
摘要: The dietary supplements of various embodiments comprise a water-soluble vitamin component, an oil-soluble vitamin component, magnesium or derivatives thereof, a primary polyphenolic compound, a secondary polyphenolic compound, and an omega-3-phospholipid complex. The methods include maintaining health, maintaining brain health and reducing the risk or rate of neurodegeneration or cognitive decline. Methods, including algorithms, for systematically determining a dietary supplement are also described.
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公开(公告)号:US11458115B2
公开(公告)日:2022-10-04
申请号:US17736494
申请日:2022-05-04
申请人: NeuroDerm, Ltd.
发明人: Tal Birnberg , Liat Adar , Itay Perlstein
IPC分类号: A61K31/198
摘要: Disclosed is a method for the treatment of a neurological or movement disorder, e.g., Parkinson's disease, in an individual in need thereof, by parenteral administration of levodopa and a dopa decarboxylase inhibitor (DDCI), such as carbidopa, benserazide or any combination thereof, concomitantly with oral administration of levodopa, a DDCI, such as carbidopa, benserazide, or any combination thereof.
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公开(公告)号:US11458114B2
公开(公告)日:2022-10-04
申请号:US16873603
申请日:2020-05-19
申请人: Alain Martin
发明人: Alain Martin
IPC分类号: A61K31/198 , A61K31/401 , A61P17/02 , A61K9/08 , A61K45/06
摘要: A method for, and medicinal composition for, treatment of mammalian cells for enhancing synthesis, secretion and transport of collagen to increase wound strength, that includes magnesium pyruvate; calcium pyruvate; L proline; citrulline: and a liquid carrier.
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公开(公告)号:US11458104B1
公开(公告)日:2022-10-04
申请号:US16562224
申请日:2019-09-05
发明人: Jon Taylor , Stuart Smoot , Stuart Schoenherr , Paul Werchan
IPC分类号: A61K9/28 , A61K31/198 , A61K9/20
摘要: A solid pharmaceutical composition is provided that includes a core, an inner coating, and an outer coating. The core includes tiopronin as an active agent. Further, the inner coating, which includes a cellulose-based polymer, surrounds the core, and the outer coating, which includes an enteric polymer, surrounds the inner coating. As a result of the specific components of the solid pharmaceutical composition, the solid pharmaceutical composition exhibits a fed state Cmax of tiopronin that is at least 70% of a 12-hour fasted state Cmax of tiopronin after oral administration of the solid pharmaceutical composition when administered as a 300 milligram dose. As such, it is possible for the solid pharmaceutical composition to be administered orally with or without food (e.g., in a fed or fasted state) while still achieving a desired maximum plasma concentration of the tiopronin in a delayed release formulation.
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公开(公告)号:US20220305085A1
公开(公告)日:2022-09-29
申请号:US17838461
申请日:2022-06-13
申请人: Verint Americas Inc.
发明人: Ian Roy Beaver
IPC分类号: A61K38/18 , A61K31/198 , A61K31/215 , A61K31/216 , A61K31/401 , A61K31/41 , G06N20/00 , G06F40/289
摘要: A system and method for updating computerized language models is provided that automatically adds or deletes terms from the language model to capture trending events or products, while maximizing computer efficiencies by deleting terms that are no longer trending and use of knowledge bases, machine learning model training and evaluation corpora, analysis tools and databases
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公开(公告)号:US20220296553A1
公开(公告)日:2022-09-22
申请号:US17832040
申请日:2022-06-03
发明人: Clarissa J. Nobile , Megha Gulati
IPC分类号: A61K31/198 , A61P31/04 , A61P31/10 , A61K31/133 , A61K31/401 , A61K31/405 , A61K31/4172 , A61K31/661 , A61K47/08
摘要: The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans.
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公开(公告)号:US20220288113A1
公开(公告)日:2022-09-15
申请号:US17693191
申请日:2022-03-11
IPC分类号: A61K33/26 , A61K33/00 , A61K31/198 , A61K31/405 , A61K31/4172 , A61K33/08 , A61K33/24 , A61K31/375 , A61K36/21
摘要: The disclosure is directed to methods of at least reducing nitrosamine formation, preventing formation of, or even reversing formation of, nitrosamines, improving athletic performance, and increasing aerobic capacity, stamina, muscle strength, endurance, and/or time to exhaustion in a subject. The disclosure is also directed to related compositions including a nitrate (source of nitrate anion NO3−) and/or a nitrite (source of nitrite anion NO2−), an amine moiety containing compound, and an elemental metal. In other implementations, the compositions may also include an acid.
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