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    USE OF KOUMINE AND ITS HOMOLOGUES IN PREPARATION OF MEDICAMENT FOR TREATMENT OF AUTOIMMUNE DISEASES OF INVOLVED BONES AND JOINTS
    61.
    发明申请
    USE OF KOUMINE AND ITS HOMOLOGUES IN PREPARATION OF MEDICAMENT FOR TREATMENT OF AUTOIMMUNE DISEASES OF INVOLVED BONES AND JOINTS 有权
    使用KOMMINE及其制备用于治疗涉及的血管和关节的自身免疫性疾病的药物

    公开(公告)号：US20150011767A1

    公开(公告)日：2015-01-08

    申请号：US14138978

    申请日：2014-07-16

    申请人： Fujian Medical University

    发明人： Changxi Yu ,  Ying Xu ,  Jian Yang ,  Yanping Su ,  Hongda Cai

    IPC分类号： A61K31/4748

    CPC分类号： A61K31/4748 ,  A61K31/439

    摘要： The present invention discloses an application of koumine and homologue thereof in preparation of drugs for treating autoimmune diseases involving bones and joints including rheumatoid arthritis, spondylitis ankylopoietica or the like, in particular an application of Gelsemium alkaloid monomer koumine and homologue thereof or pharmaceutically acceptable salt thereof as active ingredient in preparation of drugs for treating autoimmune diseases involving bones and joints including rheumatoid arthritis, spondylitis ankylopoietica or the like. The result of pharmacology experiment shows that koumine can decrease the generation of organism antibody against autoimmune diseases involving bones and joints in a dose dependent manner, improve symptoms of swelling and hyperalgesia, reduce arthritis index, reverse joint pathological changes, and has no serious shortage of commonly used clinical drugs; thus koumine has an effect against autoimmune diseases involving bones and joints including rheumatoid arthritis, ankylosing spondylitis etc. with strong potency and low toxicity. Koumine can be developed into a new drug for treating autoimmune disease involving bones and joints including rheumatoid arthritis, spondylitis ankylopoietica etc., which has a clear industrial prospect.

    摘要翻译： 本发明公开了一种应用于其制备用于治疗包括类风湿性关节炎，脊椎炎脊索炎等骨骼和关节在内的自身免疫性疾病的药物中的应用，特别是应用Gelsemium生物碱单体kumum及其同系物或其药学上可接受的盐 作为用于治疗涉及骨骼和关节的自身免疫性疾病的药物的制剂的活性成分，包括类风湿性关节炎，脊椎炎脊柱炎等。 药理实验结果表明，可以以剂量依赖的方式减少生物体抗体针对骨骼和关节的自身免疫性疾病的发生，改善肿胀症状和痛觉过敏症状，减少关节炎指数，逆转关节病理改变，并且不会严重缺乏 常用临床药物; 因此，对于涉及骨骼和关节的自身免疫性疾病，包括类风湿性关节炎，强直性脊柱炎等，具有强效力和低毒性，因此其具有效果。 可以开发出一种治疗自身免疫性疾病的新药，包括类风湿关节炎，脊髓炎脊髓炎等骨骼关节炎，具有明显的工业前景。

    Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
    67.
    发明授权
    Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction 失效
    用于预防，治疗或逆转神经元功能障碍的药物组合物和方法

    公开(公告)号：US08299062B2

    公开(公告)日：2012-10-30

    申请号：US10943502

    申请日：2004-09-17

    申请人： Franklin Volvovitz

    发明人： Franklin Volvovitz

    IPC分类号： A61K31/27 ,  A61K31/435 ,  A61K31/47 ,  A61K31/55 ,  A61K31/4353 ,  A61K31/4748 ,  A61K31/445 ,  A61K31/5513 ,  A61K31/551 ,  A61K31/216

    CPC分类号： A61K31/439 ,  A61K31/216 ,  A61K31/27 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/46 ,  A61K31/47 ,  A61K31/4748 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06 ,  Y02A50/465 ,  A61K2300/00

    摘要： The present invention provides compositions and methods for preventing, treating or reversing neuronal dysfunction in a mammal resulting from exposure to organophosphate nerve agents, organophosphate insecticides and incapacitating agents of the central nervous system (CNS); CNS injury, including traumatic brain injury, neurologic complications of cardiac surgery, perinatal asphyxia, and stroke, spinal cord injury, and peripheral nerve injury; and neuronal disorders associated with the loss of motor function including post-polio syndrome, amyotrophic lateral sclerosis, myasthenia gravis, Parkinson's disease and Rett syndrome; neurodegenerative disorders including Alzheimer's disease, mild cognitive impairment and schizophrenia; and cognitive impairment associated with aging. The compositions of the invention preferably comprise in effective amounts (a) at least one acetylcholinesterase inhibitor, (b) at least one compound with anticholinergic properties or both anticholinergic and antiglutamatergic properties, (c) optionally an anticonvulsive compound, and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供了用于预防，治疗或逆转由于暴露于有机磷酸盐神经剂，有机磷酸酯杀虫剂和中枢神经系统（CNS）的失能药物引起的哺乳动物的神经元功能障碍的组合物和方法; CNS损伤包括创伤性脑损伤，心脏手术神经并发症，围产期窒息和中风，脊髓损伤和周围神经损伤; 以及与运动功能丧失相关的神经元疾病，包括脊髓灰质炎综合征，肌萎缩性侧索硬化，重症肌无力，帕金森病和Rett综合征; 神经变性疾病包括阿尔茨海默病，轻度认知障碍和精神分裂症; 和与衰老相关的认知障碍。 本发明的组合物优选包含有效量的（a）至少一种乙酰胆碱酯酶抑制剂，（b）至少一种具有抗胆碱能特性或抗胆碱能药和抗谷氨酸能特性的化合物，（c）任选的抗惊厥药物和药学上可接受的载体。