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    Processes for producing 3-thia furans and 3-furan thiols
    64.
    发明授权
    Processes for producing 3-thia furans and 3-furan thiols 失效
    生产3-硫呋呋喃和3-呋喃硫醇的方法

    公开(公告)号：US3922288A

    公开(公告)日：1975-11-25

    申请号：US47836874

    申请日：1974-06-11

    申请人： INT FLAVORS & FRAGRANCES INC

    发明人： EVERS WILLIAM J ,  HEINSOHN JR HOWARD R ,  MAYERS BERNARD J

    IPC分类号： A23L27/20 ,  C07C45/59 ,  C07D307/32 ,  C07D307/64 ,  C07D307/68

    CPC分类号： C07D307/32 ,  A23L27/2052 ,  C07C45/59 ,  C07D307/64 ,  C07D307/68 ,  C07C49/203

    摘要： Processes for producing substituted or unsubstituted 3-thia furans and 3-furan thiols comprising the steps of: I. Providing a 2-ene-1,4 dione having the structure:

    II. Intimately admixing said 2-ene-1,4 dione with a thiol having the formula R3SH thereby providing a substituted or unsubstituted 2-thia substituted 1,4 dione having the structure:

    III. Cyclizing said 2-thia substituted 1,4 dione to form a substituted or unsubstituted 3-thia furan having the formula:

    IV. Optionally but only when R3 hydrolyzing is acyl or aroyl, said 3-thia furan thereby forming a 3-mercapto furan having the structure:

    V. Optionally, reacting said 3-mercapto furan with an acyl halide thereby forming a 3-thia furan having the formula:

    WHEREIN R1 and R2 are the same or different lower alkyl; wherein R3 is either acyl, aroyl, or alkyl; wherein R4 is hydrogen or lower alkyl; and wherein R5 is different from R3 and is either acyl or aroyl. If either of R1 or R2 are hydrogen, then step (ii) is performed in the presence of an organic base such as piperidine, pyridine, triethyl amine, quinoline, or Alpha picoline.

    摘要翻译： 制备取代或未取代的3-硫杂呋喃和3-呋喃硫醇的方法包括以下步骤：

    Hydroxycitric acid derivatives
    65.
    发明授权
    Hydroxycitric acid derivatives 失效
    羟基柠檬酸衍生物

    公开(公告)号：US3919254A

    公开(公告)日：1975-11-11

    申请号：US37647873

    申请日：1973-07-05

    申请人： HOFFMANN LA ROCHE

    发明人： GUTHRIE ROBERT WILLIAM ,  KIERSTEAD RICHARD WIGHTMAN

    IPC分类号： C07D493/04 ,  C07D307/32

    CPC分类号： C07D493/04

    摘要： Ester and amide derivatives of threo-hydroxycitric acid gamma lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.

    摘要翻译： 苏氨酸羟基柠檬酸γ-内酯的酯和酰胺衍生物抑制生物系统中的脂肪酸合成，并且可用于治疗肥胖症和纠正脂质异常的情况。

    Dihydro-5-hydroxy-4,4-dialkyl-3 (2h)-furanones
    67.
    发明授权
    Dihydro-5-hydroxy-4,4-dialkyl-3 (2h)-furanones 失效
    二氢-5-羟基-4,4-二烷基-3（2H） - 呋喃酮

    公开(公告)号：US3558664A

    公开(公告)日：1971-01-26

    申请号：US3558664D

    申请日：1969-02-12

    申请人： EASTMAN KODAK CO

    发明人： ROBINSON ALFRED G ,  BLOOD ALDEN E ,  HAGEMEYER HUGH J JR

    IPC分类号： C07D307/32 ,  C07D5/04

    CPC分类号： C07D307/32

    摘要： HYDROXY FURANONES HAVING THE GENERAL FORMULA

    4-R1,4-R2,5-HO-TETRAHYDROFURAN-3-ONE

    WHEREIN R1 AND R2 ARE SAME OR DIFFERENT ALKYL GROUPS OF 1 TO 10 CARBON ATOMS ARE PREPARED BY THERMAL DECOMPOSITION OF COMPOUNDS HAVING THE FORMULA

    2-(R1-CH(-R2)-),6-R1,6-R2-TETRAHYDROFURO(2,3-D)-1,3-

    DIOXOL-5-OL

    WHEREIN R1 AND R2 ARE AS PREVIOUSLY DESCRIBED. THE THERMAL DECOMPOSITION OF THE STARTING MATERIAL IS PREFERABLY EFFECTED AT A TEMPERATURE IN THE RANGE OF 120*C. TO 200*C. IN THE PRESENCE OF AN ALKALI METAL SALT OF AN ORGANIC ACID. THE HYDROXY FURANONES ARE USEFUL SOLVENTS AND INTERMEDIATES FOR THE PREPARATION OF POLYOLS USEFUL, FOR EXAMPLE, AS SOLVENTS AND IN THE MANUFACTURE OF POLYESTERS.

    Specification of functional cranial placode derivatives from human pluripotent stem cells
    70.
    发明授权
    Specification of functional cranial placode derivatives from human pluripotent stem cells 有权

    公开(公告)号：US11591567B2

    公开(公告)日：2023-02-28

    申请号：US16373026

    申请日：2019-04-02

    申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

    发明人： Stuart Chambers ,  Lorenz Studer ,  Zehra Dincer ,  Bastian Zimmer

    IPC分类号： C12N5/0793 ,  A61K35/12 ,  C07D211/00 ,  C07D307/32 ,  C07D243/36

    摘要： Cranial placodes are embryonic structures essential for sensory and endocrine organ development. The efficient derivation of cranial placodes from human pluripotent stem cells is disclosed where the timed removal of the BMP inhibitor Noggin, a component of the dual-SMAD inhibition strategy of neural induction, triggers placode induction at the expense of CNS fates. Further fate specification at the pre-placode stage enables the selective generation of placode-derived trigeminal ganglia capable of in vivo engraftment, mature lens fibers and anterior pituitary hormone-producing cells that upon transplantation produce hormones including, but not limited to, human growth hormone and adrenocortiocotropic hormone in vivo. Alternatively, anterior pituitary hormone-producing cells are generated in cell culture systems in vitro.