公开(公告)号：US08065021B2

公开(公告)日：2011-11-22

申请号：US11981301

申请日：2007-10-30

申请人： Yossi Gross ,  Shai Ayal ,  Ehud Cohen

发明人： Yossi Gross ,  Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/04

CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/36114

摘要： Apparatus is provided for applying current to a nerve. A cathode is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve and to apply a cathodic current to the nerve. A primary inhibiting anode is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve and to apply a primary anodal current to the nerve. A secondary inhibiting anode is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve and to apply a secondary anodal current to the nerve, the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.

摘要翻译： 提供用于向神经施加电流的装置。 阴极适于放置在神经的阴极纵向位置附近，并将阴极电流施加于神经。 初级抑制阳极适于放置在神经的主要阳极纵向位置附近，并向神经施加初级阳极电流。 辅助抑制阳极适于放置在神经的次级阳极纵向位置附近，并将次要阳极电流施加到神经，次级阳极纵向位置比阴极纵向更靠近初级阳极纵向位置 现场。

公开(公告)号：US08060197B2

公开(公告)日：2011-11-15

申请号：US11724899

申请日：2007-03-16

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/37

CPC分类号： A61B5/0215 ,  A61B5/0464 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/3621

摘要： Apparatus is provided, which includes an electrode device, configured to be coupled to an atrial site of a subject containing parasympathetic nervous tissue, and a control unit. The control unit is configured to, responsively to a detection of an episode of non-sinus atrial tachycardia, restore normal sinus rhythm (NSR) of the subject, by driving the electrode device to apply a parasympathetic stimulation signal to the atrial site, and configuring the parasympathetic stimulation signal to activate the parasympathetic nervous tissue sufficiently to restore the NSR. Other embodiments are also described.

摘要翻译： 提供了包括电极装置的装置，其被配置为耦合到包含副交感神经组织的受试者的心房部位和控制单元。 控制单元被配置为响应于检测到非窦房性心动过速的发作，通过驱动电极装置将副交感神经刺激信号施加到心房部位来恢复受试者的正常窦性心律（NSR），并且配置 副交感神经刺激信号激活副交感神经组织足以恢复NSR。 还描述了其它实施例。

公开(公告)号：US08005545B2

公开(公告)日：2011-08-23

申请号：US11974951

申请日：2007-10-16

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/04

CPC分类号： A61N1/0556 ,  A61N1/36114

摘要： A method is provided, including identifying that a subject is at risk of suffering from atrial fibrillation (AF). Responsively to the identifying, a risk of an occurrence of an episode of the AF is reduced by applying an electrical current to a site of the subject selected from the group consisting of: a vagus nerve, a sinoatrial (SA) node fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a jugular vein, an azygos vein, an innominate vein, and a subclavian vein, and configuring the current to stimulate autonomic nervous tissue in the site. Other embodiments are also described.

摘要翻译： 提供了一种方法，包括识别受试者处于心房颤动（AF）的风险。 响应于识别，通过向选自以下的组中的受试者的位点施加电流来减少AF的发作的风险：迷走神经，窦房（SA）节点脂肪垫， 肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉，颈静脉，纯合静脉，无名静脉和锁骨下静脉，并配置电流以刺激部位的自主神经组织。 还描述了其它实施例。

公开(公告)号：US07890185B2

公开(公告)日：2011-02-15

申请号：US10722589

申请日：2003-11-25

申请人： Ehud Cohen ,  Yossi Gross ,  Shai Ayal

发明人： Ehud Cohen ,  Yossi Gross ,  Shai Ayal

IPC分类号： A61N1/00

CPC分类号： A61N1/36007 ,  A61N1/36114

摘要： Apparatus for treating a condition of a subject is provided. An electrode device is adapted to be coupled to longitudinal nervous tissue of the subject, and a control unit is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.

摘要翻译： 提供了用于治疗受试者状况的装置。 电极装置适于耦合到受试者的纵向神经组织，并且控制单元适于驱动电极装置向神经组织施加能够诱导在神经组织中传播的动作电位的电流 第一个方向，以处理病情。 控制单元还适于抑制动作电位在与第一方向相反的第二方向上在神经组织中传播。

公开(公告)号：US07882325B2

公开(公告)日：2011-02-01

申请号：US11963295

申请日：2007-12-21

申请人： Zeev Sperber ,  Robert Valentine ,  Ehud Cohen ,  Doron Orenstien ,  Benny Eitan

发明人： Zeev Sperber ,  Robert Valentine ,  Ehud Cohen ,  Doron Orenstien ,  Benny Eitan

IPC分类号： G06F12/04

CPC分类号： G06F9/30043 ,  G06F9/30036 ,  G06F9/30145 ,  G06F9/3806 ,  G06F9/3808 ,  G06F9/3834 ,  G06F9/3855 ,  G06F9/3857 ,  G06F9/3875 ,  G06F9/3887

摘要： A single micro-instruction to perform either an N-bit or a 2N-bit load is provided. A microprocessor having an N-bit load port performs either an N-bit load or a 2N-bit load in a single cycle with the same micro-instruction being used for both the N-bit and the 2N-bit load.

摘要翻译： 提供执行N位或2N位负载的单个微指令。 具有N位负载端口的微处理器在单个周期中执行N位负载或2N位负载，同时使用相同的微指令用于N位和2N位负载。

公开(公告)号：US20100169581A1

公开(公告)日：2010-07-01

申请号：US12346543

申请日：2008-12-30

申请人： Gad Sheaffer ,  Shlomo Raikin ,  Vadim Bassin ,  Raanan Sade ,  Ehud Cohen ,  Oleg Margulis

发明人： Gad Sheaffer ,  Shlomo Raikin ,  Vadim Bassin ,  Raanan Sade ,  Ehud Cohen ,  Oleg Margulis

IPC分类号： G06F12/08 ,  G06F12/00

CPC分类号： G06F9/3834 ,  G06F9/467 ,  G06F12/0831 ,  G06F12/084

摘要： A method and apparatus for extending cache coherency to hold buffered data to support transactional execution is herein described. A transactional store operation referencing an address associated with a data item is performed in a buffered manner. Here, the coherency state associated with cache lines to hold the data item are transitioned to a buffered state. In response to local requests for the buffered data item, the data item is provided to ensure internal transactional sequential ordering. However, in response to external access requests, a miss response is provided to ensure the transactionally updated data item is not made globally visible until commit. Upon commit, the buffered lines are transitioned to a modified state to make the data item globally visible.

摘要翻译： 这里描述了用于扩展高速缓存一致性以保存缓冲数据以支持事务执行的方法和装置。 以缓冲的方式执行引用与数据项相关联的地址的事务存储操作。 这里，与保存数据项的高速缓存行相关联的一致性状态被转换到缓冲状态。 响应缓冲数据项的本地请求，提供数据项以确保内部事务顺序排序。 然而，响应于外部访问请求，提供了错误响应以确保事务更新的数据项在提交之前不会被全局可见。 一旦提交，缓存的行将转换到修改状态，使数据项全局可见。

公开(公告)号：US07561922B2

公开(公告)日：2009-07-14

申请号：US11022011

申请日：2004-12-22

申请人： Ehud Cohen ,  Tamir Ben David ,  Shai Ayal ,  Omry Ben Ezra

发明人： Ehud Cohen ,  Tamir Ben David ,  Shai Ayal ,  Omry Ben Ezra

IPC分类号： A61N1/05

CPC分类号： A61N1/0556

摘要： Apparatus is provided for applying current to a nerve, including a housing that is adapted to be placed in a vicinity of the nerve. First, second, and third electrodes are fixed to the housing at first, second, and third longitudinal sites of the housing, respectively. The first, second, and third electrodes do not come in direct physical contact with the nerve. The second site is between the first and third sites. The second electrode has an electrode surface axial length. The apparatus also includes first and second internal insulating elements, which are fixed to the housing between the first and second longitudinal sites, and between the second and third longitudinal sites, respectively. The first and second internal insulating elements are shaped so as to define, upon placement of the housing, a nerve axial distance between the first and second internal insulating elements that is less than the electrode surface axial length.

摘要翻译： 提供了用于向神经施加电流的装置，包括适于放置在神经附近的壳体。 第一，第二和第三电极分别在壳体的第一，第二和第三纵向位置处固定到壳体。 第一，第二和第三电极不会与神经直接物理接触。 第二个站点在第一个和第三个站点之间。 第二电极具有电极表面的轴向长度。 该装置还包括第一和第二内部绝缘元件，其分别在第一和第二纵向位置之间以及第二和第三纵向位置之间固定到壳体。 第一和第二内部绝缘元件被成形为在放置壳体时限定第一和第二内部绝缘元件之间的小于电极表面轴向长度的神经轴向距离。

公开(公告)号：US20090070236A1

公开(公告)日：2009-03-12

申请号：US12270035

申请日：2008-11-13

申请人： Ehud Cohen ,  Albert J. Angel ,  Tamar Katzav ,  Abraham Stern

发明人： Ehud Cohen ,  Albert J. Angel ,  Tamar Katzav ,  Abraham Stern

IPC分类号： G06Q30/00 ,  G06Q40/00 ,  G06Q90/00 ,  G06F17/30

CPC分类号： G06Q50/02 ,  G01N21/87 ,  G06Q30/00 ,  G06Q30/0601 ,  G06Q40/00 ,  G06Q40/04

摘要： The transparent diamond and precious stone trading platform and method has funding and delivery transparency during the buy-order, funding, and tracking pickup, independent comparative inspection, and final delivery of each stone. The database of stones includes, for each stone, stone-weight, stone characteristics, price, and a grading lab certificate. The certificate uniquely identifies each stone and is electronically accessible by sellers, buyers, couriers, and authentication services. A buy command is communicated to seller and buyer. The transfer funds is electronically noted and communicated. The pickup by courier, interim delivery, inspection comparing the stone to the certificate, and subsequent delivery to buyer and release of funds is communicated to traders by emails, text messages, automated voice messages or IVR. Buyer and seller profiles establish communications channels and organizational managers are also permitted access and given communications. If time or place parameters are exceeded, increasing levels of alarm electronic communications are implemented.

摘要翻译： 透明钻石和宝石交易平台和方法在购买订单，资金和跟踪拾取，独立比较检查和每个石材的最终交付期间都有资金和交货透明度。 石头数据库包括石材，石材，石材特征，价格和分级实验室证书。 证书唯一地标识每个石头，并且由卖方，买方，快递员和认证服务可电子访问。 买卖指令传达给卖方和买方。 转账资金以电子方式注明和传达。 通过邮件，短信，自动语音信息或IVR将交易者通过快递，临时交货，比较石头和证书，以及随后交付给买方和发行资金的交货通知给交易者。 买家和卖家简介建立沟通渠道，组织经理也被允许访问和通信。 如果超过时间或地点参数，则会实施增加警报电子通信的级别。

公开(公告)号：US20080275514A1

公开(公告)日：2008-11-06

申请号：US11975169

申请日：2007-10-17

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.

摘要翻译： 提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。 该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎， 包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合 结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

公开(公告)号：US20080161894A1

公开(公告)日：2008-07-03

申请号：US11975646

申请日：2007-10-19

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61B1/00 ,  A61B5/04

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3627

摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.

摘要翻译： 提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏 脉冲和抗心律变能。 所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。 第一和第二控制单元不在一般控制之下。 控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。 还描述了其它实施例。