公开(公告)号：US20160081960A1

公开(公告)日：2016-03-24

申请号：US14888764

申请日：2014-05-07

Applicant: MCMASTER UNIVERSITY

Inventor： Gerry Wright ,  Wenliang Wang ,  Andrew King

IPC: A61K31/198 ,  A61K31/407 ,  A61K45/06

CPC classification number: A61K31/198 ,  A61K31/407 ,  A61K31/4196 ,  A61K45/06 ,  Y02A50/473

Abstract: The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of one or more β-lactam antibiotics and one or more compounds of Formula I: (I) for treatment of a metallo-B-lactamase-expressing bacterial infection or a disease, disorder or condition arising from a metallo-B-lactamase-expressing bacterial infection.

Abstract translation: 本申请涉及细菌感染的组合治疗。 例如，本申请涉及使用一种或多种β-内酰胺抗生素和一种或多种式I化合物：（I）用于治疗表达金属-β-内酰胺酶的细菌感染或疾病，病症或病症 由表达金属B-内酰胺酶的细菌感染引起。

公开(公告)号：US20150368367A1

公开(公告)日：2015-12-24

申请号：US14745929

申请日：2015-06-22

Applicant: McMaster University

Inventor： Zhen Hu ,  Emily Cranston

IPC: C08B15/00 ,  C08B15/06 ,  C08B15/05

CPC classification number: C08B15/00 ,  C08B15/08 ,  C08J7/12 ,  C08K9/04 ,  C08K9/08

Abstract: Hydrophobic CNCs were successfully prepared by grafting amine- and thiol terminated hydrocarbons to CNCs that have been previously coated with plant polyphenols. Hydrocarbons of various chain lengths can be used to tune the hydrophobicity of the modified CNCs. After the surface modification process, CNCs can be easily redispersed in nonpolar solvents highlighting the potential of the hydrophobic CNCs in, for example, CNC reinforced nanocomposites and non-aqueous formulations.

Abstract translation: 通过将胺和硫醇封端的烃接枝到预先用植物多酚涂覆的CNCs来成功制备疏水性CNCs。 可以使用各种链长的烃来调节改性的CNCs的疏水性。 在表面改性过程之后，CNCs可以容易地再分散在非极性溶剂中，突出了例如CNC增强纳米复合材料和非水性配方中疏水性CNCs的潜力。

公开(公告)号：US20150207439A1

公开(公告)日：2015-07-23

申请号：US14599838

申请日：2015-01-19

Applicant: McMaster University

Inventor： Jin Ye ,  Ali Emadi

IPC: H02P6/10 ,  H02P6/00

CPC classification number: H02P6/10 ,  B62D5/046 ,  H02P6/14 ,  H02P25/098

Abstract: A method for controlling a switched reluctance motor, the method comprising: receiving a reference torque Te ref; receiving an indication of a present rotor position θ for the switched reluctance motor; determining at least one of: a reference current ie—ref(k−1) for a (k−1)th phase, a reference current ie—ref(k) for a (k)th phase, and a reference current ie—ref(k+1) for a (k+1)th phase; and outputting the determined at least one reference current to a current controller operatively coupled to the switched reluctance motor, wherein the determined at least one reference current is based on an objective function comprising the squares of phase current and derivatives of current reference.

Abstract translation: 一种用于控制开关磁阻电动机的方法，所述方法包括：接收参考转矩Te ref; 接收当前转子位置的指示; 用于开关磁阻电动机; 确定第（k-1）相的参考电流ie-ref（k-1），第（k）相的参考电流ie-ref（k）和参考电流ie- ref（k + 1）for（k + 1）phase; 并将所确定的至少一个参考电流输出到可操作地耦合到开关磁阻电机的电流控制器，其中所确定的至少一个参考电流基于包括相电流的平方和电流参考的导数的目标函数。

公开(公告)号：US20150038450A1

公开(公告)日：2015-02-05

申请号：US14461783

申请日：2014-08-18

Applicant: McMaster University

Inventor： Mickie Bhatia ,  Eleftherios Sachlos

IPC: A61K31/7068 ,  A61K31/5415

CPC classification number: A61K31/7068 ,  A61K31/5415 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K2300/00

Abstract: Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

Abstract translation: 描述了用于治疗癌症的方法和组合物，其包括多巴胺受体（DR）拮抗剂如硫利达嗪和化学治疗剂。 任选地，化学治疗剂是DNA合成抑制剂，例如阿糖胞苷或微管抑制剂如紫杉醇或多西他赛。 所述方法和组合物可用于治疗癌症如急性骨髓性白血病。

公开(公告)号：US20140010652A1

公开(公告)日：2014-01-09

申请号：US13937310

申请日：2013-07-09

Applicant: McMaster University

Inventor： Piranavan Suntharalingam ,  Ali Emadi

IPC: B64D35/08

CPC classification number: B64D35/08 ,  B64D27/02 ,  B64D2027/026 ,  Y02T50/44 ,  Y02T50/64

Abstract: A hybrid powertrain for an aircraft may include a drive shaft, the drive shaft, an internal combustion engine to selectably drive the drive shaft, a propeller coupled to the drive shaft and an electric motor having a stator and a rotor and operable to selectably drive the drive shaft. The drive shaft may extend through the electric motor. The rotor may be coupled to the drive shaft to rotate with the drive shaft and the rotor is a flywheel for the internal combustion engine.

Abstract translation: 用于飞行器的混合动力系统可以包括驱动轴，驱动轴，可选择地驱动驱动轴的内燃机，联接到驱动轴的螺旋桨和具有定子和转子的电动机，并且可操作地驱动 传动轴。 驱动轴可以延伸穿过电动机。 转子可以联接到驱动轴以与驱动轴一起旋转，并且转子是用于内燃机的飞轮。

公开(公告)号：US20130252773A1

公开(公告)日：2013-09-26

申请号：US13850757

申请日：2013-03-26

Applicant: MCMASTER UNIVERSITY

Inventor： Piranavan Suntharalingam ,  Ali Emadi

IPC: B60K6/387

CPC classification number: B60K6/387 ,  B60K6/445 ,  B60K6/52 ,  B60K2006/266 ,  B60K2006/4841 ,  F16H3/727 ,  F16H3/728 ,  Y02T10/6239 ,  Y02T10/6265 ,  Y10S903/902

Abstract: A powertrain system for a vehicle is provided. The powertrain system includes an internal combustion engine, a first gearset connected to the internal combustion engine, a first electric machine connected to the first gearset, a drivetrain gear for connection to a drivetrain of the vehicle, a second gearset connecting the first gearset to the drivetrain gear, a second electric machine, and at least one dynamic clutch selectively coupling the second electric machine to the first electric machine, the first gearset, and the second gearset. In a first mode of operation, the at least one dynamic clutch couples the second electric machine and the first electric machine. In a second mode of operation, the at least one dynamic clutch couples the second electric machine and the first gearset. In a third mode of operation, the at least one dynamic clutch couples the second electric machine and the second gearset.

Abstract translation: 提供了一种用于车辆的动力系统。 动力系统包括内燃机，连接到内燃机的第一齿轮组，连接到第一齿轮组的第一电机，用于连接到车辆的传动系的传动系齿轮;将第一齿轮组连接到第二齿轮组的第二齿轮组， 传动系齿轮，第二电机和至少一个选择性地将第二电机耦合到第一电机，第一齿轮组和第二齿轮组的动态离合器。 在第一操作模式中，至少一个动态离合器将第二电机和第一电机耦合。 在第二操作模式中，所述至少一个动态离合器将所述第二电机和所述第一齿轮组连接。 在第三操作模式中，至少一个动力离合器将第二电机和第二齿轮组连接。

公开(公告)号：US20250132538A1

公开(公告)日：2025-04-24

申请号：US18490498

申请日：2023-10-19

Applicant: HUAWEI TECHNOLOGIES CANADA CO., LTD. ,  MCMASTER UNIVERSITY

Inventor： Xun LI ,  Chuanning NIU ,  Manpo YANG ,  Tan Huy HO

IPC: H01S5/12 ,  H01S5/183 ,  H01S5/30

Abstract: A distributed feedback (DFB) semiconductor laser assembly is disclosed. The DFB laser assembly includes a substrate extending along a longitudinal direction, a first electrode layer disposed on a first side surface thereof, an active region layer disposed on a second side surface thereof opposite the first side surface, and a spacer layer disposed on the active region layer. A ridge extends away from the active region layer and along the longitudinal direction. The DFB laser assembly also includes a grating layer integrated between the active region layer and the ridge, the grating layer including a plurality of sampled gratings along the longitudinal direction, and a second electrode layer electrically coupled to the first electrode layer, the second electrode layer comprising independent electrode sections disposed on the top ridge surface and each ridge side surface.

公开(公告)号：US20250099058A1

公开(公告)日：2025-03-27

申请号：US18730936

申请日：2023-01-20

Applicant: McMaster University

Inventor： Zahra Keshavarz Motamed ,  Mohamed Abdelkhalek

IPC: A61B6/50 ,  A61B6/00 ,  A61B6/03 ,  G06T5/20 ,  G06T5/70 ,  G06T7/00 ,  G06T7/11 ,  G06T7/62 ,  G06T7/66 ,  G16H30/40

Abstract: Described is a method for assessing aortic valve calcification using contrast-enhanced CT. The method comprises: receiving CT images of the aortic valve; pre-processing received images to have a field of view focused on an aortic root corresponding to the aortic valve; implementing a fast-marching method for the pre-processed images to segment the aortic valve from surrounding tissue to generate an aortic root model; determining multiple principal axes and multiple landmark points based on the pre-processed images and the aortic root model to define a local coordinate system relative to leaflets of the aortic valve; generating a calcification model based on the pre-processed images and aortic root model by iteratively changing an initial estimate of calcific HU threshold until a minimum false positive rate FPR criterion is reached; and generating an indicator quantifying calcification of the aortic valve based on the calcification model, the principal axes and the landmark points.

公开(公告)号：US20250043249A1

公开(公告)日：2025-02-06

申请号：US18924564

申请日：2024-10-23

Applicant: McMaster University

Inventor： Ponnambalam Ravi Selvaganapathy ,  Maedeh Khodamoradi

IPC: C12N5/071

Abstract: This disclosure relates to methods of fabricating self-assembled 3D cell sheets. In one embodiment, the cell sheets are formed by seeding cells to a monolayer density of at least 65% with a culture medium on to a substantially flat substrate having low surface energy and incubating cells on the substrate under time and temperature conditions to form a cell sheet.

公开(公告)号：US20250041235A1

公开(公告)日：2025-02-06

申请号：US18286732

申请日：2022-04-13

Applicant: McMaster University

Inventor： Maikel Rheinstadter ,  Sebastian Himbert ,  Isabella Passos-Gastaldo ,  Hannah Krivic ,  Margaret Fahnestock

IPC: A61K9/50 ,  A61K38/18 ,  A61K39/215 ,  A61K45/06 ,  A61P37/04 ,  A61K39/00

Abstract: Described herein is a functionalized biological membrane comprising an endogenous bilayer and one or more modifying protein molecules embedded therein or attached thereto. Also described herein is a method of preparing a functionalized biological membrane comprising one or more modifying protein molecules embedded therein or attached thereto, and methods of use and uses of said functionalized biological membranes.