公开(公告)号：US20150368367A1

公开(公告)日：2015-12-24

申请号：US14745929

申请日：2015-06-22

Applicant: McMaster University

Inventor： Zhen Hu ,  Emily Cranston

IPC: C08B15/00 ,  C08B15/06 ,  C08B15/05

CPC classification number: C08B15/00 ,  C08B15/08 ,  C08J7/12 ,  C08K9/04 ,  C08K9/08

Abstract: Hydrophobic CNCs were successfully prepared by grafting amine- and thiol terminated hydrocarbons to CNCs that have been previously coated with plant polyphenols. Hydrocarbons of various chain lengths can be used to tune the hydrophobicity of the modified CNCs. After the surface modification process, CNCs can be easily redispersed in nonpolar solvents highlighting the potential of the hydrophobic CNCs in, for example, CNC reinforced nanocomposites and non-aqueous formulations.

Abstract translation: 通过将胺和硫醇封端的烃接枝到预先用植物多酚涂覆的CNCs来成功制备疏水性CNCs。 可以使用各种链长的烃来调节改性的CNCs的疏水性。 在表面改性过程之后，CNCs可以容易地再分散在非极性溶剂中，突出了例如CNC增强纳米复合材料和非水性配方中疏水性CNCs的潜力。

公开(公告)号：US09815910B2

公开(公告)日：2017-11-14

申请号：US14745929

申请日：2015-06-22

Applicant: McMaster University

Inventor： Zhen Hu ,  Emily Cranston

IPC: C08L1/00 ,  C08B15/00 ,  C08B15/08 ,  C08J7/12 ,  C08K9/04

CPC classification number: C08B15/00 ,  C08B15/08 ,  C08J7/12 ,  C08K9/04 ,  C08K9/08

Abstract: Hydrophobic CNCs were successfully prepared by grafting amine- and thiol terminated hydrocarbons to CNCs that have been previously coated with plant polyphenols. Hydrocarbons of various chain lengths can be used to tune the hydrophobicity of the modified CNCs. After the surface modification process, CNCs can be easily redispersed in nonpolar solvents highlighting the potential of the hydrophobic CNCs in, for example, CNC reinforced nanocomposites and non-aqueous formulations.

公开(公告)号：US10752876B2

公开(公告)日：2020-08-25

申请号：US15757033

申请日：2016-09-02

Applicant: MCMASTER UNIVERSITY

Inventor： Michael Thompson ,  Zhou Xing ,  Daniel Adam LeClair ,  Emily Cranston

IPC: C07K16/24 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  A61K38/17 ,  C12N1/04 ,  C12N15/86 ,  C12N7/00 ,  A61K9/00 ,  A61K9/16 ,  A61K39/235 ,  A61K48/00

Abstract: The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of dextran and mannitol in amounts effective to maintain at least 40% of the adenovirus activity after spray drying.

公开(公告)号：US20190062692A1

公开(公告)日：2019-02-28

申请号：US15757033

申请日：2016-09-02

Applicant: MCMASTER UNIVERSITY

Inventor： Michael Thompson ,  Zhou Xing ,  Daniel Adam LeClair ,  Emily Cranston

IPC: C12N1/04 ,  C12N15/86 ,  A61K9/00 ,  A61K39/235 ,  A61K9/16

CPC classification number: C12N1/04 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K39/235 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2710/10351

Abstract: The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of dextran and mannitol in amounts effective to maintain at least 40% of the adenovirus activity after spray drying.