公开(公告)号：USRE40546E1

公开(公告)日：2008-10-21

申请号：US11119495

申请日：1996-05-01

Applicant: Sherri Clarkson ,  Mehar Manku ,  Peter Redden ,  Paul Wakefield ,  Paul Bradley ,  Philip Knowles ,  Andrea Pitt ,  Austin McMordie

Inventor： David Fredrick Horrobin

IPC: C07C57/13

CPC classification number: C07C69/34 ,  C07C69/593 ,  C07C69/708 ,  C07C69/734

Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.

公开(公告)号：US20060040912A1

公开(公告)日：2006-02-23

申请号：US10221218

申请日：2001-03-08

Applicant: Paul Bradley ,  Mehar Manku

Inventor： Paul Bradley ,  Mehar Manku

IPC: C07D487/22 ,  A61K31/555 ,  A61K31/409

CPC classification number: C07D487/22 ,  A61K41/0071

Abstract: A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the other isocyanate or isothiocyanate group being itself derivatised by addition reaction with the hydroxy group of an w-alkylated or acylated poly(alkylene oxide) or to a hydroxy group of a link residue itself carrying a residue of such poly(alkylene oxide).

Abstract translation: 通过与二异氰酸酯，二异硫氰酸酯或异氰酸酯 - 异硫氰酸酯在一个异氰酸酯或异硫氰酸酯基团的加成反应，在一个或多个羟基衍生的四（羟基苯基）二氢卟酚，细菌二氢卟酚或异细菌素，其它异氰酸酯或异硫氰酸酯基团本身由 与w-烷基化或酰化的聚（环氧烷）的羟基或本身携带这种聚（环氧烷）的残基的连接残基的羟基的加成反应。

公开(公告)号：US6015821A

公开(公告)日：2000-01-18

申请号：US952305

申请日：1998-03-03

Applicant: David Frederick Horrobin ,  Mehar Manku ,  Austin McMordie ,  Philip Knowles ,  Peter Redden ,  Andrea Pitt

Inventor： David Frederick Horrobin ,  Mehar Manku ,  Austin McMordie ,  Philip Knowles ,  Peter Redden ,  Andrea Pitt

IPC: A61K31/44 ,  A61P3/06 ,  C07C69/007 ,  C07C69/587 ,  C07C69/76 ,  C07D209/28 ,  C07D213/30 ,  C07D213/66 ,  C07D213/79 ,  C07D213/80 ,  C07D233/94 ,  C07D279/36 ,  C07D321/00 ,  C07D339/04 ,  C07D499/00 ,  C07F9/09 ,  C07F9/655 ,  C07J1/00 ,  C07J5/00

CPC classification number: C07D213/30 ,  C07C69/007 ,  C07C69/587 ,  C07C69/76 ,  C07D209/28 ,  C07D213/66 ,  C07D213/80 ,  C07D233/94 ,  C07D279/36 ,  C07D321/00 ,  C07D339/04 ,  C07D499/00 ,  C07J1/0059 ,  C07J5/0053

Abstract: Compounds, compositions, and methods of use as a pharmaceutical, where the compounds have structure (I), where B is --C(.dbd.O)-- or --CH.sub.2 --O--, C is a direct bond or is a diol residue, a hydroxy-substituted carboxylic acid residue, or a dicarboxylic acid residue, and D is a fatty acid residue or a fatty alcohol residue, where the acid residues or alcohol residues for ester linkages with the corresponding alcohols or acids.

Abstract translation: PCT No.PCT / GB96 / 01054 Sec。 371日期1998年3月3日 102（e）1998年3月3日PCT PCT 1996年5月1日PCT公布。 公开号WO96 / 34858 日期1996年11月7日化合物具有结构（I）的化合物，组合物和作为药物的方法，其中B是-C（= O） - 或-CH 2 -O-，C是直接键或是 二醇残基，羟基取代的羧酸残基或二羧酸残基，D是脂肪酸残基或脂肪醇残基，其中与相应的醇或酸形成酯键的酸残基或醇残基。