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1.再颁专利1,3-propane diol esters and ethers and methods for their use in drug delivery 失效1,3-丙二醇酯和醚及其用于药物递送的方法公开(公告)号：USRE43632E1
公开(公告)日：2012-09-04
申请号：US12230018
申请日：1996-05-01
申请人： David B. Horrobin , Sherri Clarkson, legal representative , Mehar Manku , Philip Knowles , Peter Redden , Andrea Pitt , Paul Bradley , Paul Wakefield , Austin McMordie
发明人： David B. Horrobin , Mehar Manku , Philip Knowles , Peter Redden , Andrea Pitt , Paul Bradley , Paul Wakefield , Austin McMordie
IPC分类号： C07C57/13
CPC分类号： Y02A50/411
摘要： The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
摘要翻译： 本发明涉及下式的化合物：其中R1选自12至30个碳原子的脂肪酸酰基和12-30个碳原子的脂肪醇基团，其中R2选自H， 12至30个碳原子的脂肪酸酰基和12至30个碳原子的脂肪醇基团，与R1相同或不同，以及营养物，药物或其它生物活性化合物的残基，以及这些化合物的用途 递送药物和其他生物活性化合物。
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2.发明授权1,3-propane diol esters and ethers and methods for their use in drug delivery 失效1,3-丙二醇酯和醚及其用于药物递送的方法公开(公告)号：US06555700B1
公开(公告)日：2003-04-29
申请号：US08945667
申请日：1998-01-28
申请人： David Frederick Horrobin , Mehar Manku , Austin McMordie , Philip Knowles , Peter Redden , Andrea Pitt , Paul Bradley , Paul Wakefield
发明人： David Frederick Horrobin , Mehar Manku , Austin McMordie , Philip Knowles , Peter Redden , Andrea Pitt , Paul Bradley , Paul Wakefield
IPC分类号： C07C5713
CPC分类号： C07D213/30 , C07C69/007 , C07C69/587 , C07C69/76 , C07D209/28 , C07D213/66 , C07D233/94 , C07D279/36 , C07D321/00 , C07D339/04 , C07D499/00 , C07F9/091 , C07F9/65522 , C07J1/0059 , C07J5/0053
摘要： The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
摘要翻译： 本发明涉及下式的化合物：其中R1选自12至30个碳原子的脂肪酸酰基和12-30个碳原子的脂肪醇基团，其中R2选自H， 12至30个碳原子的脂肪酸酰基和12至30个碳原子的脂肪醇基团，与R1相同或不同，以及营养物，药物或其它生物活性化合物的残基，以及这些化合物的用途 递送药物和其他生物活性化合物。
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公开(公告)号：US07375215B2
公开(公告)日：2008-05-20
申请号：US10221218
申请日：2001-03-08
申请人： Paul Bradley , Mehar Manku
发明人： Paul Bradley , Mehar Manku
IPC分类号： C07D487/22 , C07D47/00 , C08G18/08 , A01N55/02 , A61K31/409 , A61K31/555
CPC分类号： C07D487/22 , A61K41/0071
摘要： A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the other isocyanate or isothiocyanate group being itself derivatised by addition reaction with the hydroxy group of an w-alkylated or acylated poly(alkylene oxide) or to a hydroxy group of a link residue itself carrying a residue of such poly(alkylene oxide).
摘要翻译： 通过与二异氰酸酯，二异硫氰酸酯或异氰酸酯 - 异硫氰酸酯在一个异氰酸酯或异硫氰酸酯基团的加成反应，在一个或多个羟基衍生的四（羟基苯基）二氢卟酚，细菌二氢卟酚或异细菌素，其它异氰酸酯或异硫氰酸酯基团本身由 与w-烷基化或酰化的聚（环氧烷）的羟基或本身携带这种聚（环氧烷）的残基的连接残基的羟基的加成反应。
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公开(公告)号：US20060040912A1
公开(公告)日：2006-02-23
申请号：US10221218
申请日：2001-03-08
申请人： Paul Bradley , Mehar Manku
发明人： Paul Bradley , Mehar Manku
IPC分类号： C07D487/22 , A61K31/555 , A61K31/409
CPC分类号： C07D487/22 , A61K41/0071
摘要： A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the other isocyanate or isothiocyanate group being itself derivatised by addition reaction with the hydroxy group of an w-alkylated or acylated poly(alkylene oxide) or to a hydroxy group of a link residue itself carrying a residue of such poly(alkylene oxide).
摘要翻译： 通过与二异氰酸酯，二异硫氰酸酯或异氰酸酯 - 异硫氰酸酯在一个异氰酸酯或异硫氰酸酯基团的加成反应，在一个或多个羟基衍生的四（羟基苯基）二氢卟酚，细菌二氢卟酚或异细菌素，其它异氰酸酯或异硫氰酸酯基团本身由 与w-烷基化或酰化的聚（环氧烷）的羟基或本身携带这种聚（环氧烷）的残基的连接残基的羟基的加成反应。
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公开(公告)号：US08618166B2
公开(公告)日：2013-12-31
申请号：US13540319
申请日：2012-07-02
申请人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
发明人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
IPC分类号： A61K31/232
CPC分类号： A61K31/202 , A61K9/48 , A61K31/222 , A61K31/232 , A61K31/40 , A61K31/505 , A61K31/74 , A61K45/06 , A61K47/22 , A61K47/26 , A61K47/34 , A61K2300/00
摘要： The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
摘要翻译： 本公开尤其涉及用二十碳五烯酸乙酯处理混合型血脂异常的方法。
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6.发明授权公开(公告)号：US08557799B2
公开(公告)日：2013-10-15
申请号：US13403699
申请日：2012-02-23
申请人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
发明人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
摘要： In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
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公开(公告)号：US20130101533A1
公开(公告)日：2013-04-25
申请号：US13655892
申请日：2012-10-19
申请人： Mehar Manku , John Climax , David Coughlan
发明人： Mehar Manku , John Climax , David Coughlan
IPC分类号： A61K31/202
CPC分类号： A61K31/202 , A61K8/361 , A61K9/0014 , A61K47/10 , A61Q17/04 , A61Q19/004 , A61K2300/00
摘要： The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, and/or 15-HETrE, used singly or in combination for the prevention and/or treatment of effects associated with UV radiation such as erythema.
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公开(公告)号：US08415335B2
公开(公告)日：2013-04-09
申请号：US13349157
申请日：2012-01-12
申请人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
发明人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
CPC分类号： A61K31/232 , A61K31/202 , A61K45/06 , G06F19/00
摘要： In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
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公开(公告)号：US20130017256A1
公开(公告)日：2013-01-17
申请号：US13623450
申请日：2012-09-20
申请人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
发明人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
IPC分类号： A61K31/232 , A61K9/48 , A61P3/06
CPC分类号： A61K31/232 , A61K31/202 , A61K45/06 , G06F19/00
摘要： In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
摘要翻译： 在各种实施方案中，本发明提供了治疗和/或预防心血管相关疾病，特别是血脂治疗方法的方法，其包括向有需要的受试者施用包含二十碳五烯酸或其衍生物的药物组合物。
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公开(公告)号：US08324195B2
公开(公告)日：2012-12-04
申请号：US13349150
申请日：2012-01-12
申请人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
发明人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
CPC分类号： A61K31/232 , A61K31/202 , A61K45/06 , G06F19/00
摘要： In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
摘要翻译： 在各种实施方案中，本发明提供了治疗和/或预防心血管相关疾病，特别是血脂治疗方法的方法，其包括向有需要的受试者施用包含二十碳五烯酸或其衍生物的药物组合物。
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