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113 条记录 (耗时 0.032 秒)

    Methods of collecting a blood plasma constituent
    71.
    发明授权
    Methods of collecting a blood plasma constituent 失效
    收集血浆成分的方法

    公开(公告)号：US6071423A

    公开(公告)日：2000-06-06

    申请号：US222751

    申请日：1998-12-29

    申请人： Richard I. Brown ,  Sidney Smith ,  David E. Cerny ,  John T. Foley

    发明人： Richard I. Brown ,  Sidney Smith ,  David E. Cerny ,  John T. Foley

    IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  A61M1/38

    CPC分类号： B01D17/0217 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3693 ,  A61M1/3696 ,  B01D21/2405 ,  B01D21/2472 ,  B01D21/262 ,  B01D21/34 ,  B04B13/00 ,  B04B5/0442 ,  A61M1/025 ,  A61M1/30 ,  A61M2202/0439 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D2221/10 ,  B04B2005/045

    摘要： A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis. The platelet rich plasma is separated from the residual red blood cells in a first part. The platelet rich plasma flows into the second part and is separated into platelet poor plasma and platelets. The platelet poor plasma can be drawn off and returned to a donor or collected. The platelet concentrate can then be accumulated in a separate container.

    摘要翻译： 治疗成分与血液分离的系统和方法。 该系统包括双组分离心机和一次性单次使用的流体输送装置。 该组件包括细长的柔性分离室，其具有输入端口，分离的部件输出端口和残余流体输出端口。 输入端口和分离的部件输出端口位于细长分离室的相对端。 离心机包括其中具有选择性地形成的环形槽的容纳室。 分离室定位在环形槽中并以预定的旋转速度旋转。 诸如全血的流体流过分离室并分离成各种治疗成分，例如富含血小板的血浆和残留的浓缩红细胞。 血小板富集血浆可作为分离的治疗成分被排出。 替代的两部分转移组提供了高效血小板凝固。 在第一部分中将富含血小板的血浆与剩余的红细胞分离。 富含血小板的血浆流入第二部分，并分离成血小板不足的血浆和血小板。 可以将血小板质量差的血浆抽出并返回给供体或收集。 然后可以将血小板浓缩物积聚在单独的容器中。

    Systems and methods for collecting diluted mononuclear cells
    72.
    发明授权
    Systems and methods for collecting diluted mononuclear cells 失效
    用于收集稀释的单核细胞的系统和方法

    公开(公告)号：US6027657A

    公开(公告)日：2000-02-22

    申请号：US886732

    申请日：1997-07-01

    申请人： Kyungyoon Min ,  Richard I Brown ,  Robert J Cantu

    发明人： Kyungyoon Min ,  Richard I Brown ,  Robert J Cantu

    IPC分类号： A61K35/14 ,  A61M1/36 ,  A61M1/38 ,  B01D21/26 ,  B04B5/04

    CPC分类号： B01D21/302 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  B01D21/262 ,  B04B5/0442 ,  B01D2221/10 ,  B04B2005/045

    摘要： Systems and methods rotate a chamber, in which whole blood is centrifugally separated into packed red blood cells, a plasma constituent, and an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit. The interface control unit is operative in a first state to enable removal of platelet-poor plasma in a first container for use as a diluting liquid. In a second state, the interface control unit retains mononuclear cells in the chamber, while removing platelet-rich plasma from the chamber, bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character. In a third state, the interface control unit enables the removal of mononuclear cells from the chamber in a path that leads to a second container, where the mononuclear cells are collected. The systems and methods direct platelet-poor plasma from the first container to the second container to dilute the removed mononuclear cells in the second container.

    摘要翻译： 系统和方法旋转室，其中全血离心分离成包装的红细胞，血浆成分以及填充的红细胞和血浆成分之间的界面。 界面携带血小板和单核细胞。 系统和方法包括接口控制单元。 界面控制单元在第一状态下操作以使得能够在用作稀释液体的第一容器中移除贫血小血浆。 在第二状态下，界面控制单元在腔室中保留单核细胞，同时从腔室中除去富含血小板的血浆，绕过血小板收集容器，从而维持其血小板减少的特征。 在第三状态下，界面控制单元能够在通向收集单核细胞的第二容器的路径中从腔室去除单核细胞。 系统和方法将血小板从第一容器直接引导到第二容器，以稀释第二容器中去除的单核细胞。

    Blood collection systems and methods which derive instantaneous blood component yield information during blood processing
    74.
    发明授权
    Blood collection systems and methods which derive instantaneous blood component yield information during blood processing 失效
    在血液处理过程中产生血液成分产生信息的血液采集系统和方法

    公开(公告)号：US5833866A

    公开(公告)日：1998-11-10

    申请号：US807820

    申请日：1997-02-26

    申请人： Richard I. Brown

    发明人： Richard I. Brown

    IPC分类号： A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  B01D17/12 ,  A61M37/00

    CPC分类号： A61M1/385 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3693 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/262 ,  B01D21/30 ,  B04B13/00 ,  B04B5/0442 ,  A61M1/30 ,  B01D2221/10

    摘要： Systems and methods for separating platelets from blood derive the yield of platelets in real time as processing is accomplished. The systems and method determine an incremental blood volume processed during a succession of incremental time periods during the separation step. The systems and methods also estimate a separation efficiency for the separation device during each incremental time period, while also estimating a current count of platelets available from the donor during each incremental time period. The systems and methods multiply the determined incremental blood volume for each incremental time period by the estimated current count of platelets for each incremental time period by the estimated separation efficiency for each incremental time period, to derive an incremental platelet yield for each incremental time period. The systems and methods sum the incremental platelet yields over the succession of incremental time periods to obtain the derived yield of platelets. In this way, the systems and methods take into account the dynamic systemic and physiological changes that occur virtually continuously throughout the blood collection and separation process.

    摘要翻译： 将血小板与血液分离的系统和方法可以在处理完成时实时获得血小板的产量。 系统和方法确定在分离步骤期间的连续增量时间段期间处理的增量血液体积。 系统和方法还估计在每个增量时间段期间分离装置的分离效率，同时还估计在每个增量时间段期间从供体获得的血小板的当前计数。 系统和方法将每个增量时间段的确定的增量血液体积乘以每个增量时间段的估计的血小板的当前计数值与每个增量时间段的估计分离效率相乘，以得出每个增量时间段的增量血小板产量。 系统和方法总结了递增时间段连续增加的血小板产量，以获得血小板的衍生产量。 以这种方式，系统和方法考虑到在血液收集和分离过程中几乎连续发生的动态全身和生理变化。

    Rectifying dialyzer, bioreactor and membrane
    77.
    发明授权
    Rectifying dialyzer, bioreactor and membrane 失效
    整形透析器，生物反应器和膜

    公开(公告)号：US5527467A

    公开(公告)日：1996-06-18

    申请号：US259279

    申请日：1994-06-13

    申请人： Norma J. Ofsthun ,  Lee W. Henderson ,  Richard I. Brown ,  Robin G. Pauley

    发明人： Norma J. Ofsthun ,  Lee W. Henderson ,  Richard I. Brown ,  Robin G. Pauley

    IPC分类号： B01D61/14 ,  B01D61/24 ,  B01D65/08 ,  B01D69/02 ,  B01D69/08 ,  C12M1/12 ,  C12M3/06 ,  B01D61/28

    CPC分类号： B01D65/08 ,  B01D61/147 ,  B01D61/243 ,  B01D69/02 ,  B01D69/08 ,  B01D2321/2083

    摘要： The invention provides dual-skinned membranes useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification, the microporous structure between said skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties.

    摘要翻译： 本发明提供双皮肤膜，其可用作单向或整流膜，其减少透析中溶质分子的反向过滤并改善膜生物反应器中的营养供应和产物回收。 膜是双面聚合材料，优选为中空纤维的形式。 膜在相对侧具有聚合物的表面，对溶质和筛分系数特性具有不同的渗透性。 每侧的皮肤具有在10,000倍放大率下不可见的孔，所述表皮之间的微孔结构包含能够以内在和外表皮之间增加的浓度保持在约5000至200000的分子量范围内的溶质的孔。 通过使用中空纤维膜束作为具有整流性质的透析装置形成改进的透析装置。

    Centrifuge with separable bowl and spool elements providing access to the separation chamber
    78.
    发明授权
    Centrifuge with separable bowl and spool elements providing access to the separation chamber 失效
    用可分离的碗和卷轴元件离心，提供进入分离室的通道

    公开(公告)号：US5525218A

    公开(公告)日：1996-06-11

    申请号：US334197

    申请日：1994-11-04

    申请人： Warren P. Williamson, IV ,  Richard I. Brown

    发明人： Warren P. Williamson, IV ,  Richard I. Brown

    IPC分类号： B04B5/04 ,  B04B7/08

    CPC分类号： B04B5/0442 ,  B04B2005/045

    摘要： A centrifuge provides simplify access to the processing chamber. In one arrangement, the processing chamber separates into a bowl and spool element to receive a disposable processing bag. In another arrangement, the processing chamber pivots between an operating position and an access position to provide improved access. The centrifuge also employs readily accessible holders for releasably retaining tubing that, in use, conveys fluid to and from the chamber. Though greatly accessible, the centrifuge operates without the need of complicated rotating seals and expensive disposable components.

    摘要翻译： 离心机可简化进入处理室的通道。 在一种布置中，处理室分成碗和卷轴元件以接收一次性处理袋。 在另一种布置中，处理室在操作位置和进入位置之间枢转以提供改进的通路。 离心机还采用易于接近的保持器，用于可释放地保持在使用中将流体输送到腔室的管道。 虽然离合器很容易操作，但不需要复杂的旋转密封件和昂贵的一次性部件。

    Centrifugation pheresis system
    79.
    发明授权
    Centrifugation pheresis system 失效
    离心取样系统

    公开(公告)号：US5494578A

    公开(公告)日：1996-02-27

    申请号：US199082

    申请日：1994-02-22

    申请人： Richard I. Brown ,  Sidney Smith ,  David E. Cerny ,  John T. Foley

    发明人： Richard I. Brown ,  Sidney Smith ,  David E. Cerny ,  John T. Foley

    IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  B04B7/00 ,  B04B7/08

    CPC分类号： B01D17/0217 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3693 ,  A61M1/3696 ,  B01D21/2405 ,  B01D21/2472 ,  B01D21/262 ,  B01D21/34 ,  B04B13/00 ,  B04B5/0442 ,  A61M1/025 ,  A61M1/30 ,  A61M2202/0439 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D2221/10 ,  B04B2005/045

    摘要： A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis. The platelet rich plasma is separated from the residual red blood cells in a first part. The platelet rich plasma flows into the second part and is separated into platelet poor plasma and platelets. The platelet poor plasma can be drawn off and returned to a donor or collected. The platelet concentrate can then be accumulated in a separate container.

    摘要翻译： 治疗成分与血液分离的系统和方法。 该系统包括双组分离心机和一次性单次使用的流体输送装置。 该组件包括细长的柔性分离室，其具有输入端口，分离的部件输出端口和残余流体输出端口。 输入端口和分离的部件输出端口位于细长分离室的相对端。 离心机包括其中具有选择性地形成的环形槽的容纳室。 分离室定位在环形槽中并以预定的旋转速度旋转。 诸如全血的流体流过分离室并分离成各种治疗成分，例如富含血小板的血浆和残留的浓缩红细胞。 血小板富集血浆可作为分离的治疗成分被排出。 替代的两部分转移组提供了高效血小板凝固。 在第一部分中将富含血小板的血浆与剩余的红细胞分离。 富含血小板的血浆流入第二部分，并分离成血小板不足的血浆和血小板。 可以将血小板质量差的血浆抽出并返回给供体或收集。 然后可以将血小板浓缩物积聚在单独的容器中。