公开(公告)号：US11730873B2

公开(公告)日：2023-08-22

申请号：US18109547

申请日：2023-02-14

申请人： FENWAL, INC.

发明人： Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  G01N33/48 ,  G16H10/60

CPC分类号： A61M1/3496 ,  A61M1/3607 ,  A61M1/3616 ,  A61M1/3643 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/382 ,  A61M1/385 ,  G01N33/48 ,  G16H10/60 ,  A61M2202/0415 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2230/207

摘要： A method of collecting plasma includes receiving donor parameters at a controller of a plasma collection device electronically from a donor management system. The method includes storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The method includes setting the target volume for raw plasma and controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor. The controller operates the draw and return phases until a volume of raw plasma in the collection container equals the target volume of raw plasma.

公开(公告)号：US20180344921A1

公开(公告)日：2018-12-06

申请号：US15793339

申请日：2017-10-25

申请人： Haemonetics Corporation

发明人： Michael Ragusa

IPC分类号： A61M1/38 ,  A61M1/36

CPC分类号： A61M1/385 ,  A61M1/3496 ,  A61M1/3626 ,  A61M1/3644 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/38 ,  A61M2202/0415 ,  A61M2205/3306 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2230/207

摘要： A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume.

公开(公告)号：US20180078699A1

公开(公告)日：2018-03-22

申请号：US15693799

申请日：2017-09-01

申请人： Fenwal, Inc.

发明人： Jonathan W. Prendergast ,  Lan T. Nguyen ,  Katherine N. Radwanski

IPC分类号： A61M1/36 ,  A61M1/38 ,  B01D63/16

CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3496 ,  A61M1/361 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/385 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0443 ,  B01D63/16

摘要： A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.

公开(公告)号：US20040096814A1

公开(公告)日：2004-05-20

申请号：US10699358

申请日：2003-10-30

申请人： Gambro, Inc.

发明人： Robert Warner Langley ,  Larry Joe Dumont

IPC分类号： A01N001/02 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.

摘要翻译： 用于生产血液成分产品的方法和装置。 在一个实施例中，从全血源收集多个预定类型的血液成分。 使用至少两种在线产量测定技术来确定收获的血液成分的产量。 一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。 预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每个产量来提供确定的产量。 因此，当收集的血液成分被包装时，确定的产量与之相关联，从而提供血液成分产品。

公开(公告)号：US5730883A

公开(公告)日：1998-03-24

申请号：US473316

申请日：1995-06-07

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D17/038 ,  B01D17/12 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

CPC分类号： A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/385 ,  B01D17/0217 ,  B01D21/34 ,  B04B13/00 ,  B04B5/0442 ,  B04B7/08 ,  A61M1/025 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/262 ,  B01D2221/10

摘要： Blood processing systems and methods separate whole blood into red blood cells and a plasma constituent within a rotating centrifugal separation device. The systems and methods convey whole blood into the separation device through an inlet path including a pump operable at a prescribed rate. The systems and methods remove plasma constituent from the separation device through an outlet path including a pump operable at a prescribed rate. The systems and methods derive a value H.sub.b representing an apparent hematocrit of whole blood entering the separation device, where: ##EQU1## and where H.sub.rbc is a value relating to hematocrit of red blood cells in the separation device. The systems and methods generate outputs and control commands based, at least in part, upon H.sub.b.

摘要翻译： 血液处理系统和方法将全血分离成红细胞和旋转离心分离装置内的等离子体成分。 系统和方法通过包括可以规定速率操作的泵的入口路径将全血输送到分离装置中。 系统和方法通过包括以规定速率操作的泵的出口路径从分离装置中除去等离子体成分。 系统和方法得出表示进入分离装置的全血的明显血细胞比容的值Hb，其中：＆lt; IMAGE＆gt;其中Hrbc是与分离装置中的红细胞的血细胞比容有关的值。 系统和方法至少部分地基于Hb生成输出和控制命令。

公开(公告)号：US5496265A

公开(公告)日：1996-03-05

申请号：US140254

申请日：1993-10-21

申请人： Robert W. Langley ,  John J. Keller ,  Steven G. Urdahl

发明人： Robert W. Langley ,  John J. Keller ,  Steven G. Urdahl

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M1/38 ,  G05B13/00 ,  A61M37/00

CPC分类号： A61M1/30 ,  A61M1/02 ,  A61M1/303 ,  A61M1/307 ,  A61M1/3603 ,  A61M1/3609 ,  A61M1/3672 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/385 ,  A61M1/387 ,  A61M1/3643 ,  A61M1/3693 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/12 ,  A61M2205/50

摘要： A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

公开(公告)号：US12083258B2

公开(公告)日：2024-09-10

申请号：US17825918

申请日：2022-05-26

申请人： Fenwal, Inc.

发明人： Amit J. Patel ,  Samantha M. Planas ,  Walter T. Watts ,  Kyungyoon Min ,  Daniel R. Boggs

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  G01N33/48 ,  G16H10/60 ,  G16H40/60

CPC分类号： A61M1/3496 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/3616 ,  A61M1/362262 ,  A61M1/362266 ,  A61M1/3643 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/382 ,  A61M1/385 ,  G01N33/48 ,  G16H10/60 ,  G16H40/60 ,  A61M2202/0415 ,  A61M2205/33 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2230/207

摘要： A system for collecting plasma comprises a separator to separate whole blood from a donor into a plasma product and red blood cells, an anticoagulant line to introduce anticoagulant to the whole blood, a touchscreen, and a controller. The controller is configured to receive donor parameters electronically from a donor management system. The controller is configured to use a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for plasma product and/or raw plasma based on the total donor blood volume. The controller is configured to control the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the red blood cells and to return the red blood cells to the donor.

公开(公告)号：US07270645B2

公开(公告)日：2007-09-18

申请号：US11044887

申请日：2005-01-26

申请人： Robert Warner Langley ,  Larry Joe Dumont

发明人： Robert Warner Langley ,  Larry Joe Dumont

IPC分类号： A61M37/00 ,  A61M1/00 ,  C02F1/00 ,  C02F1/44 ,  B04B3/00

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.

摘要翻译： 用于生产血液成分产品的方法和装置。 在一个实施例中，从全血源收集多个预定类型的血液成分。 使用至少两种在线产量测定技术来确定收获的血液成分的产量。 一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。 预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每个产量来提供确定的产量。 因此，当收集的血液成分被包装时，确定的产量与之相关联，从而提供血液成分产品。

公开(公告)号：US06652476B2

公开(公告)日：2003-11-25

申请号：US09981932

申请日：2001-10-17

申请人： Robert Warner Langley ,  Larry Joe Dumont

发明人： Robert Warner Langley ,  Larry Joe Dumont

IPC分类号： A61M3700

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.

公开(公告)号：US06451203B2

公开(公告)日：2002-09-17

申请号：US09793801

申请日：2001-02-23

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： B01D1712

CPC分类号： A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/385 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  A61M2202/0071 ,  A61M2202/0092

摘要： Blood processing systems and methods separate whole blood into red blood cells and a plasma constituent within a rotating centrifugal separation device. The systems and methods convey whole blood into the separation device through an inlet path including a pump operable at a prescribed rate. The systems and methods remove plasma constituent from the separation device through an outlet path including a pump operable at a prescribed rate. The systems and methods derive a value Hb representing an apparent hematocrit of whole blood entering the separation device, where: H b = H rbc ⁡ ( Q b - Q p ) Q b and where Hrbc is a value relating to hematocrit of red blood cells in the separation device. The systems and methods generate outputs and control commands based, at least in part, upon Hb.

摘要翻译： 血液处理系统和方法将全血分离成红细胞和旋转离心分离装置内的等离子体成分。 系统和方法通过包括可以规定速率操作的泵的入口路径将全血输送到分离装置中。 系统和方法通过包括以规定速率操作的泵的出口路径从分离装置中除去等离子体成分。 系统和方法导出表示进入分离装置的全血的明显血细胞比容的值Hb，其中：Hrbc是与分离装置中红细胞的血细胞比容有关的值。 系统和方法至少部分地基于Hb生成输出和控制命令。