公开(公告)号：US11497713B2

公开(公告)日：2022-11-15

申请号：US16225629

申请日：2018-12-19

Applicant: TargaGenix, Inc. ,  The Research Foundation for The State University of New York ,  Northeastern University

Inventor： James E. Egan ,  Mansoor Amiji ,  Iwao Ojima

IPC: A61K9/107 ,  A61K47/54 ,  A61K47/44 ,  A61K39/395 ,  A61P35/00 ,  A61K31/337 ,  C07K16/28 ,  A61K39/00

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.

公开(公告)号：US20220339248A1

公开(公告)日：2022-10-27

申请号：US17596699

申请日：2020-02-14

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： Moro O. SALIFU ,  Anna BABINSKA

IPC: A61K38/17 ,  A61K47/10 ,  A61K9/00 ,  A61P13/12

Abstract: The present disclosure relates to methods of treating neointimal hyperplasia. The methods include selecting a subject having a blood vessel abnormality, and administering to the subject an amount of a composition, wherein the composition comprises an inhibitor of cell adhesion molecule receptor/Junctional Adhesion Molecule-A (F11R/JAM-A).

公开(公告)号：US20220305025A1

公开(公告)日：2022-09-29

申请号：US17635673

申请日：2020-08-17

Applicant: The Research Foundation for The State University of New York ,  Molecular Targeting Technologies, Inc. ,  Immune Modulatory Therapies LLC

Inventor： Richard B. BANKERT ,  Koon Yan PAK ,  Brian D. GRAY ,  Sathy V. BALU-IYER ,  Raymond KELLEHER ,  Gautam SHENOY ,  Maulasri BHATTA

IPC: A61K31/555 ,  A61K39/395 ,  A61K9/127 ,  C07F3/06 ,  A61P35/00

Abstract: The present disclosure provides compounds that bind phosphatidylserine (PS). Also provided are compositions comprising the compounds and methods of using the compounds and/or compositions. The compounds and compositions may be used to treat an individual having or suspected of having cancer(s), infectious disease(s), chronic inflammation, and/or autoimmune condition(s).

公开(公告)号：US11453914B2

公开(公告)日：2022-09-27

申请号：US16496154

申请日：2018-03-23

Applicant: QUADRANT BIOSCIENCES INC. ,  THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK ,  PENN STATE RESEARCH FOUNDATION

Inventor： Steven D. Hicks ,  Frank A. Middleton ,  Richard Uhlig

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6883

Abstract: Provided are methods for detecting or diagnosing a traumatic brain injury or TBI by detecting concentration levels miRNAs associated with TBI in saliva. Methods for controlled and normalized comparisons of salivary miRNA concentration levels are further provided. Assay kits comprising salivary miRNAs, probes and/or primers for detecting salivary miRNAs are also provided.

公开(公告)号：US11452291B2

公开(公告)日：2022-09-27

申请号：US15931561

申请日：2020-05-13

Applicant: The Research Foundation for The State University of New York

Inventor： David G. Davies

IPC: A01N37/06 ,  A61Q11/00 ,  A01N37/02 ,  A61K8/36 ,  A01N37/18 ,  A61K8/49 ,  G02B1/04

Abstract: One aspect of the present invention is directed to a composition. The composition includes a dispersion inducer comprising: H3C—(CH2)n—CHmCHmR, where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm. The present invention is also directed to methods of using this compound.

公开(公告)号：US20220298103A1

公开(公告)日：2022-09-22

申请号：US17724969

申请日：2022-04-20

Applicant: The Research Foundation for The State University of New York

Inventor： Maurizio Del Poeta ,  Visesato Mor

IPC: C07C251/86 ,  A61K45/06 ,  A61K31/16 ,  A61K31/7072 ,  A61K38/12 ,  A61K31/7048 ,  A61K31/4196 ,  A01N37/28 ,  A61K31/166

Abstract: The present invention provides a compound having the structure:

公开(公告)号：US11426818B2

公开(公告)日：2022-08-30

申请号：US16537361

申请日：2019-08-09

Applicant: The Research Foundation for the State University of new York

Inventor： Scott N. Schiffres ,  Arad Azizi

IPC: B33Y10/00 ,  B23K26/342 ,  B33Y70/00 ,  H01L21/283 ,  H01L23/367 ,  H01L23/373 ,  B33Y80/00 ,  F28F21/02 ,  B32B7/12 ,  F28D15/00 ,  B32B15/01 ,  F28F21/00 ,  F28F21/04 ,  F28F21/08

Abstract: A technique to additively print onto a dissimilar material, especially ceramics and glasses (e.g., semiconductors, graphite, diamond, other metals) is disclosed herein. The technique enables manufacture of heat removal devices and other deposited structures, especially on heat sensitive substrates. It also enables novel composites through additive manufacturing. The process enables rapid bonding, orders-of-magnitude faster than conventional techniques.

公开(公告)号：US20220251566A1

公开(公告)日：2022-08-11

申请号：US17622355

申请日：2020-06-25

Applicant: The Research Foundation for The State University of New York

Inventor： Sergey V. DORONIN ,  Irina A. POTAPOVA ,  Ira S. COHEN

IPC: C12N15/113 ,  C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  A61K35/28

Abstract: The present disclosure is directed to genetically modified carrier/donor cells that are engineered to be resistant to its oligonucleotide payload, and methods of delivering an oligonucleotide into a target cell. The disclosure is also directed to methods of treating cancer using the engineered carrier cells of the disclosure. An aspect of this disclosure is directed to engineering carrier cells to be resistant to the detrimental effects of an oligonucleotide.

公开(公告)号：US20220162254A1

公开(公告)日：2022-05-26

申请号：US17542090

申请日：2021-12-03

Applicant: The Research Foundation For The State University Of New York

Inventor： William G. Kerr ,  John D. Chisholm

IPC: C07J1/00 ,  C07J41/00

Abstract: The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

公开(公告)号：US20220158819A1

公开(公告)日：2022-05-19

申请号：US17438662

申请日：2020-03-13

Applicant: The Research Foundation for The State University of New York

Inventor： Emre SALMAN ,  Milutin STANACEVIC ,  Yasha KARIMI ,  Tutu WAN ,  Yuanfei HUANG

IPC: H04L9/06 ,  H04L9/08

Abstract: A processing unit and a method of operating a processing unit. In an embodiment, the processing unit comprises a SIMON block cipher for transforming plaintext data into encrypted data. A key expansion module generates and outputs one or more encryption keys; and the key expansion module includes a first series of adiabatic registers for holding key generation data values, and for using adiabatic switching to transmit the key generation data values through the first series of adiabatic registers. A round function module receives the plaintext data and the one or more encryption keys, encrypts the plaintext data to generate the encrypted data, and outputs the encrypted data; and the round function module includes a second series of adiabatic registers for holding encryption data, and for using adiabatic switching to transmit the encryption data through the second series of adiabatic registers.