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公开(公告)号：US20180235592A1
公开(公告)日：2018-08-23
申请号：US15749981
申请日：2016-08-03
发明人： Rena Kass , Kristine Widders , Barry M. Fell , Randy Haluck , Peter Dillon
IPC分类号： A61B17/02
CPC分类号： A61B17/0206 , A61B17/0218 , A61B17/0293 , A61B17/3423 , A61B90/30 , A61B90/92 , A61B90/94 , A61B2017/00438 , A61B2017/00477 , A61B2017/00526 , A61B2017/00561 , A61B2017/00796 , A61B2017/00951 , A61B2090/0807
摘要： The device can include a first member connected to a second member via junctions. The members can be statically or pivotally connected at the junctions via arms extending from cross-beams of the members. The junctions can be configured to provide a biasing force. Methods of using the device may include collapsing the device and inserting it through an incision, allowing the biasing force to cause continuous traction and counter-traction adjacent to a leading dissection edge so that retraction of the skin from the tissue can be facilitated during a surgical procedure.
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公开(公告)号：US20240307331A1
公开(公告)日：2024-09-19
申请号：US18173743
申请日：2021-08-23
IPC分类号： A61K31/167 , A61K38/48 , A61P7/04 , A61P9/10
CPC分类号： A61K31/167 , A61K38/482 , A61P7/04 , A61P9/10 , C12Y304/21068
摘要： Hemorrhage and vascular instability can be induced by thrombolytic and anti-coagulant therapies. Presented herein, in certain aspects, are methods for the treatment and/or prevention of hemorrhage and vascular instability that comprise administering a compound disclosed herein to a subject in need thereof.
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3.发明公开公开(公告)号：US20240276648A1
公开(公告)日：2024-08-15
申请号：US18561934
申请日：2022-03-30
发明人： Ning Yi , Yuyan Gao , Antonino Lo Verso, Jr. , Jia Zhu , Daniel Erdely , Robert Lavelle , Huanyu Cheng
CPC分类号： H05K3/143 , A61B5/28 , A61B5/296 , H05K1/092 , H05K3/146 , H05K2203/0156 , H05K2203/0557 , H05K2203/083 , H05K2203/1131 , H05K2203/1173
摘要： The invention includes methods of forming electronic circuitry on a target surface using intense pulsed light-induced mass transfer (IPLMT) of metal nanoparticles (NPs) by applying a pliable mask to a target surface, coating a carrier film with metal NPs, mounting the carrier film to the target surface and over the pliable mask so that the pliable mask is sandwiched between the target surface and the metal NPs. and exposing the metal NPs to light energy to cause atoms of the metal NPs to evaporate and transport through openings of the pliable mask and condense on the target surface, producing a conductive pattern of condensed metal on the target surface. Certain implementations may utilize a kirigami-patterned pliable mask to enhance conformity to a freeform 3D target surface. In certain implementations, zinc (Zn) may be formed by IPLMT of Zn NPs to the target surface.
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公开(公告)号：US20240272077A1
公开(公告)日：2024-08-15
申请号：US18629280
申请日：2024-04-08
CPC分类号： G01N21/6452 , B29D11/00298 , G01N2201/0446
摘要： The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.
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公开(公告)号：US20240270964A1
公开(公告)日：2024-08-15
申请号：US18490614
申请日：2023-10-19
IPC分类号： C08L83/04 , B29C64/124 , B29K83/00 , B33Y10/00 , B33Y70/00
CPC分类号： C08L83/04 , B29C64/124 , B33Y10/00 , B33Y70/00 , B29K2083/00 , C08L2203/30 , C08L2205/025
摘要： Thermosetting formulations useful for forming bulk structures such as in additive manufacturing can include (a) a compound including reactive functional groups, (b) a curing agent having functional groups reactive with the reactive functional groups of the compound, and (c) a photothermally active material. Such formulations can be cured by applying actinic radiation to the formulation.
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公开(公告)号：US12011191B2
公开(公告)日：2024-06-18
申请号：US17148797
申请日：2021-01-14
IPC分类号： A61B17/34 , A61B5/00 , A61B5/06 , A61B5/107 , A61B8/08 , A61B8/12 , A61B34/20 , A61B34/30 , A61B90/10 , A61B90/11 , A61B17/00 , A61B34/10 , A61B90/00
CPC分类号： A61B17/3403 , A61B5/065 , A61B5/1076 , A61B5/6852 , A61B8/0808 , A61B8/12 , A61B34/20 , A61B34/30 , A61B90/10 , A61B90/11 , A61B2017/00106 , A61B2017/00398 , A61B2017/00924 , A61B2017/3407 , A61B2017/3413 , A61B2034/107 , A61B2034/2059 , A61B2034/2063 , A61B2090/0811 , A61B2090/103 , A61B2090/364 , A61B2090/367 , A61B2090/378 , A61B2090/3925
摘要： The present invention provides fixation devices, locking assemblies, and methods for using the same. The fixation devices of the invention are capable of accurate insertion of medical devices by providing detection means of a patient's internal anatomy and localizing a desired target. The devices are capable of locking into position to maintain accuracy.
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公开(公告)号：US20240102372A1
公开(公告)日：2024-03-28
申请号：US18363003
申请日：2023-08-01
发明人： Arash Dahi Taleghani
IPC分类号： E21B43/267 , C09K8/80
CPC分类号： E21B43/267 , C09K8/80
摘要： Tuning fracture hydraulic conductivity can be provided so that high hydraulic conductivity in high temperature zones and low hydraulic conductivity in low temperature zones can be defined in enhanced geothermal systems (EGS). Uniform thermal gradient along flow paths can be provided or defined to help provide such conductivity zones. Experimentation performed to evaluate embodiments showed that embodiments could prevent appearance of dominant flow paths between the wells and maintain high heat extraction rates. Embodiments can greatly increase cumulative heat extraction. Embodiments can also be provided for application solely to the injection wells. Other embodiments can position tuning agents between the wells and still help provide control of the fluid flow in the reservoir and enhance heat extraction.
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8.发明授权公开(公告)号：US11940325B2
公开(公告)日：2024-03-26
申请号：US17870051
申请日：2022-07-21
IPC分类号： G01J3/02 , B22F10/20 , B22F10/25 , B22F10/28 , B22F12/44 , B22F12/45 , B22F12/90 , B33Y50/02 , G01J3/36 , G01J3/443 , B22F10/30 , B22F10/366 , B22F10/38 , B33Y10/00 , G01J3/12
CPC分类号： G01J3/36 , B22F10/20 , B22F10/25 , B22F10/28 , B22F12/44 , B22F12/45 , B22F12/90 , B33Y50/02 , G01J3/0208 , G01J3/443 , B22F10/30 , B22F10/366 , B22F10/38 , B33Y10/00 , G01J2003/1213
摘要： Embodiments of the systems can be configured to receive electromagnetic emissions of a substrate (e.g., a build material of a part being made via additive manufacturing) by a detector (e.g., a multi-spectral sensor) and generate a ratio of the electromagnetic emissions to perform spectral analysis with a reduced dependence on location and orientation of a surface of the substrate relative to the multi-spectral sensor. The additive manufacturing process can involve use of a laser to generate a laser beam for fusion of the build material into the part. The system can be configured to set the multi-spectral sensor off-axis with respect to the laser (e.g., an optical path of the multi-spectral sensor is at an angle that is different than the angle of incidence of the laser beam). This can allow the multi-spectral sensor to collect spectral data simultaneously as the laser is used to build the part.
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公开(公告)号：US11938476B2
公开(公告)日：2024-03-26
申请号：US17749720
申请日：2022-05-20
发明人： Pak Kin Wong , Tak-Sing Wong , Jing Wang , Hui Li , Yi Lu , Ying Wan
IPC分类号： B01L3/00
CPC分类号： B01L3/5025 , B01L3/50273 , B01L2200/00 , B01L2300/0816 , B01L2300/161 , B01L2300/165 , B01L2400/0406 , B01L2400/0481
摘要： A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.
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10.发明公开公开(公告)号：US20240091300A1
公开(公告)日：2024-03-21
申请号：US18506582
申请日：2023-11-10
发明人： Gong CHEN , Gang-Yi WU , Lei ZHANG , Jiu-Chao YIN , Hana YEH , Ning-Xin MA , Grace LEE
IPC分类号： A61K38/05 , A61K31/00 , A61K31/4439 , A61K31/506 , A61K31/519 , C12N5/0793
CPC分类号： A61K38/05 , A61K31/00 , A61K31/4439 , A61K31/506 , A61K31/519 , C12N5/0619 , C12N2501/15 , C12N2501/155 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/08
摘要： Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
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