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公开(公告)号：US20220409651A1
公开(公告)日：2022-12-29
申请号：US17777001
申请日：2020-11-16
Inventor： Abhiram MADDI , Stephen J. FREE
Abstract: Provided are compounds, compositions, and methods for treatment of fungal infections. The compositions comprise the mannose disaccharide analog (2R,3S,4S,5S,6R)-2-((((3S,4R,5R)-4,5-dihydroxypiperidin-3-yl)methyl)thio)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. Methods are also provided for the treatment of fungal infections comprising contacting the infected site with a therapeutically effective concentration of the present compound or compositions.
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公开(公告)号：US11532806B2
公开(公告)日：2022-12-20
申请号：US17006682
申请日：2020-08-28
Inventor： Kenneth Takeuchi , Esther Takeuchi , Amy Marschilok
IPC: H01M4/00 , H01M4/04 , H01M4/50 , H01M4/52 , H01M10/054 , C01G31/00 , C01G45/12 , H01M4/48 , H01M4/58 , H01M10/052 , C01G49/00 , H01M10/0525 , H01M4/02
Abstract: Preparation, characterization, and an electrochemical study of Mg0.1V2O5 prepared by a novel sol-gel method with no high-temperature post-processing are disclosed. Cyclic voltammetry showed the material to be quasi-reversible, with improved kinetics in an acetonitrile-, relative to a carbonate-, based electrolyte. Galvanostatic test data under a C/10 discharge showed a delivered capacity >250 mAh/g over several cycles. Based on these results, a magnesium anode battery, as disclosed, would yield an average operating voltage ˜3.2 Volts with an energy density ˜800 mWh/g for the cathode material, making the newly synthesized material a viable cathode material for secondary magnesium batteries.
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公开(公告)号：US20220391735A1
公开(公告)日：2022-12-08
申请号：US17884768
申请日：2022-08-10
Inventor： Lisa Sundahl Platt
Abstract: The present disclosure presents systems and methods for assessing hospital acquired infection reduction strategies. One such method comprises analyzing, by a computing device, a risk of hospital acquired infections, using supervised learning to generate fuzzy set membership rules; assessing resilience based on observed hospital acquired infection risk moderation performance level across a continuum of fuzzy membership sets; and inferring, by the computing device, a performance of a hospital in hospital acquired infection risk factor prevention employing the fuzzy membership set rules. Other systems and methods are also provided.
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公开(公告)号：US11522952B2
公开(公告)日：2022-12-06
申请号：US16913745
申请日：2020-06-26
Inventor： Nael Abu-Ghazaleh , Weishuai Yang , Michael Lewis
IPC: H04L29/08 , H04L67/104 , G06F15/16 , H04L41/12 , H04L43/10 , H04L47/70 , H04L67/02 , H04L67/10 , H04L67/51 , G06Q10/06 , H04L45/12 , H04L45/121 , H04L45/122 , H04L47/783
Abstract: A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets.
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公开(公告)号：US11497713B2
公开(公告)日：2022-11-15
申请号：US16225629
申请日：2018-12-19
Applicant: TargaGenix, Inc. , The Research Foundation for The State University of New York , Northeastern University
Inventor： James E. Egan , Mansoor Amiji , Iwao Ojima
IPC: A61K9/107 , A61K47/54 , A61K47/44 , A61K39/395 , A61P35/00 , A61K31/337 , C07K16/28 , A61K39/00
Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
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Patent Agency Ranking
公开(公告)号：US20220339248A1
公开(公告)日：2022-10-27
申请号：US17596699
申请日：2020-02-14
Inventor： Moro O. SALIFU , Anna BABINSKA
Abstract: The present disclosure relates to methods of treating neointimal hyperplasia. The methods include selecting a subject having a blood vessel abnormality, and administering to the subject an amount of a composition, wherein the composition comprises an inhibitor of cell adhesion molecule receptor/Junctional Adhesion Molecule-A (F11R/JAM-A).
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77.发明申请公开(公告)号：US20220305025A1
公开(公告)日：2022-09-29
申请号：US17635673
申请日：2020-08-17
Applicant: The Research Foundation for The State University of New York , Molecular Targeting Technologies, Inc. , Immune Modulatory Therapies LLC
Inventor： Richard B. BANKERT , Koon Yan PAK , Brian D. GRAY , Sathy V. BALU-IYER , Raymond KELLEHER , Gautam SHENOY , Maulasri BHATTA
IPC: A61K31/555 , A61K39/395 , A61K9/127 , C07F3/06 , A61P35/00
Abstract: The present disclosure provides compounds that bind phosphatidylserine (PS). Also provided are compositions comprising the compounds and methods of using the compounds and/or compositions. The compounds and compositions may be used to treat an individual having or suspected of having cancer(s), infectious disease(s), chronic inflammation, and/or autoimmune condition(s).
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公开(公告)号：US11453914B2
公开(公告)日：2022-09-27
申请号：US16496154
申请日：2018-03-23
Applicant: QUADRANT BIOSCIENCES INC. , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK , PENN STATE RESEARCH FOUNDATION
Inventor： Steven D. Hicks , Frank A. Middleton , Richard Uhlig
IPC: C12Q1/68 , C12P19/34 , C12Q1/6883
Abstract: Provided are methods for detecting or diagnosing a traumatic brain injury or TBI by detecting concentration levels miRNAs associated with TBI in saliva. Methods for controlled and normalized comparisons of salivary miRNA concentration levels are further provided. Assay kits comprising salivary miRNAs, probes and/or primers for detecting salivary miRNAs are also provided.
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公开(公告)号：US11452291B2
公开(公告)日：2022-09-27
申请号：US15931561
申请日：2020-05-13
Inventor： David G. Davies
Abstract: One aspect of the present invention is directed to a composition. The composition includes a dispersion inducer comprising: H3C—(CH2)n—CHmCHmR, where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm. The present invention is also directed to methods of using this compound.
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公开(公告)号：US20220298103A1
公开(公告)日：2022-09-22
申请号：US17724969
申请日：2022-04-20
Inventor： Maurizio Del Poeta , Visesato Mor
IPC: C07C251/86 , A61K45/06 , A61K31/16 , A61K31/7072 , A61K38/12 , A61K31/7048 , A61K31/4196 , A01N37/28 , A61K31/166
Abstract: The present invention provides a compound having the structure:
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