公开(公告)号：US11975046B2

公开(公告)日：2024-05-07

申请号：US18343944

申请日：2023-06-29

申请人： UCB BIOPHARMA SRL ,  FIVE PRIME THERAPEUTICS, INC.

发明人： Timothy Scott Johnson ,  Breda Twomey ,  Janine Powers ,  Danielle E. Kellar

IPC分类号： A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  A61P1/00 ,  A61P1/16 ,  A61P13/12 ,  A61P17/00

CPC分类号： A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  A61P1/00 ,  A61P1/16 ,  A61P13/12 ,  A61P17/00

摘要： The present invention relates to methods for the treatment of fibrosis. The invention discloses new research which demonstrates that interferon-lambda has directly acting anti-fibrotic effects both in vitro and in vivo and may be used to provide effective new therapies for the treatment of multiple types of fibrosis.

公开(公告)号：US20240076365A1

公开(公告)日：2024-03-07

申请号：US18502188

申请日：2023-11-06

申请人： UCB BIOPHARMA SRL

发明人： NEESHA DEDI ,  BREDA TWOMEY ,  MICHAEL JOHN WRIGHT ,  GARETH CHARLES GLYNDWR DAVIES ,  DAVID JAMES MCMILLAN

IPC分类号： C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/68

CPC分类号： C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/6854 ,  A61K2039/505

摘要： This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

公开(公告)号：US11912721B2

公开(公告)日：2024-02-27

申请号：US17102790

申请日：2020-11-24

申请人： UCB Biopharma SRL ,  Sanofi

发明人： Teresa De Haro Garcia ,  Michael Deligny ,  Jag Paul Heer ,  Joanna Rachel Quincey ,  Mengyang Xuan ,  Zhaoning Zhu ,  Daniel Christopher Brookings ,  Mark Daniel Calmiano ,  Yves Evrard ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Sophie Jadot ,  Jean Keyaerts ,  Malcolm MacCoss ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Dominique Louis Leon Swinnen ,  Laurent Schio ,  Yann Foricher ,  Bruno Filoche-Romme

IPC分类号： C07D519/00 ,  C07D491/08 ,  C07D487/08 ,  C07D491/18 ,  C07D495/08 ,  C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  C07D495/18 ,  C07D513/18 ,  C07F7/18 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/55

CPC分类号： C07D519/00 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/55 ,  C07D471/18 ,  C07D487/08 ,  C07D487/18 ,  C07D491/08 ,  C07D491/18 ,  C07D493/18 ,  C07D495/08 ,  C07D495/18 ,  C07D513/18 ,  C07F7/1804

摘要： A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

公开(公告)号：US20230416350A1

公开(公告)日：2023-12-28

申请号：US18344945

申请日：2023-06-30

申请人： UCB BIOPHARMA SRL

发明人： DAVID EDWARD ORMONDE KNIGHT ,  TERENCE SEWARD BAKER ,  DAVID JAMES MCMILLAN ,  ROBERT ANTHONY GRIFFIN ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE

IPC分类号： C07K16/18 ,  C07K14/47 ,  A61P25/28

CPC分类号： C07K16/18 ,  C07K14/4711 ,  A61P25/28 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/70

摘要： The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20230374148A1

公开(公告)日：2023-11-23

申请号：US18248651

申请日：2021-10-14

申请人： UCB BIOPHARMA SRL

发明人： Stephen Edward RAPECKI ,  Ralph ADAMS ,  David Paul HUMPHREYS ,  Helen Margaret FINNEY ,  Rosemary Frances BITHELL

IPC分类号： C07K16/28 ,  C07K16/18 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07K16/289 ,  C07K16/18 ,  A61P35/00 ,  A61P35/02 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/72 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/35

摘要： The present invention provides binding molecule or molecules that are able to multimerise CD45 to induce cell death of a cell expressing CD45 without also inducing significant cytokine release. For example, the invention provides antibodies against CD45, wherein the antibodies comprise at least two different paratopes each specific for a different epitope of CD45. The antibodies may be used to cross-link CD45 on the surface of cells. The antibodies may be used in a variety of therapeutic ways including to deplete cells, for example prior to cell transplantation.

公开(公告)号：US20230331833A1

公开(公告)日：2023-10-19

申请号：US18344930

申请日：2023-06-30

申请人： UCB BIOPHARMA SRL

发明人： KERRY LOUISE TYSON ,  TERENCE SEWARD BAKER ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE ,  DAVID EDWARD ORMONDE KNIGHT

IPC分类号： C07K16/18 ,  C07K14/47 ,  A61P25/28 ,  G01N33/68

CPC分类号： C07K16/18 ,  C07K14/4711 ,  A61P25/28 ,  G01N33/6896 ,  A61K2039/505

摘要： The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20230303517A1

公开(公告)日：2023-09-28

申请号：US17786394

申请日：2020-12-22

申请人： UCB Biopharma SRL

发明人： Timothy John NORMAN ,  Douglas BYRNE ,  Julian Hugh ROWLEY ,  Giancarlo TRANI ,  Konstantinos RAMPALAKOS ,  Nathaniel Julius Thomas MONCK ,  Benedicte LALLEMAND ,  Gregory William HASLETT ,  Rickki Lee CONNELLY ,  Jag Paul HEER ,  James MADDEN ,  Oliver PHILPS ,  Selvaratnam SUGANTHAN ,  Zeshan YOUSUF ,  Richard John MEARS

IPC分类号： C07D401/14 ,  C07D221/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D409/12 ,  C07D498/10 ,  C07D471/04 ,  C07D417/12 ,  C07D413/12 ,  C07D487/04 ,  C07D405/12

CPC分类号： C07D401/14 ,  C07D221/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D409/12 ,  C07D498/10 ,  C07D471/04 ,  C07D417/12 ,  C07D413/12 ,  C07D487/04 ,  C07D405/12

摘要： The present invention relates to dihydrocyclopenta-isoquinoline-sulfonamide derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular disorders caused by the interaction of IgE with the FcεRI receptor.

公开(公告)号：USD999906S1

公开(公告)日：2023-09-26

申请号：US29796504

申请日：2021-06-24

申请人： UCB Biopharma SRL

设计人： Barry Alan Knight ,  David Francis Philbrick

摘要： FIG. 1 is a top, front, left perspective view of a gripper for auto-injector needle shield, showing our new design;
FIG. 2 is a front elevation view thereof;
FIG. 3 is a rear elevation view thereof;
FIG. 4 is a left elevation view thereof;
FIG. 5 is a right elevation view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.

公开(公告)号：US11746145B2

公开(公告)日：2023-09-05

申请号：US17136440

申请日：2020-12-29

申请人： UCB BIOPHARMA SRL

发明人： Kerry Louise Tyson ,  Terence Seward Baker ,  Georges Mairet-Coello ,  Patrick Downey ,  Jean-Philippe Courade ,  David Edward Ormonde Knight

IPC分类号： C07K16/18 ,  C07K14/47 ,  A61P25/28 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61P25/28 ,  C07K14/4711 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/2821

摘要： The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20230192900A1

公开(公告)日：2023-06-22

申请号：US17929028

申请日：2020-02-13

申请人： UCB BIOPHARMA SRL

发明人： David Alan COOK ,  Helen Margaret FINNEY ,  Stephen Edward RAPECKI

IPC分类号： C07K16/46

CPC分类号： C07K16/468 ,  C07K2317/31 ,  C07K2317/24 ,  C07K2317/94 ,  C07K2317/565

摘要： The present invention relates to multispecific antibodies against a novel targets' combination of HVEM and CD9, and their use in the treatment of cancer and infectious diseases.