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公开(公告)号：US09359296B2
公开(公告)日：2016-06-07
申请号：US14683839
申请日：2015-04-10
申请人： AbbVie Inc.
发明人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC分类号： C07D401/06 , C07D401/14 , C07D209/42 , A61K31/5377 , C07D413/14 , C07D209/34 , C07D401/12 , C07D413/06 , C07D417/04 , C07D401/04 , C07D413/12 , C07D405/06 , C07D491/113
CPC分类号： C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
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72.发明申请APOPTOSIS-INDUCING AGENT FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20160002187A1
公开(公告)日：2016-01-07
申请号：US14855176
申请日：2015-09-15
申请人： AbbVie Inc.
发明人： Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
IPC分类号： C07D277/54
CPC分类号： C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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73.发明申请公开(公告)号：US20150246914A1
公开(公告)日：2015-09-03
申请号：US14645378
申请日：2015-03-11
申请人： AbbVie Inc.
IPC分类号： C07D471/04 , C07F9/6561
CPC分类号： C07D471/04 , A61K31/18 , A61K31/44 , A61K31/496 , A61P35/00 , C07F9/65616 , Y02A50/385 , Y02A50/401 , Y02A50/411 , Y02A50/463
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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74.发明授权BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases 有权用于治疗癌症和免疫疾病的BCL-2选择性细胞凋亡诱导剂公开(公告)号：US09072748B2
公开(公告)日：2015-07-07
申请号：US14058164
申请日：2013-10-18
申请人： AbbVie Inc.
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC分类号： C07D405/06 , C07D413/06 , C07D487/04 , C07D241/04 , C07D401/06 , A61K31/5377 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D471/04 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K45/06 , C07D403/06
CPC分类号： C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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75.发明授权公开(公告)号：US09029404B2
公开(公告)日：2015-05-12
申请号：US14053544
申请日：2013-10-14
申请人： AbbVie Inc.
发明人： George A. Doherty , Steven W. Elmore , Laura A. Hexamer , Robert A. Mantei , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
IPC分类号： A61K31/404 , A61K31/416 , C07D403/14 , C07D413/14 , C07D213/76 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D211/06 , C07D295/14 , C07D309/32 , C07D403/12
CPC分类号： C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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76.发明申请公开(公告)号：US20140094471A1
公开(公告)日：2014-04-03
申请号：US14038304
申请日：2013-09-26
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC分类号： C07D471/04 , C07D403/12 , C07D209/82
CPC分类号： C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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77.发明申请公开(公告)号：US20130267534A1
公开(公告)日：2013-10-10
申请号：US13830926
申请日：2013-03-14
申请人： ABBVIE INC.
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号： C07D471/04
CPC分类号： C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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78.发明申请公开(公告)号：US20130267514A1
公开(公告)日：2013-10-10
申请号：US13831184
申请日：2013-03-14
申请人： ABBVIE INC.
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D491/052 , C07D519/00
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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