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公开(公告)号：US20090325804A1
公开(公告)日：2009-12-31
申请号：US12534470
申请日：2009-08-03
申请人： Linda A. Castle , Dan Siehl , Lorraine Giver , Jeremy Minshull , Cristina Ivy , Yong Hong Chen , Phillip A. Patten , Nicholas B. Duck , Rebecca Gorton , Billy Fred McCutchen , Roger Kemble
发明人： Linda A. Castle , Dan Siehl , Lorraine Giver , Jeremy Minshull , Cristina Ivy , Yong Hong Chen , Phillip A. Patten , Nicholas B. Duck , Rebecca Gorton , Billy Fred McCutchen , Roger Kemble
CPC分类号： C12N15/8275 , C12N9/1029 , C12N9/1092 , C12N15/8209 , C12Y205/01019
摘要： Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.
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公开(公告)号：US20090011938A1
公开(公告)日：2009-01-08
申请号：US12129947
申请日：2008-05-30
申请人： Linda A. Castle , Yong Hong Chen , Nicholas B. Duck , Lorraine Giver , Cristina Ivy , Roger Kemble , Billy Fred McCutchen , Jeremy Minshull , Phillip A. Patten , Dan Siehl
发明人： Linda A. Castle , Yong Hong Chen , Nicholas B. Duck , Lorraine Giver , Cristina Ivy , Roger Kemble , Billy Fred McCutchen , Jeremy Minshull , Phillip A. Patten , Dan Siehl
CPC分类号： C12N9/1029 , C12N15/8209 , C12N15/8275
摘要： Methods and compositions for improving yield in a plant are provided. Methods of improving yield include treating plants with an effective amount of glyphosate, wherein the plant express at least two heterologous polypeptides that impart tolerance to glyphosate via distinct modes of action. In one non-limiting method, the first polypeptide has glyphosate N-acetyl transferase activity and the second polypeptide comprises a glyphosate-tolerant EPSPS polypeptide.
摘要翻译： 提供了用于提高植物产量的方法和组合物。 提高产量的方法包括用有效量的草甘膦处理植物，其中植物表达至少两种异源多肽，其通过不同的作用模式赋予对草甘膦的耐受性。 在一个非限制性方法中，第一多肽具有草甘膦N-乙酰转移酶活性，第二多肽包含耐草甘膦EPSPS多肽。
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公开(公告)号：US07541436B2
公开(公告)日：2009-06-02
申请号：US11744424
申请日：2007-05-04
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US07531630B2
公开(公告)日：2009-05-12
申请号：US11531531
申请日：2006-09-13
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译： 本发明提供了干扰素-α多肽和缀合物，以及编码多肽的核酸。 本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。
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公开(公告)号：US07488473B2
公开(公告)日：2009-02-10
申请号：US11554377
申请日：2006-10-30
CPC分类号： C07K14/56 , A61K9/0019 , A61K38/212 , A61K47/60
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20090017502A1
公开(公告)日：2009-01-15
申请号：US11554565
申请日：2006-10-30
CPC分类号： C07K14/56 , A61K9/0019 , A61K38/212 , A61K47/60
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20090017501A1
公开(公告)日：2009-01-15
申请号：US11554547
申请日：2006-10-30
CPC分类号： C07K14/56 , A61K9/0019 , A61K38/212 , A61K47/60
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译： 本发明提供了干扰素-α多肽和缀合物，以及编码多肽的核酸。 本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。
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公开(公告)号：US20090017500A1
公开(公告)日：2009-01-15
申请号：US11554377
申请日：2006-10-30
CPC分类号： C07K14/56 , A61K9/0019 , A61K38/212 , A61K47/60
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20080227149A1
公开(公告)日：2008-09-18
申请号：US11924563
申请日：2007-10-25
CPC分类号： C07K14/56 , A61K9/0019 , A61K38/212 , A61K47/60
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译： 本发明提供了干扰素-α多肽和缀合物，以及编码多肽的核酸。 本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。
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公开(公告)号：US20120283175A1
公开(公告)日：2012-11-08
申请号：US13289212
申请日：2011-11-04
IPC分类号： A61K31/5375 , A61K31/7052 , A61K31/496 , A61K31/5377 , A61P31/04 , A61K31/546 , A61K31/7036 , A61K31/7048 , A61K31/407 , A61K38/14 , A61K31/7028
CPC分类号： A61K31/166 , A61K31/421 , A61K2300/00
摘要： The present invention provides a methods and pharmaceutical compositions useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, a synergistic combination of an inhibitor of LpxC and second antibacterial agent.
摘要翻译： 本发明提供了可用于治疗人和动物细菌感染的方法和药物组合物，其包括向有需要的人或动物施用LpxC抑制剂和第二抗菌剂的协同组合。
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