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71.
公开(公告)号:US5274094A
公开(公告)日:1993-12-28
申请号:US992269
申请日:1992-12-14
Applicant: Mark Whittaker , Andrew Miller , Stephen A. Bowles
Inventor: Mark Whittaker , Andrew Miller , Stephen A. Bowles
IPC: A61K31/415 , C07D235/08 , C07D401/12 , C07D403/12 , C07D471/04 , C07F7/18
CPC classification number: C07D401/12 , A61K31/415 , C07D235/08 , C07D403/12 , C07D471/04 , C07F7/1856
Abstract: Compounds of general formula I; ##STR1## wherein: A.sup.1 is .dbd.N--, .dbd.CH-- or .dbd.CR.sup.1 --;A.sup.2 is --N.dbd., --CH.dbd. or --CR.sup.2 .dbd.;provided that, when one of A.sup.1 and A.sup.2 is a nitrogen atom, the other of A.sup.1 and A.sup.2 is other than a nitrogen atom; wherein the rest of the variables are defined in the specification; and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment of amelioration of various diseases or disorders mediated by PAF.
Abstract translation: 通式I的化合物; 其中:A1为= N-,= CH-或CR1-; A2是-N =,-CH =或-CR2 = 条件是当A1和A2之一是氮原子时,A1和A2中的另一个不是氮原子; 其中所述变量的其余部分在说明书中定义; 其药学和兽医学上可接受的酸加成盐和水合物是血小板活化因子(PAF)的拮抗剂,因此可用于治疗由PAF介导的各种疾病或病症的改善。
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72.
公开(公告)号:US5180724A
公开(公告)日:1993-01-19
申请号:US760174
申请日:1991-09-16
Applicant: Stephen A. Bowles , Mark Whittaker , Andrew Miller
Inventor: Stephen A. Bowles , Mark Whittaker , Andrew Miller
IPC: C07C233/83 , C07C309/65 , C07C309/66 , C07C309/73 , C07D213/74 , C07D471/04
CPC classification number: C07D213/74 , C07C233/83 , C07C309/65 , C07C309/66 , C07C309/73 , C07D471/04
Abstract: Compounds of general formula I; ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, A.sup.1, A.sup.2, B, and X are variables.These compounds are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.
Abstract translation: 通式I的化合物; 其中R1,R2,R3,R4,R5,R6,R7,R8,A1,A2,B和X是变量。 这些化合物是血小板活化因子(PAF)的拮抗剂,因此可用于治疗或改善由PAF介导的各种疾病或病症。
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公开(公告)号:US20230292929A1
公开(公告)日:2023-09-21
申请号:US18324956
申请日:2023-05-27
Applicant: Andrew Miller
Inventor: Andrew Miller
Abstract: An accessory for use with a backpack or other carry-on item having a front side with one or more arm loops and a back side featuring a pocket for holding a portable head support. The accessory may be in the form of a slipcover that fits over the carry-on item. Other embodiments in which the arm loops and the pocket attach to the carry-on item using pre-existing attachment mechanisms that are built into the carry-on item are contemplated.
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公开(公告)号:US11659935B2
公开(公告)日:2023-05-30
申请号:US17826337
申请日:2022-05-27
Applicant: Andrew Miller
Inventor: Andrew Miller
Abstract: The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.
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公开(公告)号:US10548790B2
公开(公告)日:2020-02-04
申请号:US15140867
申请日:2016-04-28
Applicant: Andrew Miller , Alexander R. Vaccaro
Inventor: Andrew Miller , Alexander R. Vaccaro
Abstract: A post-surgical support member is configured to be placed a post-surgically between a supine patient and a support surface so as to isolate an anatomical load from a post-surgical wound against the support surface, the anatomical load produced by the weight of the supine patient.
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公开(公告)号:US10029059B2
公开(公告)日:2018-07-24
申请号:US13991265
申请日:2011-11-01
Applicant: Andrew Miller , Marc Berrow Gibbons
Inventor: Andrew Miller , Marc Berrow Gibbons
Abstract: Disclosed is an apparatus for condensing water from respiratory gases. The apparatus has a heat exchange component having an inlet, an outlet and a condensation chamber, the inlet and outlet being connectable to a breathing system, such that respiratory gases are conveyed through the condensation chamber, in use, and a base unit adapted to aid removal of heat from the walls of the heat exchange component. The heat exchange component is releasably engageable with the base unit, such that the heat exchange component is replaceable.
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公开(公告)号:US20170340125A1
公开(公告)日:2017-11-30
申请号:US15656455
申请日:2017-07-21
Applicant: Andrew Miller
Inventor: Andrew Miller
IPC: A47C16/00
Abstract: The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.
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公开(公告)号:US09770113B1
公开(公告)日:2017-09-26
申请号:US15078704
申请日:2016-03-23
Applicant: Andrew Miller
Inventor: Andrew Miller
IPC: A47C16/00
Abstract: The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.
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79.
公开(公告)号:US09462964B2
公开(公告)日:2016-10-11
申请号:US13242662
申请日:2011-09-23
Applicant: Marc Stein , Andrew Miller , Jason Addink , Andrew U. Chase
Inventor: Marc Stein , Andrew Miller , Jason Addink , Andrew U. Chase
CPC classification number: A61B5/1036 , A61B5/0031 , A61B5/6878 , A61B5/6882 , A61F2/38 , A61F2/389 , A61F2002/30616 , A61F2002/3067 , A61F2002/3895 , A61F2002/4666
Abstract: At least one embodiment is directed to an insert for measuring a parameter of the muscular-skeletal system. The insert can be temporary or permanent. In one embodiment, the insert is prosthetic component for a single compartment of the knee. The insert comprises a support structure and a support structure respectively having an articular surface and a load bearing surface. The height of the insert is less than 10 millimeters. At least one internal cavity is formed when support structures are coupled together for housing electronic circuitry, sensors, and the power source. The cavity can be sterilized through a port. A membrane is between the port and the cavity. A sterilization gas permeates the membrane for sterilizing cavity. The membrane reduces the ingress of solids and liquids to the cavity.
Abstract translation: 至少一个实施例涉及用于测量肌肉 - 骨骼系统的参数的插入件。 插入可以是临时的或永久的。 在一个实施例中,插入件是用于膝盖的单个隔室的假体部件。 插入件包括分别具有关节表面和承载表面的支撑结构和支撑结构。 刀片的高度小于10毫米。 当支撑结构耦合在一起以容纳电子电路,传感器和电源时,形成至少一个内部空腔。 空腔可以通过端口进行灭菌。 隔膜位于端口和腔体之间。 灭菌气体渗透膜用于消毒空腔。 膜减少了固体和液体进入腔体。
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公开(公告)号:US08637511B2
公开(公告)日:2014-01-28
申请号:US12796297
申请日:2010-06-08
Applicant: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
Inventor: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC: A61K31/506 , A61K31/5355 , A61P29/00 , A61P19/08 , A61P3/00 , A61P25/28 , A61P35/00 , A61P9/00 , A61P37/08
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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