公开(公告)号：US5922874A

公开(公告)日：1999-07-13

申请号：US122160

申请日：1998-07-24

Applicant: Joachim Komoschinski ,  Helmut Fiege ,  Bernhard Beitzke

Inventor： Joachim Komoschinski ,  Helmut Fiege ,  Bernhard Beitzke

IPC: C07D295/04 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/096 ,  C07D295/13 ,  C07D295/073

CPC classification number: C07D295/096 ,  C07D295/088

Abstract: N-aryl-N'-alkyl-piperazines are obtained in a particularly simple manner, in good yields and in short reaction times when an aniline is reacted under pressure with an N-alkyl-bishydroxyethyl-amine in the presence of a strong acid.

Abstract translation: 在强酸存在下苯胺在压力下与N-烷基 - 二羟乙基胺反应时，以良好的收率和短的反应时间，以特别简单的方式获得N-芳基-N'-烷基 - 哌嗪。

公开(公告)号：US5869735A

公开(公告)日：1999-02-09

申请号：US729461

申请日：1996-10-11

Applicant: Stefan Antons ,  Erich Hammerschmidt ,  Heinz Ulrich Blank ,  Helmut Fiege ,  Heinz-Gerd Hartges

Inventor： Stefan Antons ,  Erich Hammerschmidt ,  Heinz Ulrich Blank ,  Helmut Fiege ,  Heinz-Gerd Hartges

IPC: C07C51/367 ,  C07C65/21 ,  C07C67/08 ,  C07C67/31 ,  C07C69/734 ,  C07C69/76

CPC classification number: C07C51/367 ,  C07C67/31

Abstract: Process for the preparation of alkyl aryl ethers containing carboxyl groups which are suitable for the preparation of colour film couplers, or derivatives thereof, by reaction of aromatic alcohols with alkyl halides containing carboxyl groups or derivatives thereof and basic alkali metal or alkaline earth metal compounds, characterized in that the reaction is carried out in the melt of the aromatic alcohol.

Abstract translation: 通过芳香族醇与含有羧基的烷基卤化物或其衍生物和碱性碱金属或碱土金属化合物的反应制备适用于制备彩色成色剂或其衍生物的含羧基的烷基芳基醚的方法， 其特征在于反应在芳族醇的熔体中进行。

公开(公告)号：US5847234A

公开(公告)日：1998-12-08

申请号：US873532

申请日：1997-06-12

Applicant: Horst Behre ,  Helmut Fiege ,  Gunter Rauchschwalbe

Inventor： Horst Behre ,  Helmut Fiege ,  Gunter Rauchschwalbe

IPC: C07C37/04 ,  C07C39/15 ,  C07C39/12

CPC classification number: C07C37/04

Abstract: 4-Hydroxybiphenyl is obtained in non-thixotropic form if a reaction mixture which is obtained by alkaline hydrolysis of biphenyl-4-sulfonic acid and contains 4-hydroxybiphenyl is heated at elevated pressure at above 115.degree. C. and at a pH from 0 to below 6.5.

Abstract translation: 如果通过联苯基-4-磺酸的碱水解得到并含有4-羟基联苯的反应混合物在高于115℃的高压下和在0至0℃的pH下加热，则以非触变形式获得4-羟基联苯 低于6.5。

公开(公告)号：US5756809A

公开(公告)日：1998-05-26

申请号：US742074

申请日：1996-11-01

Applicant: Ferdinand Hagedorn ,  Helmut Fiege

Inventor： Ferdinand Hagedorn ,  Helmut Fiege

IPC: C07B53/00 ,  C07C319/14 ,  C07C319/18 ,  C07C323/56 ,  C07C149/40

CPC classification number: C07C319/14 ,  C07C319/18

Abstract: (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4"-methoxyphenyl)-propionic acid methyl ester, an important precursor for the preparation of the pharmaceutical active substance diltiazem, is obtained in a particularly high stereoselectivity and yield by addition of o-aminothiophenol onto 3-(4'-methoxyphenyl)-glycidic acid methyl ester if the reaction is carried out in the presence of alkali metal salts of weak acids in the presence of catalytic amounts of iron compounds.

Abstract translation: （2RS，3RS）-3-（2'-氨基苯硫基）-2-羟基-3-（4“ - 甲氧基苯基） - 丙酸甲酯，是制备药物活性物质地尔硫卓的重要前体 如果反应在弱酸的碱金属盐存在下，在催化量的存在下，在3-（4'-甲氧基苯基） - 缩水甘油酸甲酯中加入邻氨基苯硫酚，则具有特别高的立体选择性和产率 铁化合物。

公开(公告)号：US5679826A

公开(公告)日：1997-10-21

申请号：US735717

申请日：1996-10-23

Applicant: Franz-Josef Mais ,  Thomas Essert ,  Helmut Fiege ,  Friedrich Durholz ,  Guido Steffan

Inventor： Franz-Josef Mais ,  Thomas Essert ,  Helmut Fiege ,  Friedrich Durholz ,  Guido Steffan

IPC: B01J31/02 ,  C07B61/00 ,  C07C253/30 ,  C07C255/10

CPC classification number: C07C253/30

Abstract: 2-Chloroacrylonitrile is prepared in a particularly advantageous and readily industrially practicable manner by chlorinating acrylonitrile and then thermally cleaving the 2,3-diehloropropionitrile formed, by chlorinating acrylonitrile in the presence of a catalyst system comprising dimethylformamide and pyridine and/or pyridine derivatives and subjecting the resulting crude 2,3-dichloropropionitrile to thermal cleavage in the presence of the same catalyst system without the addition of further catalysts.

Abstract translation: 通过氯化丙烯腈，然后在包含二甲基甲酰胺和吡啶和/或吡啶衍生物的催化剂体系存在下，通过氯化丙烯腈热分解形成的2,3-二氯丙腈，制备2-氯丙烯腈， 所得粗制的2,3-二氯丙腈在相同的催化剂体系的存在下进行热裂解而不加入另外的催化剂。

公开(公告)号：US5659088A

公开(公告)日：1997-08-19

申请号：US456839

申请日：1995-06-01

Applicant: Helmut Fiege ,  Ferdinand Hagedorn ,  Wolfgang Eymann ,  Otto Neuner ,  Herbert Muller

Inventor： Helmut Fiege ,  Ferdinand Hagedorn ,  Wolfgang Eymann ,  Otto Neuner ,  Herbert Muller

IPC: C07C313/14 ,  C07C319/06 ,  C07C319/24 ,  C07C323/09 ,  C07C319/02 ,  C07C319/14

CPC classification number: C07C319/06 ,  C07C313/14 ,  C07C319/24

Abstract: 4-Fluorothiophenol is obtained in outstanding purifies and yields if 4-fluorobenzenesulphonyl chloride is reacted with sodium hydrogen sulphite solution to give a solution of sodium 4-fluorobenzenesulphinate, this solution is reduced with sulphur dioxide to give 4,4'-difluorodiphenyl disulphide and finally this is reacted with sodium borohydride in a water-miscible inert organic solvent to give 4-fluorothiophenol (sodium salt). Free 4-fluorothiophenol can be isolated from the sodium salt solution by acidification.

Abstract translation: 如果将4-氟苯磺酰氯与亚硫酸氢钠溶液反应，得到4-氟苯磺酸钠溶液，得到4-氟苯硫酚，该溶液用二氧化硫还原得到4,4'-二氟二苯基二硫化物 将其与硼氢化钠在水混溶惰性有机溶剂中反应，得到4-氟苯硫酚（钠盐）。 游离的4-氟代苯硫酚可以通过酸化从钠盐溶液中分离出来。

公开(公告)号：US5629441A

公开(公告)日：1997-05-13

申请号：US514277

申请日：1995-08-11

Applicant: Helmut Kraus ,  Horst Behre ,  Helmut Fiege

Inventor： Helmut Kraus ,  Horst Behre ,  Helmut Fiege

IPC: C07D213/74 ,  C07C253/30 ,  C07C255/61 ,  C07C319/20 ,  C07C323/45 ,  C07D239/28 ,  C07C255/00

CPC classification number: C07D239/28 ,  C07C255/61

Abstract: 2-(Arylimino-methyl)-3-dialkylaminoacrylonitriles can be obtained by reaction of .beta.-anilino-acrylonitriles with ortho-formamides. They are suitable as starting substances for the preparation of 4-amino-5-iminiummethylene-2-pyrimidines or 4-amino-5-formyl-2-pyrimidines.

Abstract translation: 2-（芳基亚氨基 - 甲基）-3-二烷基氨基丙烯腈可以通过β-苯胺基丙烯腈与邻甲酰胺的反应获得。 它们适用于制备4-氨基-5-亚氨基亚甲基-2-嘧啶或4-氨基-5-甲酰基-2-嘧啶的起始物质。

公开(公告)号：US5523481A

公开(公告)日：1996-06-04

申请号：US347660

申请日：1994-12-01

Applicant: Michael Pies ,  Helmut Fiege ,  Josef Kasbauer ,  Gebhard Merz

Inventor： Michael Pies ,  Helmut Fiege ,  Josef Kasbauer ,  Gebhard Merz

IPC: B01J31/02 ,  C07B61/00 ,  C07C68/02 ,  C07C69/96 ,  C07C51/56 ,  C07C51/54

CPC classification number: C07C68/02

Abstract: Dialkyl dicarbonates are obtained particularly advantageously from halogenoformic esters by reaction with alkalis in the presence of water-immiscible organic solvents and in the presence of a catalyst, if the catalyst used is benzylalkyldimethylammonium halides. The catalyst is then particularly easy to separate off and to recycle from the reaction mixture.

Abstract translation: 如果所用的催化剂是苄基烷基二甲基卤化铵，则在与水不混溶的有机溶剂的存在下和在催化剂存在下，通过与碱反应，特别有利地从卤代甲酸酯获得二烷基二烷基酯。 然后催化剂特别容易分离并从反应混合物中再循环。

公开(公告)号：US5384059A

公开(公告)日：1995-01-24

申请号：US110343

申请日：1993-08-20

Applicant: Alfons Klein ,  Rudolf Kron ,  Helmut Fiege ,  Klaus-Christian Paetz

Inventor： Alfons Klein ,  Rudolf Kron ,  Helmut Fiege ,  Klaus-Christian Paetz

IPC: C09K5/08 ,  C07C2/86 ,  C07C5/11 ,  C07C13/28 ,  C07C2/66 ,  C07C13/18

CPC classification number: C07C13/28 ,  C07C2/864 ,  C07C5/11 ,  C07C2101/14 ,  C07C2521/08

Abstract: Mixtures consisting essentially of cyclohexylbiphenyls, dicyclohexylbenzenes, phenylbicyclohexyls and tercyclohexyls are outstandingly suitable as heat transfer media. The mixtures can be prepared from biphenyl and cyclohexanol in the presence of bleaching earths and subsequent hydrogenation.

Abstract translation: 基本上由环己基联苯，二环己基苯，苯基双环己基和三环己基组成的混合物非常适合作为传热介质。 混合物可以在漂白土和随后的氢化存在下由联苯和环己醇制备。

公开(公告)号：US5157170A

公开(公告)日：1992-10-20

申请号：US805433

申请日：1991-12-11

Applicant: Franz-Josef Mais ,  Helmut Fiege

Inventor： Franz-Josef Mais ,  Helmut Fiege

IPC: B01J23/50 ,  B01J23/72 ,  C07B61/00 ,  C07C17/00 ,  C07C17/12 ,  C07C25/02

CPC classification number: C07C17/00

Abstract: The halogen of a polyhalogenated aromatic compound can be transferred to a monohalogenated or nonhalogenated aromatic compound by reaction in the presence of ruthenium as the element or in the form of compounds and if desired with one or more metal compounds from subgroups I and II of the Periodic Table.

Abstract translation: 多卤代芳族化合物的卤素可以通过在钌作为元素或化合物的形式存在下反应而转化为单卤代或非卤代芳族化合物，如果需要，可以与周期表的第I和II族的一种或多种金属化合物 表。