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71.发明申请公开(公告)号：US20140016722A1
公开(公告)日：2014-01-16
申请号：US14009338
申请日：2011-04-26
申请人： Hideyuki Torimoto , Makoto Ishii , Masahiro Asako , Hiroaki Maeda
发明人： Hideyuki Torimoto , Makoto Ishii , Masahiro Asako , Hiroaki Maeda
IPC分类号： H04L7/00
CPC分类号： H04L7/0091 , G01S1/20 , G01S5/021 , G01S5/0226 , G01S19/10 , G01S19/11
摘要： Provided is a navigation signal transmitter capable of ensuring reduction in frequency deviation of a terrestrially transmitted navigation signal at low cost. The navigation signal transmitter is operable to receive a transmission wave, generate a synchronization pulse in synchronization with a predetermined data frame, generate an internal clock fundamental oscillation by a reference signal synchronizing section (550) using the synchronization pulse as a reference signal, generate an IMES signal based on the internal clock fundamental oscillation, and transmit the IMES signal. The reference signal synchronizing section (550) comprises a counter circuit (551), a comparator (553), a low-pass control filter (554), a D/A converter (555) and a voltage controlled oscillator (556). The reference signal synchronizing section (550) is configured to, when a magnitude relationship between the number of clock pulses generated in the voltage controlled oscillator (556) using the synchronization pulse as the reference signal and a reference value falls within a predetermined value and continues a predetermined number of times in one direction, adjust a level of control voltage of the voltage controlled oscillator (556).
摘要翻译： 提供能够以低成本确保地面传输的导航信号的频率偏差的导航信号发射机。 导航信号发射器可操作以接收发射波，与预定数据帧同步产生同步脉冲，使用同步脉冲作为参考信号，通过参考信号同步部分（550）产生内部时钟基本振荡，生成 IMES信号基于内部时钟基波振荡，并传输IMES信号。 参考信号同步部分（550）包括计数器电路（551），比较器（553），低通控制滤波器（554），D / A转换器（555）和压控振荡器（556）。 参考信号同步部分（550）被配置为当使用作为参考信号的同步脉冲的压控振荡器（556）中产生的时钟脉冲数与基准值之间的幅度关系落在预定值内并继续 在一个方向上预定次数，调节压控振荡器（556）的控制电压的电平。
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公开(公告)号：US08364101B2
公开(公告)日：2013-01-29
申请号：US12721064
申请日：2010-03-10
CPC分类号： H03F1/0288 , H03F1/0222 , H03F1/3247 , H03F2201/3233
摘要： An amplifying device includes an amplifier including a first amplifying element with a drain voltage thereof being controlled, and a second amplifying element, the amplifier amplifying a transmission signal with the first and second amplifying elements, synthesizing the transmission signals amplified by the first and second amplifying elements, and outputting the synthesized transmission signal; a distortion compensator part which performs distortion compensation on the input signal in accordance with a compensation coefficient derived from a difference between a input signal and a feedback signal generated from a portion of a signal output from the amplifier; and a controller part which controls the drain voltage of the first amplifying element in response to a result of a comparison between a power level of the input signal prior to the distortion compensation operation by the distortion compensator part and a threshold value.
摘要翻译： 一种放大装置，包括：放大器，包括其漏极电压被控制的第一放大元件;以及第二放大元件，放大器利用第一和第二放大元件放大发送信号，合成由第一和第二放大元件放大的发送信号 并输出合成的发送信号; 失真补偿部，其根据从输入信号和从放大器输出的信号的一部分产生的反馈信号之间的差导出的补偿系数，对输入信号进行失真补偿; 以及控制器部分，其响应于在失真补偿器部分的失真补偿操作之前的输入信号的功率电平与阈值之间的比较的结果来控制第一放大元件的漏极电压。
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73.发明授权Process for producing recombinant fibrinogen highly producing cell and highly producing cell 有权用于生产重组纤维蛋白原高产细胞和高产细胞的方法公开(公告)号：US08283137B2
公开(公告)日：2012-10-09
申请号：US10566266
申请日：2004-07-28
申请人： Reiko Matsuyama , Hiroaki Maeda
发明人： Reiko Matsuyama , Hiroaki Maeda
CPC分类号： C07K14/75
摘要： When genes encoding three kinds of proteins constituting fibrinogen, an α chain (or variant of α chain), a β chain and a γ chain (or variant of γ chain) are incorporated into an animal cell, a constitutional ratio of respective genes is such that a α chain (and/or variant of γ chain) gene is an equal amount to a 1000-fold amount relative to an α chain (and/or variant of α chain) gene and a β chain gene and, further, by using a baculovirus P35 gene, a recombinant fibrinogen highly producing cell is prepared.
摘要翻译： 当编码构成纤维蛋白原的三种蛋白质的基因，α链（或α链的变体），a＆bgr; 链和γ链（或γ链的变体）并入动物细胞中，各基因的构成比例使得α链（和/或γ链的变体）基因等于1000倍 相对于α链（和/或α链的变体）基因和bgr的量; 链基因，并且通过使用杆状病毒P35基因，制备重组纤维蛋白原高产细胞。
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公开(公告)号：US20120225818A1
公开(公告)日：2012-09-06
申请号：US13389215
申请日：2010-08-05
申请人： Shintaro Kamei , Asami Shindome , Takayoshi Hamamoto , Hiroaki Maeda , Masaki Hirashima , Sachio Okuda , Misako Umehashi , Sachie Ogawa , Megumi Imuta , Norio Akaike , Kazuo Takahama , Ryoko Wada
发明人： Shintaro Kamei , Asami Shindome , Takayoshi Hamamoto , Hiroaki Maeda , Masaki Hirashima , Sachio Okuda , Misako Umehashi , Sachie Ogawa , Megumi Imuta , Norio Akaike , Kazuo Takahama , Ryoko Wada
CPC分类号： C12N9/6443 , A61K38/4846
摘要： The activated Factor XI is provided as an antitussive for cough caused by the stimulation at the tracheal bifurcation such as chronic cough. A pharmaceutical composition for prevention, treatment and/or symptom amelioration of cough, comprising a polypeptide chain as an active ingredient and a pharmaceutically acceptable carrier, wherein the polypeptide chain consists of a full length amino acid sequence constituting activated Factor XI (hereinafter also referred to as “FXIa”), the amino acid sequence with one or several amino acids therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.
摘要翻译： 提供活化因子XI作为由气管分叉如慢性咳嗽引起的咳嗽的镇咳药。 一种用于预防，治疗和/或症状改善咳嗽的药物组合物，其包含多肽链作为活性成分和药学上可接受的载体，其中所述多肽链由构成活化因子XI的全长氨基酸序列组成（以下也称为 作为“FXIa”），其中具有一个或几个氨基酸的氨基酸序列被缺失，取代或加入，或任一上述氨基酸序列的部分序列，或包含上述任何一种的氨基酸序列 氨基酸序列。
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公开(公告)号：US07972835B2
公开(公告)日：2011-07-05
申请号：US12369329
申请日：2009-02-11
申请人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
发明人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
CPC分类号： C12N9/54
摘要： A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine, leucine, glycine, tyrosine aspartic, acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysine, glutamic acid, lysine, tyrosine, arginine, glycine, tyrosine, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, tyrosine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, tyrosine, aspartic acid, aspartic acid, leucine, alanine, histidine, glycine, threonine, histidine, valine, and threonine, a second structural amino acid sequence having alanine, phenylalanine, serine, glutamic acid, aspartic acid, glycine, glycine, threonine, aspartic acid, alanine, aspartic acid, isoleucine, leucine, glutamic acid, alanine, glycine, glutamic acid, tryptophan, valine, and leucine, a third structural amino acid sequence having aspartic acid, alanine, glutamic acid, glycine, asparagine, proline, histidine, proline, glutamic acid, methionine, alanine, proline, aspartic acid, and valine, and a fourth structural amino acid sequence having valine, proline, glycine, glutamine, alanine, tyrosine, glutamic acid, aspartic acid, glycine, tryptophan, and aspartic acid, thereby reducing the viscosity of whole blood.
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76.发明授权Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity 失效具有细胞毒性抑制活性的肽和筛选具有细胞毒性抑制活性的肽的方法公开(公告)号：US07960508B2
公开(公告)日：2011-06-14
申请号：US10477101
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
摘要翻译： 含有一种或多种硒代半胱氨酸的肽片段或一系列肽片段，其毒性低于硒代胱氨酸并且具有细胞毒性抑制活性。 根据本发明的肽片段或一系列肽片段优选具有来自硒蛋白P的C末端的第260至第362位氨基酸残基的氨基酸序列，或其中具有一个或几个氨基酸残基的所述氨基酸序列是 缺失，取代或添加，或上述氨基酸序列中的任一个的部分序列，或包含作为上述氨基酸序列之一的氨基酸序列。 还提供了具有细胞毒性抑制活性的肽片段的筛选方法。
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公开(公告)号：US20110068882A1
公开(公告)日：2011-03-24
申请号：US12881367
申请日：2010-09-14
IPC分类号： H01P1/20
CPC分类号： H01P1/2039 , H01P1/212 , H03F1/56 , H03F3/601 , H03F2200/387 , H03F2200/423
摘要： There is provided a filter which includes a transmission line, a stub branched from the transmission line, the stub electrically coupled with the transmission line, and a resonator configured to electromagnetically couple with the stub and to resonate at an odd harmonic frequency of a fundamental wave, the fundamental wave propagating through the transmission line.
摘要翻译： 提供一种滤波器，其包括传输线，从传输线分支的短截线，与传输线电耦合的短截线，以及谐振器，被配置为与短截线电磁耦合并以基波的奇次谐波频率谐振 ，基波通过传输线传播。
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公开(公告)号：US20110064475A1
公开(公告)日：2011-03-17
申请号：US12881822
申请日：2010-09-14
申请人： Ryuji YOSHIDA , Mikio Ishibashi , Nobuyuki Koinuma , Hideki Zenba , Naoyuki Ozaki , Hiroaki Maeda , Mugijirou Uno , Shunichi Hashimoto , Yoshinori Nakagawa , Tomoko Takahashi
发明人： Ryuji YOSHIDA , Mikio Ishibashi , Nobuyuki Koinuma , Hideki Zenba , Naoyuki Ozaki , Hiroaki Maeda , Mugijirou Uno , Shunichi Hashimoto , Yoshinori Nakagawa , Tomoko Takahashi
IPC分类号： G03G15/08
CPC分类号： G03G15/0126 , G03G15/0868 , G03G15/0872 , G03G15/0879 , G03G15/0886 , G03G2215/0604 , G03G2221/163 , G03G2221/1815
摘要： An image forming apparatus includes a first image formation unit that forms a black toner image, and a detachable second image formation unit that forms a color toner image. A first toner supply unit is provided to supply the black toner to the first image formation unit. A second toner supply unit is provided to supply one of a black and component color toner to the first and second image formation units in accordance with a color mode. A first conveyance path is provided to convey the black toner to the first image formation unit. A second conveyance path is also provided to convey the component color toner stored in the second toner container section to the second image formation unit. The second toner supply unit is selectively connected to one of the first and second conveyance paths in accordance with the color mode.
摘要翻译： 图像形成装置包括形成黑色调色剂图像的第一图像形成单元和形成彩色调色剂图像的可拆卸第二图像形成单元。 提供第一调色剂供应单元以将黑色调色剂供应到第一图像形成单元。 提供第二调色剂供应单元，以根据颜色模式向黑色和彩色调色剂中的一种提供第一和第二图像形成单元。 提供第一输送路径以将黑色调色剂输送到第一图像形成单元。 还提供第二传送路径以将存储在第二调色剂容器部分中的部件颜色调色剂传送到第二图像形成单元。 第二调色剂供应单元根据颜色模式选择性地连接到第一和第二输送路径中的一个。
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公开(公告)号：US07704951B2
公开(公告)日：2010-04-27
申请号：US12081991
申请日：2008-04-24
IPC分类号： A61K38/02 , A61K38/18 , A61K31/095
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译： 提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。 根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。
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公开(公告)号：US20090243626A1
公开(公告)日：2009-10-01
申请号：US12401734
申请日：2009-03-11
IPC分类号： G01R31/02
CPC分类号： H03F1/523 , H03F1/0288
摘要： An amplification apparatus including a plurality of amplifiers includes a carrier amplifier, a peak amplifier including a gate bias circuit including a resistor for supplying a gate bias voltage, a comparator for outputting a resultant signal determined by comparison of a predetermined threshold voltage with a voltage across the resistor included within the gate bias circuit, and a failure detecting circuit for detecting whether a failure in the plurality of amplifiers is caused or not based on the resultant signal.
摘要翻译： 包括多个放大器的放大装置包括载波放大器，包括栅极偏置电路的峰值放大器，该栅极偏置电路包括用于提供栅极偏置电压的电阻器，比较器，用于输出通过比较预定阈值电压确定的合成信号 包括在栅极偏置电路内的电阻器，以及用于根据所得到的信号检测是否引起多个放大器的故障的故障检测电路。
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