公开(公告)号：US20120329830A1

公开(公告)日：2012-12-27

申请号：US13511359

申请日：2010-11-19

Applicant: Yuan Cheng ,  Timothy Powers ,  Kate Ashton ,  James Brown ,  Scott Harried ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Thomas Nixey ,  Nick A. Paras ,  Steve F. Poon ,  David J. St. Jean, JR. ,  Qiufen Xue ,  Wenge Zhong

Inventor： Yuan Cheng ,  Timothy Powers ,  Kate Ashton ,  James Brown ,  Scott Harried ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Thomas Nixey ,  Nick A. Paras ,  Steve F. Poon ,  David J. St. Jean, JR. ,  Qiufen Xue ,  Wenge Zhong

IPC: C07D215/38 ,  C07D405/10 ,  A61K31/4709 ,  C07D401/10 ,  A61K31/47 ,  C07D417/10

CPC classification number: C07D215/38 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  C07D417/04

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B1, B2, B3, L, R1, R4, R5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，R 5和m如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

公开(公告)号：US08337818B2

公开(公告)日：2012-12-25

申请号：US11260116

申请日：2005-10-27

Applicant: Nora Lin ,  John Curtis ,  James Brown

Inventor： Nora Lin ,  John Curtis ,  James Brown

IPC: A61K8/00 ,  A61K8/18 ,  A61Q11/00

CPC classification number: A61K8/042 ,  A61K8/046 ,  A61K8/31 ,  A61Q11/00

Abstract: A post foaming oral care mousse is provided by the invention. The mousse includes at least a dentifrice composition and a compressed liquid propellant having a boiling point less than −10° C. The liquid propellant is blended into the mousse as an emulsion, and the emulsion is adapted to be dispensed from a container as a gel that foams after a time delay. The mousse has a viscosity of less than 30,000 centipoise when measured prior to the addition of the propellant. Preferably, the mousse expands at least 100 vol % in less than 5 seconds upon exposure to atmospheric pressure.

Abstract translation: 本发明提供一种后发泡口腔护理摩丝。 摩丝包括至少一种洁牙剂组合物和沸点小于-10℃的压缩液体推进剂。液体推进剂作为乳液混合到摩丝中，并且乳液适于作为凝胶从容器中分配 泡沫时间延迟。 在添加推进剂之前测量时，摩丝的粘度小于30,000厘泊。 优选地，摩尔在暴露于大气压力下在少于5秒内膨胀至少100体积％。

公开(公告)号：US20120294882A1

公开(公告)日：2012-11-22

申请号：US13574816

申请日：2011-01-27

Applicant: Normand Blais ,  James Brown ,  Anne-Marie Gelinas ,  Pascal Mettens ,  Dennis Murphy

Inventor： Normand Blais ,  James Brown ,  Anne-Marie Gelinas ,  Pascal Mettens ,  Dennis Murphy

IPC: A61K38/16 ,  A61P31/06 ,  C07H21/04 ,  A61K31/7088 ,  C07K14/35

CPC classification number: C07K14/35 ,  A61K39/04 ,  C07K2319/00

Abstract: Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis.

Abstract translation: 改良的Rv3616c蛋白及其用作药物，特别是用于预防结核病的再活化。

公开(公告)号：US20120230753A1

公开(公告)日：2012-09-13

申请号：US13455620

申请日：2012-04-25

Applicant: Jack W. Kaufman ,  James Brown

Inventor： Jack W. Kaufman ,  James Brown

IPC: A61M35/00

CPC classification number: A61M35/006 ,  A45D34/042 ,  A61M35/003 ,  B43M11/06

Abstract: Disclosed is a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract translation: 公开了一种手持式分配施加器，其包括流体源，连接到流体源的易碎施用器尖端和附接到易碎施用器尖端的吸收构件。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎的施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及其间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US20120126061A1

公开(公告)日：2012-05-24

申请号：US13388144

申请日：2010-08-02

Applicant: Hugo Alexandre Duart Mendes Raposeiro ,  Bruno Stefes ,  Holger Bammann ,  Thomas Selchert ,  James Brown ,  Heiko Rothe ,  Alexander Solntsev

Inventor： Hugo Alexandre Duart Mendes Raposeiro ,  Bruno Stefes ,  Holger Bammann ,  Thomas Selchert ,  James Brown ,  Heiko Rothe ,  Alexander Solntsev

IPC: B64D13/00

CPC classification number: B64D13/00 ,  B64C1/1453

Abstract: An aircraft comprises an outer aerodynamic surface and an exhaust duct having an opening in the outer aerodynamic surface. The duct has a duct wall curved at the opening so as to blend with the aerodynamic surface downstream of the duct. At least one fixed flow diverter is provided for diverting high temperature exhaust gas exiting the duct away from the aerodynamic surface immediately downstream of the duct opening. The curved duct wall provides low aerodynamic drag in cruise. The flow diverter(s) give aircraft designers freedom in terms of where the duct opening can be positioned without compromising the structural integrity of the aircraft through excessive heating of the aerodynamic surface immediately downstream of the duct opening.

Abstract translation: 飞行器包括外部空气动力学表面和在外部空气动力学表面中具有开口的排气管道。 管道具有在开口处弯曲的管道壁，以便与管道下游的空气动力学表面混合。 提供至少一个固定流量分流器，用于将离开管道的高温废气远离管道开口下游的空气动力学表面。 弯曲的管道壁在巡航中提供低气动阻力。 流量分配器使得飞机设计者在管道开口可以被定位的位置方面是自由的，而不会通过在管道开口的紧下游的空气动力学表面的过度加热来牺牲飞行器的结构完整性。

公开(公告)号：US20110316741A1

公开(公告)日：2011-12-29

申请号：US13193863

申请日：2011-07-29

Applicant: Mangesh Chansarkar ,  Sundar Raman ,  Charles P. Norman ,  Paul A. Underbrink ,  Henry D. Falk ,  James Brown ,  Robert Harvey ,  Peter Michali ,  Williams Higgins ,  Gensheng Zhang ,  Qingwen Zhang

Inventor： Mangesh Chansarkar ,  Sundar Raman ,  Charles P. Norman ,  Paul A. Underbrink ,  Henry D. Falk ,  James Brown ,  Robert Harvey ,  Peter Michali ,  Williams Higgins ,  Gensheng Zhang ,  Qingwen Zhang

IPC: G01S19/34 ,  G01S19/37

CPC classification number: G01S19/13 ,  G01S19/24 ,  G01S19/34 ,  G01S19/37 ,  H04B1/707 ,  H04B2201/70715

Abstract: Control and feature systems for processing signals from a satellite positioning system include an expert system receiver manager; a joint detection, carrier centering and bit sync acquisition subsystem; peak detection; a multi-dimensional measurement interpolation subsystem; a system for mode switching between a navigational signal; and power control module for receiver.

Abstract translation: 用于处理来自卫星定位系统的信号的控制和特征系统包括专家系统接收器管理器; 联合检测，载波中心和位同步采集子系统; 峰值检测; 多维测量插值子系统; 用于导航信号之间的模式切换的系统; 和接收机的电源控制模块。

公开(公告)号：US08056931B2

公开(公告)日：2011-11-15

申请号：US12137862

申请日：2008-06-12

Applicant: Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

Inventor： Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

IPC: G09F3/04

CPC classification number: G09F3/005

Abstract: A multi-part form includes a wristband with related tags and labels. The tags are configured for mounting on the wristband after the wristband has been secured to a person of object to be identified. The multi-part form is also configured with a wristband portion separate from a plurality of utility groups, each of which is separate from the other, by a street devoid of media layer. The layers that comprise the multi-part form are preferably solvent resistant so as to make the identification products more durable and longer lasting.

Abstract translation: 多部分形式包括带有相关标签和标签的腕带。 在将腕带固定到要识别的物体的人之后，标签被配置为安装在腕带上。 多部分形式还配置有与多个公用事业组分离的腕带部分，每个公用事业组中的每一个都是与没有媒体层的街道分离的。 构成多部分形式的层优选是耐溶剂的，以使识别产品更耐用和更持久。

公开(公告)号：US07949479B2

公开(公告)日：2011-05-24

申请号：US11989588

申请日：2006-07-13

Applicant: James Brown ,  Francis Heyes ,  Ulf Nilsson ,  Stephen Wilson

Inventor： James Brown ,  Francis Heyes ,  Ulf Nilsson ,  Stephen Wilson

IPC: G01B3/44 ,  G01K1/02

CPC classification number: G07C3/00

Abstract: A rotating machine, has a rotary component, which includes a memory device for storing data relating to the past use of the component. The data are associated with rotational speed and ambient temperature, which are detected by detectors either on or off the rotary component. The stored data may be the raw temperature and speed data as sampled over time, which are then used to derive values of low-cycle fatigue and creep damage. These fatigue and creep values are, in turn, correlated with the load profiles of the component to arrive at a value of elapsed lifespan for the component. Alternatively, the stored data may be the fatigue and creep values and/or, preferably, values of elapsed and remaining lifespan of the component. In a second embodiment the detectors are located on the machine casing along with an evaluation unit.

Abstract translation: 旋转机具有旋转部件，该旋转部件包括用于存储与部件的过去使用有关的数据的存储装置。 数据与旋转速度和环境温度相关联，旋转速度和环境温度由旋转部件上或旋转部件上的检测器检测。 存储的数据可以是随时间采样的原始温度和速度数据，然后用于导出低周疲劳和蠕变损伤的值。 这些疲劳和蠕变值又与组件的负载曲线相关联，以获得组件的使用寿命值。 或者，所存储的数据可以是组件的疲劳和蠕变值和/或优选地，经过和剩余寿命的值。 在第二实施例中，检测器与评估单元一起位于机器壳体上。

公开(公告)号：US07946779B2

公开(公告)日：2011-05-24

申请号：US12579728

申请日：2009-10-15

Applicant: Jack W. Kaufman ,  James Brown

Inventor： Jack W. Kaufman ,  James Brown

IPC: B43K5/14

CPC classification number: A61M35/006 ,  A61M35/003 ,  A61M2210/04 ,  B43M11/06

Abstract: The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract translation: 本发明涉及包括流体源，连接到流体源的易碎施用器尖端和连接到易碎施用器尖端的吸收构件的手持分配施用器。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及它们之间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US20100326464A1

公开(公告)日：2010-12-30

申请号：US12871286

申请日：2010-08-30

Applicant: Pejman Fani ,  Mark Rouillard ,  John Korbler ,  James Brown ,  Chad Hosack

Inventor： Pejman Fani ,  Mark Rouillard ,  John Korbler ,  James Brown ,  Chad Hosack

IPC: B08B3/12

CPC classification number: H01L21/02057 ,  B08B3/04 ,  B08B3/10 ,  B08B3/12 ,  H01L21/67051

Abstract: A system, apparatus and method for processing flat articles with acoustical energy. The inventive system, apparatus and method can remove particles from both sides of a wafer more efficiently and effectively. In one aspect, the invention is a system and/or method for processing flat articles wherein a liquid is applied to both major surfaces of the flat article. A first transducer assembly is positioned adjacent to a first of the major surfaces of the flat article and a second member is positioned adjacent to a second of the major surfaces. The first transducer assembly generates and transmits acoustical energy to the first major surface of the flat article while the second member either: (1) reflects the acoustical energy generated by the first transducer assembly back to the second major surface of the flat article; and/or (2) generates and transmits acoustical energy to the second major surface of the flat article.

Abstract translation: 用于处理具有声能的扁平制品的系统，装置和方法。 本发明的系统，装置和方法可以更有效和有效地从晶片的两侧去除颗粒。 一方面，本发明是一种用于处理扁平制品的系统和/或方法，其中将液体施加到扁平制品的两个主表面上。 第一换能器组件邻近扁平制品的第一主表面定位，并且第二构件邻近第二主表面定位。 第一传感器组件产生并将声能传递到扁平制品的第一主表面，而第二构件可以：（1）将由第一换能器组件产生的声能反射回平面物品的第二主表面; 和/或（2）产生和传播声能到平坦物品的第二主表面。