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公开(公告)号：US08932600B2
公开(公告)日：2015-01-13
申请号：US13574816
申请日：2011-01-27
CPC分类号： C07K14/35 , A61K39/04 , C07K2319/00
摘要： Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis.
摘要翻译： 改良的Rv3616c蛋白及其用作药物，特别是用于预防结核病的再活化。
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公开(公告)号：US20120294882A1
公开(公告)日：2012-11-22
申请号：US13574816
申请日：2011-01-27
IPC分类号： A61K38/16 , A61P31/06 , C07H21/04 , A61K31/7088 , C07K14/35
CPC分类号： C07K14/35 , A61K39/04 , C07K2319/00
摘要： Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis.
摘要翻译： 改良的Rv3616c蛋白及其用作药物，特别是用于预防结核病的再活化。
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公开(公告)号：US09315556B2
公开(公告)日：2016-04-19
申请号：US13055775
申请日：2009-07-24
申请人： James Brown , Pascal Mettens , Dennis Murphy
发明人： James Brown , Pascal Mettens , Dennis Murphy
CPC分类号： A61K39/04 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , C07H21/04 , C07K14/35 , G01N2333/35 , G01N2800/12
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
摘要翻译： 本发明涉及一种多肽，其包含：（i）Rv1753c蛋白序列; （ii）Rv1753c蛋白序列的变体; 或（iii）Rv1753c蛋白序列的免疫原性片段。 在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。
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公开(公告)号：US20110223200A1
公开(公告)日：2011-09-15
申请号：US13055775
申请日：2009-07-24
申请人： James Brown , Pascal Mettens , Dennis Murphy
发明人： James Brown , Pascal Mettens , Dennis Murphy
CPC分类号： A61K39/04 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , C07H21/04 , C07K14/35 , G01N2333/35 , G01N2800/12
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis
摘要翻译： 本发明涉及一种多肽，其包含：（i）Rv1753c蛋白序列; （ii）Rv1753c蛋白序列的变体; 或（iii）Rv1753c蛋白序列的免疫原性片段。 在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法
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5.发明申请公开(公告)号：US20110206712A1
公开(公告)日：2011-08-25
申请号：US13055787
申请日：2009-07-24
申请人： James Brown , Pascal Mettens , Dennis Murphy
发明人： James Brown , Pascal Mettens , Dennis Murphy
CPC分类号： A61K39/04 , A61K38/00 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , C07K14/35 , C12N9/88 , C12N9/90
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; or (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
摘要翻译： 本发明涉及一种多肽，其包含：（i）Rv2386c蛋白质序列; （ii）Rv2386c蛋白序列的变体; 或（iii）Rv2386c蛋白序列的免疫原性片段。 在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。
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公开(公告)号：US20110117119A1
公开(公告)日：2011-05-19
申请号：US13055801
申请日：2009-07-24
申请人： Pascal Mettens , James Brown , Dennis Murphy
发明人： Pascal Mettens , James Brown , Dennis Murphy
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv3616c protein sequence; (ii) a variant of an Rv3616c protein sequence; or (iii) an immunogenic fragment of an Rv3616c protein sequence for use in the treatment or prevention of latent TB. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of latent tuberculosis.
摘要翻译： 本发明涉及一种多肽，其包含：（i）Rv3616c蛋白序列; （ii）Rv3616c蛋白序列的变体; 或（iii）用于治疗或预防潜伏性TB的Rv3616c蛋白序列的免疫原性片段。 在其它方面，本发明涉及相关的多核苷酸，融合蛋白和用于治疗或预防潜伏性结核病的方法。
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7.发明申请Dendritic-like cell/tumor cell hybrids and hybridomas for inducing an anti-tumor response 审中-公开树突细胞样细胞/肿瘤细胞杂交瘤和诱导抗肿瘤反应的杂交瘤公开(公告)号：US20090081127A1
公开(公告)日：2009-03-26
申请号：US12154939
申请日：2008-05-27
申请人： Muriel Moser , Leo Oberdan , Laurence Lespagnard , Jacques Urbain , Catherine Bruyns , Catherine Gerard , Michel Goldman , Thierry Velu , Fabienne Willems , Nicole Tasiaux , Jason Perret , Anne-Marie Verheyden , Pascal Mettens , Kris Thielemans
发明人： Muriel Moser , Leo Oberdan , Laurence Lespagnard , Jacques Urbain , Catherine Bruyns , Catherine Gerard , Michel Goldman , Thierry Velu , Fabienne Willems , Nicole Tasiaux , Jason Perret , Anne-Marie Verheyden , Pascal Mettens , Kris Thielemans
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , C12N5/16
摘要： The present invention relates to a method of producing a plurality of dendritic cell/tumor cell hybrids which induce an anti-tumor response when applied to a patient. The present invention further relates to a method of producing a dendritic cell/tumor cell hybridoma which induces an anti-tumor response when applied to a patient.
摘要翻译： 本发明涉及当应用于患者时产生多种树突状细胞/肿瘤细胞杂合体的方法，其诱导抗肿瘤反应。 本发明还涉及产生当应用于患者时诱导抗肿瘤反应的树突状细胞/肿瘤细胞杂交瘤的方法。
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8.发明申请Vaccine comprising il-12 or il-23 for treatment of autoimmune diseases 审中-公开包含il-12或il-23的疫苗用于治疗自身免疫性疾病公开(公告)号：US20070048261A1
公开(公告)日：2007-03-01
申请号：US10582810
申请日：2004-12-14
CPC分类号： A61K39/0008 , A61K2039/55555 , A61K2039/55566 , A61K2039/55577
摘要： The present invention provides improved vaccines and immunogenic compositions comprising IL-12 or IL-23, and processes for the preparation of such vaccines and immunogenic compositions.
摘要翻译： 本发明提供改进的疫苗和包含IL-12或IL-23的免疫原性组合物，以及制备这种疫苗和免疫原性组合物的方法。
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公开(公告)号：US20050287137A1
公开(公告)日：2005-12-29
申请号：US11167872
申请日：2005-06-27
申请人： Patrick Dhaese , Pascal Mettens , Rene Meykens , Philippe Monteyne , Torbjorn Schiott , Leif Strandberg
发明人： Patrick Dhaese , Pascal Mettens , Rene Meykens , Philippe Monteyne , Torbjorn Schiott , Leif Strandberg
IPC分类号： A61K39/395 , C07K16/18 , C07K16/44
CPC分类号： C07K16/18 , C07K2317/622
摘要： The present invention relates to novel therapies and treatments of atherosclerotic diseases. Accordingly there is provided, methods of treating or preventing atherosclerosis by passive vaccination through administration to a patient of a fully human antibody that is capable of binding to the specific fragments of ApoCIII. Specific human monoclonal antibodies and their use in therapy of atherosclerosis is provided. There is further provided the use of the antibodies of the present invention in medicine.
摘要翻译： 本发明涉及动脉粥样硬化疾病的新疗法和治疗。 因此，提供了通过向能够结合到ApoCIII的特异性片段的完全人抗体的患者施用被动接种来治疗或预防动脉粥样硬化的方法。 提供特异性人单克隆抗体及其在治疗动脉粥样硬化中的应用。 还提供了本发明的抗体在医药中的用途。
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公开(公告)号：US08541007B2
公开(公告)日：2013-09-24
申请号：US12974428
申请日：2010-12-21
申请人： Mark Alderson , Ajay Bhatia , Yves Lobet , Brenda Maisonneuve , Jean-Francois L Maisonneuve , Martine Marchand , Pascal Mettens , Florence Bernadette Nozay , Peter Probst , Samira H Skeiky
发明人： Mark Alderson , Ajay Bhatia , Yves Lobet , Brenda Maisonneuve , Jean-Francois L Maisonneuve , Martine Marchand , Pascal Mettens , Florence Bernadette Nozay , Peter Probst , Yasir A Skeiky
IPC分类号： A61K39/118
CPC分类号： A61K39/118 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , G01N33/56927
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
摘要翻译： 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。
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