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公开(公告)号：US5384327A
公开(公告)日：1995-01-24
申请号：US994735
申请日：1992-12-22
IPC分类号： A61K31/70 , A61K31/7048 , A61K31/76 , A61P1/06 , A61P13/06 , A61P25/08 , C07D493/04 , C07D493/14 , C07H9/04 , C07H11/00 , C07H13/00 , C07H13/06 , A61K31/35 , C07D311/94
摘要： Sulfamate derivatives having the following formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are as herein defined, have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, the present invention encompasses pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and novel intermediates are disclosed.
摘要翻译： 具有下式（I）的氨基磺酸衍生物：其中R 1，R 2，R 3，R 4，R 5和R 6如本文所定义的其中R 1，R 2，R 3，R 4，R 5和R 6具有抗惊厥活性，因此可用于治疗条件 如癫痫。 此外，本发明包括含有式（I）化合物的药物组合物及其用途及新型中间体。
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公开(公告)号：US4591601A
公开(公告)日：1986-05-27
申请号：US722869
申请日：1985-04-12
IPC分类号： C07D317/18 , A61K31/335 , A61K31/357 , A61P25/08 , A61P27/02 , A61P27/06 , C07D317/24 , C07D317/72 , C07D317/00 , C07D319/00
CPC分类号： C07D317/72 , C07D317/24
摘要： Sulfamates of the following formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention.
摘要翻译： 已发现其中R 1和R 2如本文所定义的下式（I）的磺酰胺具有抗惊厥活性，因此可用于治疗诸如癫痫的病症。 此外，含有式（I）化合物的药物组合物及其用途及中间体构成本发明的一部分。
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公开(公告)号：US4513006A
公开(公告)日：1985-04-23
申请号：US535475
申请日：1983-09-26
IPC分类号： A61F13/02 , A61K31/095 , A61K31/13 , A61K31/135 , A61K31/16 , A61K31/35 , A61K31/351 , A61K31/70 , A61P25/08 , A61P27/02 , A61P27/06 , C07C67/00 , C07C301/00 , C07C305/26 , C07C307/00 , C07C307/02 , C07C325/00 , C07C381/00 , C07D309/04 , C07D309/06 , C07D319/00 , C07D493/00 , C07D493/04 , C07D493/14 , C07H9/04 , C07H11/00 , C07H15/04 , C07D311/78 , C07D311/94
CPC分类号： C07H9/04 , C07D309/06
摘要： Sulfamates of the following formula (I): ##STR1## wherein X is O or CH.sub.2 and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention.
摘要翻译： 下列式（I）的亚磺酰胺：其中X为O或CH 2且R 1，R 2，R 3，R 4和R 5如本文所定义的其中的（I）化合物已被发现具有抗惊厥活性，因此可用于治疗 病情如癫痫。 此外，含有式（I）化合物的药物组合物及其用途及中间体构成本发明的一部分。
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公开(公告)号：US4421917A
公开(公告)日：1983-12-20
申请号：US399029
申请日：1982-07-16
IPC分类号： C07D455/06
CPC分类号： C07D455/06
摘要： 2-Ureido-7-phenylhexahydrobenzo[a]quinolizines of the structural formula, ##STR1## wherein R.sub.1 =H or lower alkyl (one to three carbons) and R.sub.2 =H, lower alkyl (one to six carbons), or phenyl, and which exhibit antihypertensive activity.
摘要翻译： 2-氨基-7-苯基六氢苯并[a]喹嗪衍生物，其中R1 = H或低级烷基（一至三个碳）和R2 = H，低级烷基（一至六个碳），或 苯基，并表现出抗高血压活性。
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公开(公告)号：US08853263B2
公开(公告)日：2014-10-07
申请号：US11750600
申请日：2007-05-18
申请人： Virginia L. Smith-Swintosky , David F. McComsey , Michael H. Parker , Allen B. Reitz , Bruce E. Maryanoff
发明人： Virginia L. Smith-Swintosky , David F. McComsey , Michael H. Parker , Allen B. Reitz , Bruce E. Maryanoff
IPC分类号： C07D311/58 , C07D317/46 , C07D317/70 , C07D319/20 , C07D319/22 , C07D321/10 , A61K31/337 , A61K31/18 , A61K45/06
CPC分类号： A61K31/337 , A61K31/18 , A61K45/06 , C07D311/58 , C07D317/46 , C07D317/70 , C07D319/20 , C07D319/22 , C07D321/10 , A61K2300/00
摘要： The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
摘要翻译： 本发明涉及用于治疗癫痫和相关病症的共同治疗，其包括向有需要的受试者施用治疗有效量的苯并稠合的杂环磺酰胺衍生物和治疗有效量的一种或多种 更多的抗惊厥药和/或抗癫痫剂。
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![Substituted [1,2,3] triazolo[4,5-d]pyrimidine derivatives as ADP P2Y12 receptor antagonists](/abs-image/US/2012/04/03/US08148385B2/abs.jpg.150x150.jpg)
76.发明授权Substituted [1,2,3] triazolo[4,5-d]pyrimidine derivatives as ADP P2Y12 receptor antagonists 有权取代的[1,2,3]三唑并[4,5-d]嘧啶衍生物作为ADP P2Y12受体拮抗剂公开(公告)号：US08148385B2
公开(公告)日：2012-04-03
申请号：US11980907
申请日：2007-10-31
申请人： Han-Cheng Zhang , Bruce E. Maryanoff , Hong Ye , Cailin Chen
发明人： Han-Cheng Zhang , Bruce E. Maryanoff , Hong Ye , Cailin Chen
IPC分类号： C07D487/04 , A61K31/519 , A61P7/02 , A61P9/10 , A61P37/06 , A61P25/06
CPC分类号： C07D487/14
摘要： The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein X1, X2, R1, R2, R3 and R4 are as defined herein, and their methods of preparation and use as ADP inhibitors.
摘要翻译： 本发明涉及式（I）的新型双环三唑并嘧啶化合物或其形式：其中X 1，X 2，R 1，R 2，R 3和R 4如本文所定义，及其制备和用作ADP抑制剂的方法。
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公开(公告)号：US08076294B2
公开(公告)日：2011-12-13
申请号：US12179778
申请日：2008-07-25
申请人： William A. Kinney , Mabel Alarnino Cejas , Bruce E. Maryanoff , Thomas Matalenas , Chunlin Yang
发明人： William A. Kinney , Mabel Alarnino Cejas , Bruce E. Maryanoff , Thomas Matalenas , Chunlin Yang
CPC分类号： C07K14/78 , A61K38/39 , G01N33/86 , G01N2800/224
摘要： The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof.
摘要翻译： 本发明涉及具有能够非共价自组装的N-和C-末端具有疏水性氨基酸基团的胶原相关多肽（CRP），其能够形成胶原模拟三重螺旋和原纤维，并且其合成，使用方法和 的组合物。
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公开(公告)号：US20100240650A1
公开(公告)日：2010-09-23
申请号：US12787034
申请日：2010-05-25
申请人： Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
发明人： Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
IPC分类号： A61K31/5377 , C07D403/04 , A61K31/404 , A61P3/10 , A61P9/00 , A61P29/00 , A61P37/00 , A61P17/00 , A61P27/02 , A61P25/00 , C07D401/14 , A61K31/4439 , C07D403/14 , A61K31/496 , C07D413/14 , A61K31/506 , A61K31/416
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物，用于制备这些化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号：US07786135B2
公开(公告)日：2010-08-31
申请号：US11436000
申请日：2006-05-17
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
IPC分类号： A61K31/437 , A61K31/4353 , A61K31/407
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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公开(公告)号：US07718673B2
公开(公告)日：2010-05-18
申请号：US10345808
申请日：2003-01-16
IPC分类号： A61P9/00 , A61P19/10 , A61K31/445 , C07D211/00 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号： C07D401/04 , C07D211/62 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12
摘要： The invention is directed to novel isonipecotamide derivatives of Formula (I): which are useful in treating integrin-mediated disorders.
摘要翻译： 本发明涉及式（I）的新型异哌耳酰胺衍生物：其可用于治疗整联蛋白介导的病症。
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