公开(公告)号：US06997134B2

公开(公告)日：2006-02-14

申请号：US10359023

申请日：2003-02-05

申请人： Robert Phillip Bayus ,  David Alan Bailey ,  Ramesh M. Gunawardena ,  Michael Miller ,  Harold Eugene Patterson

发明人： Robert Phillip Bayus ,  David Alan Bailey ,  Ramesh M. Gunawardena ,  Michael Miller ,  Harold Eugene Patterson

IPC分类号： B05C19/06

CPC分类号： A23G3/0095 ,  A23G3/0085 ,  A23G3/0089 ,  A23L13/57 ,  A23P20/13

摘要： A drum breader and coating recirculation system that includes a spreader positioned at an end of the drum, the spreader having a plurality of angled surfaces to distribute coatings evenly; a screening platform positioned downstream of the spreader having a drive device for imparting straight-line angular displacement to the screening platform; and a drum feed conveyor positioned downstream of the screening platform, the drum feed conveyor having a belt extending at least partially along an upward angle.

摘要翻译： 鼓面包机和涂层再循环系统，其包括位于滚筒末端的撒布机，撒布机具有多个成角度的表面以均匀地分布涂层; 位于撒布机下游的筛选平台具有用于向筛选平台施加直线角位移的驱动装置; 以及位于所述筛选平台下游的滚筒进料输送机，所述滚筒进料输送机具有至少部分地沿着向上的角度延伸的带。

公开(公告)号：US20060030784A1

公开(公告)日：2006-02-09

申请号：US11247707

申请日：2005-10-11

申请人： Michael Miller ,  Joseph Mark

发明人： Michael Miller ,  Joseph Mark

IPC分类号： A61B10/00

CPC分类号： A61B10/025 ,  A61B10/0283 ,  A61B17/3498 ,  A61B2010/0208 ,  A61B2017/00973 ,  A61B2217/005 ,  A61B2217/007

摘要： A filter element is provided for use with a tissue cutting device. The tissue cutting device includes a tissue collection trap in which the filter element is mounted. The filter element includes a body formed of a mesh material. The mesh material is constructed to allow for fluids to pass through a portion of the filter element while tissue samples excised by the cutting device are retained therein.

摘要翻译： 提供了一种与组织切割​​装置一起使用的过滤元件。 组织切割装置包括其中安装有过滤元件的组织收集阱。 过滤元件包括由网状材料形成的主体。 网状材料被构造成允许流体通过过滤元件的一部分，而由切割装置切除的组织样品保持在其中。

公开(公告)号：US20060025441A1

公开(公告)日：2006-02-02

申请号：US10979075

申请日：2004-11-01

申请人： Michael Miller ,  Jack Scott

发明人： Michael Miller ,  Jack Scott

IPC分类号： A61K31/4545 ,  C07D401/04

CPC分类号： C07D413/14 ,  C07D401/14

摘要： In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

摘要翻译： 在其许多实施方案中，本发明提供了作为CCR5受体的抑制剂的新类型的联哌啶化合物，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物，制备包含一种或多种这样的化合物的药物制剂的方法，以及 使用这些化合物或药物组合物治疗，预防，抑制或改善与CCR5相关的一种或多种疾病的方法。 本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其它药剂的组合的用途。 本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣 ，哮喘，过敏或多发性硬化。

公开(公告)号：US20050270444A1

公开(公告)日：2005-12-08

申请号：US10859314

申请日：2004-06-02

申请人： Michael Miller ,  Michael Murdoch ,  Paul Kane ,  Andrew Arnold ,  Serguei Endrikhovski

发明人： Michael Miller ,  Michael Murdoch ,  Paul Kane ,  Andrew Arnold ,  Serguei Endrikhovski

IPC分类号： G09G3/20 ,  G09G3/32 ,  G09G3/36 ,  G09G5/02 ,  G02F1/1335

CPC分类号： G09G3/3216 ,  G09G3/20 ,  G09G3/3225 ,  G09G3/3607 ,  G09G5/02 ,  G09G2300/0452 ,  G09G2320/02

摘要： A color display device, comprising: an array of subpixels of at least four different colors, including at least two relatively higher luminous color subpixels and at least two relatively lower luminous color subpixels, wherein the subpixels are arranged into groups forming at least two distinct types of pixels, each pixel type including the two relatively higher luminous color subpixels and at least one of the two relatively lower luminous color subpixels, and wherein the pixel types are arranged in a pattern such that the relative locations of the two relatively higher luminous color subpixels in each pixel is repeated in adjacent pixels, and the relative location of at least one of the two relatively lower luminance color subpixels is not repeated in at least one adjacent pixel. Various embodiments of the invention enable color display devices with improved image display quality, with both the appearance of jagged lines and the appearance of banding reduced simultaneously.

摘要翻译： 一种彩色显示装置，包括：至少四种不同颜色的子像素阵列，包括至少两个相对较高的发光子像素和至少两个相对较低的发光颜色子像素，其中子像素被排列成形成至少两种不同类型的组 的像素，每个像素类型包括两个相对较高的发光颜色子像素和两个相对较低的发光颜色子像素中的至少一个，并且其中像素类型被布置成使得两个相对较高的发光颜色子像素的相对位置 在相邻像素中重复每个像素，并且在至少一个相邻像素中不重复两个相对较低亮度的彩色子像素中的至少一个的相对位置。 本发明的各种实施例使得具有改善的图像显示质量的彩色显示设备能够同时缩短锯齿状线条的外观和条纹的外观。

公开(公告)号：US20050234367A1

公开(公告)日：2005-10-20

申请号：US11157569

申请日：2005-06-21

申请人： Michael Miller ,  Dan Ireland

发明人： Michael Miller ,  Dan Ireland

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B17/34 ,  A61B19/00

CPC分类号： A61B10/0275 ,  A61B17/3403 ,  A61B2010/0208 ,  A61B2090/034

摘要： A biopsy instrument for use in a biopsy gun includes a hollow outer needle defining a lumen therethrough and an inner needle slidably engaged within the lumen. The inner needle defines a cavity adjacent its distal end for receiving a tissue sample. A first hub is attached to the proximal end of the inner needle, and a second hub is attached to the proximal end of the outer needle. An elongated pin having a first end and a second end is fixedly attached to the first hub at the first end of the pin. The second end is in sliding contact with the second hub so that the second hub and the pin are slideable relative to each other. A stop engagement is provided between the second end of the pin and the second hub and is configured to prevent disengagement of the outer and inner needles and to maintain a specific physical relationship between the hubs.

摘要翻译： 用于活检枪的活检器械包括限定穿过其中的腔的中空外针和可滑动地接合在内腔内的内针。 内针限定邻近其远端的腔以接收组织样本。 第一轮毂附接到内针的近端，并且第二轮毂连接到外针的近端。 具有第一端和第二端的细长销在销的第一端处固定地附接到第一毂。 第二端与第二轮毂滑动接触，使得第二轮毂和销可相对于彼此滑动。 在销的第二端和第二轮毂​​之间提供止动接合，并且构造成防止外针和内针的分离并且保持轮毂之间的特定物理关系。

公开(公告)号：US20050215939A1

公开(公告)日：2005-09-29

申请号：US11137808

申请日：2005-05-25

申请人： Jessica Lemay ,  Dane Jackson ,  Michael Miller ,  Wayne Melvin

发明人： Jessica Lemay ,  Dane Jackson ,  Michael Miller ,  Wayne Melvin

IPC分类号： A61F13/26 ,  A61F13/20

CPC分类号： A61F13/26 ,  Y10S604/904 ,  Y10T156/10 ,  Y10T156/1038

摘要： There is provided a multiple-component tampon applicator formed from at least three separate components. A fingergrip having a reduced cross-section as compared to that of the barrel may be formed such that it is a separate component or is integrally formed with a barrel component. The reduced cross-section fingergrip provides exceptional grippability to the user. The multiple components may be formed from materials including, for example, biopolymer including starches and proteins, cardboard, heat shrink plastic, paper slurry, plastic, plastic tubing, pulp slurry, pulp-molded paper, or any combinations thereof. Prior to assembly of the applicator and prior to loading the barrel component with an absorbent pledget, petals may be formed on the insertion end of the barrel using existing processes and equipment. Alternatively, a separate insertion tip component having petals may be formed. This separate component may then be connected to the barrel component either before or after an absorbent pledget is loaded into the barrel component.

公开(公告)号：US20050192421A1

公开(公告)日：2005-09-01

申请号：US10789319

申请日：2004-02-27

申请人： Frank Xu ,  Michael Miller ,  Michael Watts

发明人： Frank Xu ,  Michael Miller ,  Michael Watts

IPC分类号： C08L83/04 ,  C08L83/06

CPC分类号： B82Y10/00 ,  B82Y40/00 ,  G03F7/0002

摘要： The present invention includes a composition for a silicon-containing material used as an etch mask for underlying layers. More specifically, the silicon-containing material may be used as an etch mask for a patterned imprinted layer comprising protrusions and recessions. To that end, in one embodiment of the present invention, the composition includes a hydroxyl-functional silicone component, a cross-linking component, a catalyst component, and a solvent. This composition allows the silicon-containing material to selectively etch the protrusions and the segments of the patterned imprinting layer in superimposition therewith, while minimizing the etching of the segments in superposition with the recessions, and therefore allowing an in-situ hardened mask to be created by the silicon-containing material, with the hardened mask and the patterned imprinting layer forming a substantially planarized profile.

摘要翻译： 本发明包括用作下层的蚀刻掩模的含硅材料用组合物。 更具体地，含硅材料可以用作包括突起和凹陷的图案化印记层的蚀刻掩模。 为此，在本发明的一个实施方案中，组合物包括羟基官能的硅氧烷组分，交联组分，催化剂组分和溶剂。 该组合物允许含硅材料与图案化压印层的突起和段的叠加选择性地蚀刻，同时最小化与凹陷叠加的段的蚀刻，并且因此允许形成原位硬化的掩模 通过含硅材料，硬化的掩模和图案化的压印层形成基本平坦化的轮廓。

公开(公告)号：US20050172199A1

公开(公告)日：2005-08-04

申请号：US10772034

申请日：2004-02-03

申请人： Michael Miller ,  Lyman Horne ,  W. Willes ,  Douglas Grover

发明人： Michael Miller ,  Lyman Horne ,  W. Willes ,  Douglas Grover

IPC分类号： G08C25/02 ,  H04L1/08 ,  H04L1/16 ,  H04L1/18

CPC分类号： H04L1/188 ,  H04L1/08 ,  H04L1/16 ,  H04L1/1819

摘要： A data networking system designed to provide efficient yet reliable transportation of data across a time division multiplexed network. This invention allows for redundantly sending and resending of segments in a dynamic manner. In addition, segments are fragmented, resized and sent with low overhead due to dynamic header sizes, segment sizes, forward error correction, and cyclic redundancy checks. The result is a very adaptive network that meets the demanding requirements of networks such as power line and wireless while still being able to transport data for voice, audio, video, computer, control, and the like.

摘要翻译： 一种数据网络系统，旨在通过时分复用网络提供高效可靠的数据传输。 本发明允许以动态方式冗余地发送和重新发送段。 另外，由于动态报头大小，段大小，前向纠错和循环冗余检查，段被分段，调整大小并以低开销发送。 结果是一个非常适合的网络，满足诸如电力线和无线等网络的苛刻要求，同时仍然能够传输语音，音频，视频，计算机，控制等数据。

公开(公告)号：US20050099426A1

公开(公告)日：2005-05-12

申请号：US10703748

申请日：2003-11-07

申请人： Bruno Primerano ,  Michael Miller ,  Michael Murdoch

发明人： Bruno Primerano ,  Michael Miller ,  Michael Murdoch

IPC分类号： G09G3/20 ,  G09G3/32 ,  G09G5/02 ,  H04N1/60

CPC分类号： H04N1/6022 ,  G09G3/20 ,  G09G3/3208 ,  G09G5/02 ,  G09G2300/0452 ,  G09G2320/02

摘要： A method for transforming three color input signals (R, G, B) corresponding to three gamut defining color primaries to four color output signals (R′, G′, B′, W) corresponding to the gamut defining color primaries and one additional color primary W for driving a display having emitters that emit light corresponding to the to the four color output signals including calculating a common signal value S as a function F1 of the three color input signals (R,G,B) for a current and neighboring pixels; determining a final common signal value S′ based upon the common signals for the current and neighboring pixels; calculating the three color signals (R′,G′,B′) by calculating a value of a function F2 of the final common signal value S′ and adding it to each of the three color input signals (R,G,B); and calculating the output signal W as a function F3 of the final common signal value S′.

摘要翻译： 将对应于三个色域定义颜色原色的三色输入信号（R，G，B）变换为与定义颜色原色的色域对应的四色输出信号（R'，G'，B'，W）的一种方法， 用于驱动具有发射与四色输出信号相对应的光的显示器的显示器W，包括计算用于当前和相邻的三色输入信号（R，G，B）的函数F 1的公共信号值S 像素; 基于当前和相邻像素的公共信号确定最终公共信号值S'; 通过计算最终公共信号值S'的函数F 2的值并将其相加到三个颜色输入信号（R，G，B）中的每一个来计算三色信号（R'，G'，B'）， ; 并计算输出信号W作为最终公共信号值S'的函数F 3。

公开(公告)号：US20050085513A1

公开(公告)日：2005-04-21

申请号：US10963711

申请日：2004-10-14

申请人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

发明人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

IPC分类号： A61K31/337 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D305/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  A61K31/4025 ,  A61K31/4433 ,  C07D45/02

CPC分类号： C07D407/12 ,  A61K31/337 ,  C07D305/14 ,  C07D407/14 ,  C07D409/12 ,  Y02A50/423 ,  Y02A50/491

摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a link, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

摘要翻译： 包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒性量的一种或多种通过连接体与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂 。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。