利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

154 条记录 (耗时 0.065 秒)

    Methods of using cytokine receptor zalpha11 to detect its ligands
    76.
    发明授权
    Methods of using cytokine receptor zalpha11 to detect its ligands 有权
    使用细胞因子受体zalpha11检测其配体的方法

    公开(公告)号：US06692924B2

    公开(公告)日：2004-02-17

    申请号：US10414186

    申请日：2003-04-14

    申请人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    发明人： Scott R. Presnell ,  Darrell C. Conklin ,  Julia E. Novak ,  Angela K. Hammond

    IPC分类号： G01N3353

    CPC分类号： C07H21/04 ,  C07K14/715 ,  C07K16/1232 ,  C07K16/2866 ,  C07K2317/32 ,  C07K2319/00

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。