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    Treatment using antibodies to cytokine receptor common gamma chain like
    72.
    发明授权
    Treatment using antibodies to cytokine receptor common gamma chain like 有权
    治疗使用细胞因子受体常见γ链的抗体

    公开(公告)号：US07504105B2

    公开(公告)日：2009-03-17

    申请号：US10899107

    申请日：2004-07-27

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

    IPC分类号： A61K39/00 ,  C07K16/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7155

    摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.

    摘要翻译： 本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。 更具体地，本发明涉及一种编码新型人多肽的多核苷酸，命名为“细胞因子受体共同伽马链样”或“CRCGCL”。 本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体及其制备方法。 还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。 本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。

    Peptidoglycan recognition proteins
    74.
    发明授权
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US07368244B2

    公开(公告)日：2008-05-06

    申请号：US11214796

    申请日：2005-08-31

    申请人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07H21/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    Peptidoglycan recognition proteins
    75.
    发明授权
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US07041802B2

    公开(公告)日：2006-05-09

    申请号：US10180454

    申请日：2002-06-27

    申请人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C12N5/06 ,  G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    Peptidoglycan recognition proteins
    76.
    发明授权
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US06444790B1

    公开(公告)日：2002-09-03

    申请号：US09469242

    申请日：1999-12-22

    申请人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07K100

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    G-protein parathyroid hormone receptor HLTDG74
    77.
    发明授权
    G-protein parathyroid hormone receptor HLTDG74 失效

    公开(公告)号：US06338951B1

    公开(公告)日：2002-01-15

    申请号：US09236468

    申请日：1999-01-25

    申请人： Daniel Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K1472

    CPC分类号： C07K14/723 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    Polynucleotides encoding human tumor necrosis factor receptor-like2
    78.
    发明授权
    Polynucleotides encoding human tumor necrosis factor receptor-like2 失效
    编码人肿瘤坏死因子受体的多核苷酸2

    公开(公告)号：US07427492B1

    公开(公告)日：2008-09-23

    申请号：US08741095

    申请日：1996-10-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N15/64 ,  C12N15/09 ,  C12N5/16 ,  C12N5/10 ,  C12N1/11 ,  C12N1/15 ,  C12N1/21

    CPC分类号： C07K14/7151

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    Death domain containing receptor-4 antibodies
    80.
    发明授权
    Death domain containing receptor-4 antibodies 有权
    含有受体-4抗体的死亡域

    公开(公告)号：US06461823B1

    公开(公告)日：2002-10-08

    申请号：US09448868

    申请日：1999-11-24

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： G01N33567

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法。