摘要:
This invention relates to compounds of the formula wherein one of R6, R7 or R8 is and all enantiomers and pharmaceutically acceptable salts and/or esters thereof as well as pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要:
A variable valve gear for internal combustion engines, having at least one camshaft and pivot lever disposed in the cylinder head, which lever contacts a valve that closes by means of spring force. An intermediate element of a transfer element is mounted in a supporting and displaceable manner, twice on the supporting body and on the pivot lever. The intermediate element engages a supporting surface disposed on the supporting body, first by way of a supporting cam segment disposed on the intermediate element, and second with the controlling cam segment of the supporting body, and third with the pivot lever, by way of an outer contour surface disposed on the intermediate element. The intermediate element indirectly contacts the cam of the camshaft, by way of a roller disposed on an oscillating crank, which is connected with the intermediate element in articulated manner.
摘要:
The present invention relates to compounds of formula (I) wherein R1 to R8 and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.
摘要:
The present invention provides compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4, A and n have the significance given in the specification. The compounds or their salts may be administered to a patient for treating non-insulin dependent diabetes mellitus.
摘要:
The invention relates to the polypeptide COM and its derivatives, and methods for its preparation and recovery in a pure or partially purified form from body fluids and tissues, and its use as a medicament.
摘要:
A method and a device for the production of coloured animal or human foodstuffs and corresponding device, in particular, animal or human foodstuffs with two colours having clearly defined coloured regions. The above is achieved, whereby a product stream, preferably produced in an extruder, is divided into several independent part streams (depending on the number of colours) in a mixing run and each partial stream is mixed with a colour in a mixing chamber. The partial streams are mixed just before outlet nozzles on a nozzle plate, such that end products with clearly defined colour regions are produced after expansion and cutting.
摘要:
The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPARα and/or PPARγ agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.
摘要:
This invention relates to compounds of the formula I: wherein one of R6, R7 and R8 is and R1 to R15 and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR δ and/or PPARα agonists.
摘要翻译:本发明涉及式I化合物:其中R 6,R 7和R 8中的一个是R 1和R 2, R 15和R 15如在说明书中所定义,以及所有对映异构体及其药学上可接受的盐和/或酯。 本发明还涉及含有这些化合物的药物组合物,其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。
摘要:
There are presented compounds of the formula wherein R6 and R7 is R4 and R5 or R5 and R6 together with the carbon atoms to which they are attached, form a ring as defined in the description and X1, X2, Y1 to Y4, R1 to R13 and n are as specified in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.