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114 条记录 (耗时 0.058 秒)

    Tri-, tetra-substituted-3-aminopyrrolidine derivative
    71.
    发明授权
    Tri-, tetra-substituted-3-aminopyrrolidine derivative 有权
    三取代的3-氨基吡咯烷衍生物

    公开(公告)号：US07563805B2

    公开(公告)日：2009-07-21

    申请号：US11413153

    申请日：2006-04-28

    申请人： Hisashi Takahashi ,  Hiroaki Inagaki ,  Satoshi Komoriya ,  Makoto Takemura ,  Rie Miyauchi

    发明人： Hisashi Takahashi ,  Hiroaki Inagaki ,  Satoshi Komoriya ,  Makoto Takemura ,  Rie Miyauchi

    IPC分类号： A01N43/42 ,  A61K31/47 ,  C07D215/00

    CPC分类号： C07D207/14 ,  Y02P20/55

    摘要： A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria, and which are also highly safe are provided. The compound provided is represented by following formula (I): wherein R1 and R2 represent hydrogen atom, or the like; R3 represents an alkyl group containing 1 to 6 carbon atoms, or the like; R4 and R5 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like, with the proviso that R4 and R5 do not simultaneously represent hydrogen atom; or the substituents R4 and R5 together represent (a) a 3- to 6-membered cyclic structure including the carbon atom shared by R4 and R5 to form a spirocyclic structure with the pyrrolidine ring; R6 and R7 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like; R8 represents a halogen-substituted alkyl group containing 1 to 6 carbon atoms, or the like; X1 represents hydrogen atom or a halogen atom; A represents nitrogen atom or a moiety represented by formula (II):

    摘要翻译： 提供喹诺酮合成抗菌剂和用于感染的治疗剂，其对革兰氏阳性和革兰氏阴性细菌都具有广谱和强抗菌活性，并且也是高度安全的。 所提供的化合物由下式（I）表示：其中R1和R2表示氢原子等; R3表示含有1〜6个碳原子的烷基等; R4和R5独立地表示氢原子，含有1至6个碳原子的烷基等，条件是R4和R5不同时表示氢原子; 取代基R 4和R 5一起表示（a）包含由R 4和R 5共有的碳原子与吡咯烷环形成螺环结构的3至6元环状结构; R6和R7独立地表示氢原子，含有1至6个碳原子的烷基等; R8表示含有1〜6个碳原子的卤素取代的烷基等; X1表示氢原子或卤素原子; A表示氮原子或由式（II）表示的部分：

    Aminomethylpyrrolidine derivatives having aromatic substituents
    72.
    发明授权
    Aminomethylpyrrolidine derivatives having aromatic substituents 失效

    公开(公告)号：US07186843B2

    公开(公告)日：2007-03-06

    申请号：US10834079

    申请日：2004-04-29

    申请人： Makoto Takemura ,  Hisashi Takahashi ,  Katsuhiro Kawakami ,  Toshiyuki Takeda ,  Rie Miyauchi

    发明人： Makoto Takemura ,  Hisashi Takahashi ,  Katsuhiro Kawakami ,  Toshiyuki Takeda ,  Rie Miyauchi

    IPC分类号： C07D207/09 ,  C07D401/12 ,  C07D403/12

    CPC分类号： C07D401/04 ,  C07D405/14

    摘要： This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of the same or a hydrate of both. In the formula, R2, R3: hydrogen atom, an alkyl group; R4, R5, R6: hydrogen atom, hydroxyl group, a halogen atom, carbamoyl group, an alkyl group, an alkoxyl group, an alkylthio group; R7, R8: hydrogen atom, an alkyl group; R9: an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, an aryl group, a heteroaryl group, an alkoxyl group having from 1 to 6 carbon atoms, an alkylamino group; R10:hydrogen atom, an alkylthio group; R11: hydrogen atom, amino group, hydroxyl group, thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; X1: halogen atom, a hydrogen atom; A1: nitrogen atom, C—X2; X2: hydrogen atom, amino group, a halogen atom, cyano group, an halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; A2, A3:>C═C (—A1═)—N(—R9)—, >N—C (—A1>)═C(—R9)—; R10 and R9 or R9 and X2 may be integrated to form a ring structure; and Y: hydrogen atom, ester forming group.

    Integrated high voltage capacitor having capacitance uniformity structures and a method of manufacture therefor
    74.
    发明申请
    Integrated high voltage capacitor having capacitance uniformity structures and a method of manufacture therefor 有权
    具有电容均匀结构的集成高压电容器及其制造方法

    公开(公告)号：US20060189089A1

    公开(公告)日：2006-08-24

    申请号：US11250047

    申请日：2005-10-13

    申请人： David Larkin ,  Lily Springer ,  Makoto Takemura ,  Ashish Gokhale ,  Dhaval Saraiya

    发明人： David Larkin ,  Lily Springer ,  Makoto Takemura ,  Ashish Gokhale ,  Dhaval Saraiya

    IPC分类号： H02M3/335 ,  H01L21/20 ,  H01L29/00

    CPC分类号： H01L27/0688 ,  H01L23/5223 ,  H01L2924/0002 ,  H01L2924/00

    摘要： The present invention provides an integrated high voltage capacitor, a method of manufacture therefore, and an integrated circuit chip including the same. The integrated high voltage capacitor, among other features, includes a first capacitor plate (120) located over or in a semiconductor substrate (105), and an insulator (130) located over the first capacitor plate (120), at least a portion of the insulator (130) comprising an interlevel dielectric layer (135, 138, 143, or 148). The integrated high voltage capacitor further includes capacitance uniformity structures (910) located at least partially within the insulator (130) and a second capacitor plate (160) located over the insulator (130).

    摘要翻译： 本发明提供一种集成的高压电容器，因此制造方法以及包括该高压电容器的集成电路芯片。 集成的高压电容器以及其它特征包括位于半导体衬底（105）上方或半导体衬底（105）中的第一电容器板（120）和位于第一电容器板（120）上方的绝缘体（130），至少一部分 所述绝缘体（130）包括层间介电层（135,138,143或148）。 集成高压电容器还包括至少部分位于绝缘体（130）内的电容均匀性结构（910）和位于绝缘体（130）上方的第二电容器板（160）。

    Aminomethylpyrrolidine derivatives having aromatic substituents
    75.
    发明授权
    Aminomethylpyrrolidine derivatives having aromatic substituents 失效
    具有芳香取代基的氨基甲基吡咯烷衍生物

    公开(公告)号：US06762181B1

    公开(公告)日：2004-07-13

    申请号：US09936050

    申请日：2001-09-07

    申请人： Makoto Takemura ,  Hisashi Takahashi ,  Katsuhiro Kawakami ,  Toshiyuki Takeda ,  Rie Miyauchi

    发明人： Makoto Takemura ,  Hisashi Takahashi ,  Katsuhiro Kawakami ,  Toshiyuki Takeda ,  Rie Miyauchi

    IPC分类号： A61K314375

    CPC分类号： C07D401/04 ,  C07D405/14

    摘要： This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of the same or a hydrate of both. In the formula, R2, R3: hydrogen atom, an alkyl group; R4, R5, R6: hydrogen atoms, hydroxyl group, a halogen atom, carbamoyl group, an alkyl group, an alkoxyl group, an alkylthio group; R7, R8: hydrogen atom, an alkyl group; R9: an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, an aryl group, a heteroaryl group, an alkoxyl group having from 1 to 6 carbon atoms, an alkylamino group; R10: hydrogen atom, an alkylthio group; R11: hydrogen atom, amino group, hydroxyl group, thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; X1: halogen atom, a hydrogen atom; A1: nitrogen atom, C—X2; X2: hydrogen atom, amino group, a halogen atom, cyano group, an halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; A2, A3: >C═C(—A1═)—N(—R9)—, >N—C(—A1═)═C(—R9)—; R10 and R9 or R9 and X2 may be integrated to form a ring structure; and Y: hydrogen atom, ester forming group.

    摘要翻译： 本发明提供了一种喹诺酮衍生物，其具有对各种细菌的抗菌活性，包括耐药菌株，其为下式的化合物，其中R 1为任选取代的芳族基团，其两者的盐或两者的水合物。 式R 2，R 3：氢原子，烷基; R 4，R 5，R 6：氢原子，羟基，卤素原子，氨基甲酰基，烷基，烷氧基，烷硫基; R 7，R 8：氢原子，烷基; R 9：烷基，烯基，卤代烷基，环状烷基，芳基，杂芳基，碳原子数1〜6的烷氧基，烷基氨基， R 10：氢原子，烷硫基; R 11：氢原子，氨基，羟基，硫醇基，卤代甲基，烷基，烯基，炔基，烷氧基; X 1：卤素原子，氢原子; A 1：氮原子，C-X 2; X 2：氢原子，氨基，卤原子，氰基，卤代甲基，卤代甲氧基，烷基，烯基，炔基，烷氧基; A 2，A 3：C = C（-A 1 =）-N（-R 9） - ，> NC（-A 1）= C（-R 9） >） - ; R 10和R 9或R 9和X 2可以一体形成环结构; 和Y：氢原子，酯形成基团。

    Heterocyclic spiro-derivative
    76.
    发明授权
    Heterocyclic spiro-derivative 失效
    杂环螺衍生物

    公开(公告)号：US06469023B1

    公开(公告)日：2002-10-22

    申请号：US08875863

    申请日：1997-08-07

    申请人： Makoto Takemura ,  Youichi Kimura ,  Hitoshi Ohki

    发明人： Makoto Takemura ,  Youichi Kimura ,  Hitoshi Ohki

    IPC分类号： A61K3144

    CPC分类号： C07D401/04

    摘要： The present invention provides an antibacterial compound useful as medicines, animal drugs, fisheries drugs or antibacterial preservatives and to an antibacterial agent or preparation which contains the same, more particularly a compound which possesses high safety and excellent activity against a broad range of bacterial species including quinolone-resistant strains. A quinolone derivative of the following formula (I) which has a group derived from the heterocyclic spiro-compound at the 7-positioned R2 and the halogenocyclopropyl group at the N1-position, prefereably a compound of pure isomer, and an antibacterial agent containing the derivative compound.

    摘要翻译： 本发明提供了可用作药物，动物药物，渔业药物或抗菌防腐剂的抗菌化合物，以及含有该抗菌剂或抗菌剂的抗菌剂或制剂，更具体地，涉及对广泛的细菌种类具有高安全性和优异活性的化合物，包括 喹诺酮耐药株。 下述式（I）的喹啉酮衍生物，其具有衍生自7-位R2上的杂环螺环化合物和N1位上的卤代环丙基的基团，优选纯异构体的化合物和含有 衍生化合物。

    Cycloalkylaminomethylpyrrolidine derivatives
    78.
    发明授权
    Cycloalkylaminomethylpyrrolidine derivatives 失效
    环烷基氨基甲基吡咯烷衍生物

    公开(公告)号：US06194434B1

    公开(公告)日：2001-02-27

    申请号：US09171637

    申请日：1998-10-22

    申请人： Makoto Takemura ,  Youichi Kimura ,  Katsuhiro Kawakami ,  Hitoshi Ohki

    发明人： Makoto Takemura ,  Youichi Kimura ,  Katsuhiro Kawakami ,  Hitoshi Ohki

    IPC分类号： A61K3147

    CPC分类号： C07D401/04

    摘要： A quinolone derivative represented by formula (I): wherein R1 represents a cycloalkyl group; R2 represents a hydrogen atom, an amino group, a hydroxyl group, a thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R3 represents an amino group, a halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R5 represents a cycloalkyl group having 3 to 6 carbon atoms; the above R1 to R5 may be substituted; X represents a halogen atom or a hydrogen atom; and Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms, or a phenylalkyl group having 1 to 6 carbon atoms in the alkyl moiety thereof, or a salt thereof. The compound exhibits high and broad antimicrobial activity against various bacteria including bacteria resistant to drugs and high safety.

    摘要翻译： 由式（I）表示的喹诺酮衍生物：其中R1表示环烷基; R2表示氢原子，氨基，羟基，硫醇基，卤代甲基，烷基，烯基，炔基或烷氧基; R3表示氨基，卤代甲基，卤代甲氧基，烷基，烯基，炔基或烷氧基; R4表示氢原子或碳原子数1〜6的烷基。 R5表示碳原子数3〜6的环烷基; 上述R 1〜R 5可以被取代; X表示卤素原子或氢原子; Y表示氢原子，苯基，乙酰氧基甲基，新戊酰氧基甲基，乙氧基羰基，胆碱基，二甲基氨基乙基，5-二氢化茚基，苯酞基，5-烷基-2-氧代 - 1,3-二氧杂环戊烯-4-基甲基，3-乙酰氧基-2-氧代丁基，碳原子数1〜6的烷基，碳原子数2〜7的烷氧基甲基或碳原子数1〜6的苯基烷基 其烷基部分的原子，或其盐。 该化合物对各种细菌（包括对药物有抗性的细菌和高安全性）具有高而广的抗菌活性。

    Recording apparatus and method for forming plural dots in a pixel
    79.
    发明授权
    Recording apparatus and method for forming plural dots in a pixel 失效
    用于在像素中形成多个点的记录装置和方法

    公开(公告)号：US06106100A

    公开(公告)日：2000-08-22

    申请号：US453577

    申请日：1995-05-26

    申请人： Koji Terasawa ,  Makoto Takemura ,  Katsuyuki Yokoi

    发明人： Koji Terasawa ,  Makoto Takemura ,  Katsuyuki Yokoi

    IPC分类号： H04N1/405 ,  H04N1/52 ,  B41J2/145

    CPC分类号： H04N1/52 ,  H04N1/4051

    摘要： There is disclosed a dot forming method and a recording apparatus, suitable for unprocessed recording medium, such as plain paper having fluctuation in its ink absorbing ability, or a plastic sheet with low ink absorbing ability. At the formation of each pixel with plural dots, the dots are so distributed that they are not continuous but are mutually complementary in the transverse and longitudinal directions of the pixel and also at least in the boundary area of adjacent pixels.

    摘要翻译： 公开了适用于未加工的记录介质的点形成方法和记录装置，例如其吸墨能力波动的普通纸或具有低吸墨能力的塑料片。 在形成具有多个点的每个像素时，这些点是分布的，使得它们不是连续的，而是在像素的横向和纵向方向以及至少在相邻像素的边界区域中互补。