公开(公告)号：US06664411B2

公开(公告)日：2003-12-16

申请号：US09818339

申请日：2001-03-27

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

IPC分类号： C07C6976

CPC分类号： C07C323/62 ,  C07C235/48 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereosomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, novel intermediates and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的盐 本发明还涉及制备上述新化合物，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂合物的方法 ，新颖的中间体和含有它们的药物组合物。

公开(公告)号：US5925656A

公开(公告)日：1999-07-20

申请号：US621226

申请日：1996-03-25

申请人： Anji Reddy Kallam ,  Vidya Bhushan Lohray ,  Sekhar Reddy Alla ,  Harikishore Pingali ,  Rajagopalan Ramanujam ,  Seshagiri Rao Casturi

发明人： Anji Reddy Kallam ,  Vidya Bhushan Lohray ,  Sekhar Reddy Alla ,  Harikishore Pingali ,  Rajagopalan Ramanujam ,  Seshagiri Rao Casturi

IPC分类号： C07D277/34 ,  C07D417/12 ,  A61K31/425

CPC分类号： C07D417/12 ,  C07D277/34

摘要： Thiazolidinediones of formula (I) their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them having antidiabetic, hypolipidemic, and antihypertensive properties have been prepared. ##STR1##

摘要翻译： 已经制备了式（I）的噻唑烷二酮，其互变异构形式，其衍生物，其立体异构体，它们的多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药物组合物，其具有抗糖尿病，降血脂症和抗高血压性质。

公开(公告)号：US20100048550A1

公开(公告)日：2010-02-25

申请号：US12446820

申请日：2007-10-15

申请人： Saurin Raval ,  Preeti Raval ,  Braj Lohray ,  Vidya Bhushan Lohray ,  Pankaj R. Patel

发明人： Saurin Raval ,  Preeti Raval ,  Braj Lohray ,  Vidya Bhushan Lohray ,  Pankaj R. Patel

IPC分类号： A61K31/5375 ,  C07C229/40 ,  A61K31/195 ,  C07D211/40 ,  A61K31/445 ,  C07D241/04 ,  A61K31/495 ,  C07D295/08 ,  A61P3/06 ,  A61K31/24 ,  A61P3/04

CPC分类号： C07C271/28 ,  C07C229/18 ,  C07C229/24 ,  C07C235/46 ,  C07C235/54 ,  C07C311/16 ,  C07C311/20 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/42 ,  C07D295/192 ,  C07D295/26 ,  C07D333/28

摘要： The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta(TR-Beta). Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及作为甲状腺受体配体并且优选甲状腺激素受体β（TR-β）选择性的通式（I）的新型化合物。 此外，本发明涉及制备这些化合物的方法，它们的互变异构形式，涉及其合成的新中间体，其药学上可接受的盐，使用这些化合物的方法和含有它们的药物组合物。