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    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS
    74.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS 审中-公开

    公开(公告)号：US20170270268A1

    公开(公告)日：2017-09-21

    申请号：US15606743

    申请日：2017-05-26

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid

    IPC: G06F19/00 ,  G06F19/28

    Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    METHOD AND SYSTEM FOR CHARACTERIZING SKIN RELATED CONDITIONS
    76.
    发明申请
    METHOD AND SYSTEM FOR CHARACTERIZING SKIN RELATED CONDITIONS 审中-公开

    公开(公告)号：US20170228514A1

    公开(公告)日：2017-08-10

    申请号：US15497072

    申请日：2017-04-25

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Jessica Richman ,  Catalina Valdivia ,  Daniel Almonacid

    IPC: G06F19/00 ,  G06F19/28 ,  C12Q1/68 ,  G06F19/24

    CPC classification number: G06F19/3418 ,  C12Q1/6874 ,  G06F19/00 ,  G06F19/24 ,  G06F19/28 ,  G16H50/20 ,  Y02A90/26

    Abstract: Embodiments of a method and system for characterizing a skin-related condition in relation to a user can include one or more of: a handling network operable to collect containers comprising material from a set of users, the handling network comprising a sequencing system operable to determine microorganism sequences from sequencing the material; a microbiome characterization system operable to: determine at least one of microbiome composition data and microbiome functional diversity data based on the microorganism sequences, collect supplementary data associated with the skin-related condition for the set of users, and transform the supplementary data and the at least one of the microbiome composition data and the microbiome functional diversity data into a characterization model; and a therapy system operable to promote a treatment to the user for the skin-related condition based on characterizing the user with the characterization model in relation to the skin-related condition.

    DIGITAL MICROFLUIDICS SYSTEM AND METHOD
    78.
    发明申请
    DIGITAL MICROFLUIDICS SYSTEM AND METHOD 审中-公开
    数字微流体系统与方法

    公开(公告)号：US20170038368A1

    公开(公告)日：2017-02-09

    申请号：US15228890

    申请日：2016-08-04

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Nathan Saichek ,  Jessica Richman

    IPC: G01N33/543 ,  G01N27/447 ,  C12Q1/68 ,  B01L3/00 ,  C12N15/10

    CPC classification number: G01N33/5438 ,  B01L3/502707 ,  B01L3/502792 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1827 ,  B01L2400/0427 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/54326

    Abstract: A system and method for sample droplet processing, the system including a substrate, an electrode array network coupled to the substrate and configured to provide a pattern of controlled electric fields for manipulation of the set of sample droplets; a first layer in communication with the electrode array network, the first layer separating the electrode array network from fluid of the set of sample droplets; and a second layer opposing the first layer and displaced from the first layer to define a region wherein droplets of the set of sample droplets can reside. In some variations, the system can additionally include an electronics subsystem coupled to at least one of the substrate and the electrode array network, and a control module in communication with the electronics subsystem, wherein the control module generates and manipulates the pattern of controlled electric fields.

    Abstract translation: 一种用于样本液滴处理的系统和方法，所述系统包括基板，耦合到所述基板的电极阵列网络，并且被配置为提供用于操纵所述一组样品液滴的受控电场的图案; 与所述电极阵列网络连通的第一层，所述第一层将所述电极阵列网与所述一组样品液滴的流体分离; 以及与所述第一层相对并且从所述第一层移位的第二层，以限定所述一组样品液滴的液滴可以驻留的区域。 在一些变型中，该系统还可以包括耦合到衬底和电极阵列网络中的至少一个的电子子系统以及与电子子系统通信的控制模块，其中控制模块产生并操纵受控电场的模式 。

    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR LOCOMOTOR SYSTEM CONDITIONS
    79.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR LOCOMOTOR SYSTEM CONDITIONS 审中-公开
    用于定位系统条件的微生物衍生诊断和治疗方法和系统

    公开(公告)号：US20160259909A1

    公开(公告)日：2016-09-08

    申请号：US15098222

    申请日：2016-04-13

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

    IPC: G06F19/00 ,  G06F19/12

    CPC classification number: G06F19/3418 ,  G16B20/00 ,  G16B50/00 ,  G16H20/00 ,  G16H50/50 ,  Y02A50/57 ,  Y02A90/26

    Abstract: A method for at least one of characterizing, diagnosing, and treating a locomotor system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the locomotor system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the locomotor system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗运动系统状况的方法，所述方法包括：从受试者群体接收聚集的一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征，产生运动系统状况的表征; 基于所述表征，产生被配置为校正所述运动系统状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。

    METHOD AND SYSTEM FOR MICROBIOME-DERIVED CHARACTERIZATION, DIAGNOSTICS AND THERAPEUTICS FOR CONDITIONS ASSOCIATED WITH FUNCTIONAL FEATURES
    80.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED CHARACTERIZATION, DIAGNOSTICS AND THERAPEUTICS FOR CONDITIONS ASSOCIATED WITH FUNCTIONAL FEATURES 审中-公开
    用于与功能特征相关的条件的微生物衍生特征，诊断和治疗方法和系统

    公开(公告)号：US20160228003A1

    公开(公告)日：2016-08-11

    申请号：US15098110

    申请日：2016-04-13

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

    IPC: A61B5/00 ,  G06F19/00 ,  C12Q1/68 ,  G06F19/12 ,  G06F19/28

    CPC classification number: A61B5/0022 ,  A61B5/4836 ,  C12Q1/689 ,  C12Q2600/112 ,  G06F19/3418 ,  G16B40/00 ,  G16B50/00 ,  G16H40/67 ,  G16H50/20 ,  G16H50/80 ,  Y02A90/24 ,  Y02A90/26

    Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome-derived functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    Abstract translation: 用于至少一种表征，诊断和治疗与至少一个受试者中的产生微生物体的功能特征相关的病症的方法，所述方法包括：从受试者群体接收聚集的一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集中提取的特征产生条件的表征; 基于所述表征，产生被配置为校正所述状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。

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