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公开(公告)号：US11612620B2
公开(公告)日：2023-03-28
申请号：US16633618
申请日：2018-06-21
发明人： Sung Won Kim , Seung Ki Kwok , Jaeseon Lee , Sun hwa Park , Jung Yeon Lim
摘要： The present invention relates to a pharmaceutical composition for preventing or treating rheumatoid arthritis, and a stem cell therapeutic agent for treating rheumatoid arthritis, comprising nasal inferior turbinate-derived mesenchymal stem cells as an active ingredient. Nasal inferior turbinate-derived mesenchymal stem cells of the present invention have the effects of reducing the production of interleukin-17A (IL-17A), tumor necrosis factor-α (TNF-α), immunoglobulin G2 (IgG2a) which is an inflammation-inducing factor, and/or the proliferative ability of lymph node T cells, increasing interleukin-10 (IL-10) and/or regulatory T-cells (Treg, CD4+CD25+foxp3+ cell) that contribute to immune tolerance in spleen cells, and inhibiting the proliferation of human T-cells. The nasal inferior turbinate-derived mesenchymal stem cells have a safer acquisition process than existing mesenchymal stem cells and can be acquired in sufficient amounts within a desired period of time, thus allowing mesenchymal stem cells to be acquired at low cost and high efficiency. Moreover, since the nasal inferior turbinate-derived mesenchymal stem cells have the same genetic origin as individuals administered therewith there are few side effects, the nasal inferior turbinate-derived mesenchymal stem cells can be usefully used for preventing or treating in individually tailored immunocompatible rheumatoid arthritis.
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公开(公告)号：US11597705B2
公开(公告)日：2023-03-07
申请号：US17568840
申请日：2022-01-05
发明人： Dong Wook Kang , Jong Yun Jang , Seong Jeong Lee , Jeong In Kim , Ju Yeon Bae , Hyeon Ho Jeon , Hee Yoon Ryu
IPC分类号： C07D257/04
摘要： The present invention provides a method for producing high-purity 5-methyl-1H-tetrazole in high yield.
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公开(公告)号：US11591305B2
公开(公告)日：2023-02-28
申请号：US17570420
申请日：2022-01-07
发明人： Dong Wook Kang , Min Gi Chu , Seok Ju Lee , Eun Jung Lee
IPC分类号： C07D311/32
摘要： The present invention provides a method for producing fisetin or fisetin derivatives, which is capable of mass production. The method for producing fisetin or fisetin derivatives according to the present invention is capable of mass-producing fisetin or fisetin derivatives without a purification process such as a column chromatography process.
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公开(公告)号：US20220220086A1
公开(公告)日：2022-07-14
申请号：US17568840
申请日：2022-01-05
发明人： Dong Wook KANG , Jong Yun JANG , Seong Jeong LEE , Jeong In KIM , Ju Yeon BAE , Hyeon Ho JEON , Hee Yoon RYU
IPC分类号： C07D257/04
摘要： The present invention provides a method for producing high-purity 5-methyl-1H-tetrazole in high yield.
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公开(公告)号：US20210347639A1
公开(公告)日：2021-11-11
申请号：US17274539
申请日：2019-09-04
发明人： Sang Ryul LEE , Kyoung Chol KIM , Ja Young PARK , Ji Hyeong KIM , Jeong In KIM , Seok Ju LEE , Jongyun JANG , Seongjeong LEE , Mingi CHU , Dong Wook KANG
IPC分类号： C01B21/086
摘要： A method for producing a bis(fluorosulfonyl)imide lithium salt is disclosed. The method includes the steps of: (a) reacting bis(chlorosulfonyl)imide with NH4F(HF)n (n=0-10) to prepare ammonium bis(fluorosulfonyl)imide; and (b) reacting the ammonium bis(fluorosulfonyl)imide with a lithium base, wherein in at least one of steps (a) and (b), after the reaction, a process of adding an alkoxy trialkyl silane to the reaction solution to remove a fluorine anion is performed.
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公开(公告)号：US10792309B2
公开(公告)日：2020-10-06
申请号：US13966153
申请日：2013-08-13
发明人： Mi La Cho , Seok-Goo Cho , Jung-Yeon Lim , Hyun-Sil Park , Min-Jung Park
IPC分类号： C07K14/715 , A61K35/28 , C12N5/0783 , C12N5/0775 , A61K31/21 , A61K39/00 , A61K35/17
摘要： The present invention relates to a cell therapy composition for preventing or treating immune disease comprising mesenchymal stem cells and immunoregulatory T-cells as an active ingredient. By infusing mesenchymal stem cells and immunoregulatory T-cells, which are the cellular therapeutic agent of the present invention, into bone marrow transplant animals, rejection to the host is suppressed after the engraftment of the transplanted bone-marrow to thus obtain the effect of reducing graft-versus-host disease and immune disease. Moreover, the effect of such GVHD reduction is much greater than the one obtained when only mesenchymal stem cells are infused. Accordingly, the cell therapy composition of the present invention having the above-mentioned effects can be useful in the prevention or treatment of immune disease.
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77.发明授权公开(公告)号：US10076572B2
公开(公告)日：2018-09-18
申请号：US14690293
申请日：2015-04-17
发明人： Hiun Suk Chae , Sung Sook Choi
IPC分类号： A61K41/00 , A61N5/06 , A61K31/65 , A61K31/722
CPC分类号： A61K41/0057 , A61K31/65 , A61K31/722 , A61N5/062 , A61N5/0624 , A61N2005/0661
摘要： Effective Photodynamic therapy (PDT) against C. difficile is provided using a composition including chitosan and tetracycline.
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公开(公告)号：US20180221343A1
公开(公告)日：2018-08-09
申请号：US15941856
申请日：2018-03-30
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
发明人： Kyu-Yang YI , Sung-Eun YOO , Nack-Jeong KIM , Jee-Hee SUH , Choun-Ki JOO , Jun-Sub CHOI , Jae-Sik YANG , Geun-Hyeog LEE , Yun-Seok CHO , Jin-Ha PARK , Hye-Sung LEE
IPC分类号： A61K31/4178 , A61P27/02 , A61K9/00 , A61K9/08
CPC分类号： A61K31/4178 , A61K9/0048 , A61K9/08 , A61K9/10 , A61K47/10 , A61K47/32 , A61P27/02
摘要： The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.
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公开(公告)号：US09977023B2
公开(公告)日：2018-05-22
申请号：US15531618
申请日：2015-11-26
发明人： Soon-young Paik , Yu-jeong Won
IPC分类号： G01N33/569 , C12Q1/68 , C12Q1/70 , C12N7/00
CPC分类号： G01N33/56983 , C12N7/00 , C12N2710/10321 , C12N2720/12321 , C12N2770/12021 , C12N2770/16021 , C12N2770/32021 , C12N2770/32421 , C12Q1/68 , C12Q1/701 , C12Q1/706 , G01N2333/075 , G01N2333/08 , G01N2333/10 , G01N2333/14 , Y02A50/451 , Y02A50/54
摘要： The present invention relates to a composition comprising a probe for detecting six representative causative viruses of acute enteritis (norovirus genogroup I and genogroup II, rotavirus, hepatitis A virus, coxsackievirus, astrovirus, and adenovirus), and a DNA microarray, a kit, and a detection method comprising the composition. The present invention is effective due to high specificity and sensitivity to viruses. In addition, since the causative viruses can simply be detected at low cost compared to conventional detection methods, without expensive diagnosis devices or specialists, the present invention may be effectively used as a method for diagnosing viruses causing acute enteritis.
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公开(公告)号：US09707001B2
公开(公告)日：2017-07-18
申请号：US14116338
申请日：2011-12-29
申请人： Seok Jung Kim , Min Hyun Kim
发明人： Seok Jung Kim , Min Hyun Kim
CPC分类号： A61B17/1721 , A61B2017/922
摘要： A pin guide for the surgical operation of an avascular necrosis of a femoral head includes a guide body having a central pin guide hole extending along a centerline of the guide body and a plurality of side pin guide holes formed so as to make a specified angle with the central pin guide hole. The side pin guide holes are radially arranged around the central pin guide hole at a front side of the guide body and joined to the central pin guide hole at a rear side of the guide body.
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