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公开(公告)号：US06680060B2
公开(公告)日：2004-01-20
申请号：US10135988
申请日：2002-04-29
IPC分类号： C12N700
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , C12N7/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32432 , C12N2770/32434 , Y02A50/464
摘要： A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
摘要翻译： 适用于MRC-5细胞生长的活A型甲型肝炎病毒，其中HAV优选特征在于对于没有灭活的人和动物的有效疫苗施用的合适的衰减特征在于，适于使HAV适应MRC-5生长的方法，疫苗组合物和疫苗接种方法 人类对HAV感染。
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公开(公告)号：US09977023B2
公开(公告)日：2018-05-22
申请号：US15531618
申请日：2015-11-26
发明人： Soon-young Paik , Yu-jeong Won
IPC分类号： G01N33/569 , C12Q1/68 , C12Q1/70 , C12N7/00
CPC分类号： G01N33/56983 , C12N7/00 , C12N2710/10321 , C12N2720/12321 , C12N2770/12021 , C12N2770/16021 , C12N2770/32021 , C12N2770/32421 , C12Q1/68 , C12Q1/701 , C12Q1/706 , G01N2333/075 , G01N2333/08 , G01N2333/10 , G01N2333/14 , Y02A50/451 , Y02A50/54
摘要： The present invention relates to a composition comprising a probe for detecting six representative causative viruses of acute enteritis (norovirus genogroup I and genogroup II, rotavirus, hepatitis A virus, coxsackievirus, astrovirus, and adenovirus), and a DNA microarray, a kit, and a detection method comprising the composition. The present invention is effective due to high specificity and sensitivity to viruses. In addition, since the causative viruses can simply be detected at low cost compared to conventional detection methods, without expensive diagnosis devices or specialists, the present invention may be effectively used as a method for diagnosing viruses causing acute enteritis.
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公开(公告)号：US6113912A
公开(公告)日：2000-09-05
申请号：US475886
申请日：1995-06-07
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K39/29 , A61P31/12 , C07K14/10 , C12N7/00 , C12N7/01 , C12N7/08 , C12N15/51 , C12P21/02 , C12R1/91 , H61K39/29
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , C12N7/00 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , C12N2770/32421 , C12N2770/32422 , C12N2770/32432 , C12N2770/32434
摘要： A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
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公开(公告)号：US20170356912A1
公开(公告)日：2017-12-14
申请号：US15531618
申请日：2015-11-26
发明人： Soon-young PAIK , Yu-jeong WON
IPC分类号： G01N33/569 , C12Q1/68 , C12Q1/70 , C12N7/00
CPC分类号： G01N33/56983 , C12N7/00 , C12N2710/10321 , C12N2720/12321 , C12N2770/12021 , C12N2770/16021 , C12N2770/32021 , C12N2770/32421 , C12Q1/68 , C12Q1/701 , C12Q1/706 , G01N2333/075 , G01N2333/08 , G01N2333/10 , G01N2333/14 , Y02A50/451 , Y02A50/54
摘要： The present invention relates to a composition comprising a probe for detecting six representative causative viruses of acute enteritis (norovirus genogroup I and genogroup II, rotavirus, hepatitis A virus, coxsackievirus, astrovirus, and adenovirus), and a DNA microarray, a kit, and a detection method comprising the composition. The present invention is effective due to high specificity and sensitivity to viruses. In addition, since the causative viruses can simply be detected at low cost compared to conventional detection methods, without expensive diagnosis devices or specialists, the present invention may be effectively used as a method for diagnosing viruses causing acute enteritis.
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公开(公告)号：USRE37381E1
公开(公告)日：2001-09-18
申请号：US08673408
申请日：1995-09-06
申请人： Robert H. Purcell , John R. Ticehurst , Jeffrey I. Cohen , Suzanne U. Emerson , Stephen M. Feinstone , Richard J. Daemer , Ian D. Gust
发明人： Robert H. Purcell , John R. Ticehurst , Jeffrey I. Cohen , Suzanne U. Emerson , Stephen M. Feinstone , Richard J. Daemer , Ian D. Gust
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5254 , C12N7/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32434 , C12N2770/32451 , C12N2770/32464 , Y02A50/464
摘要： The present invention provides an attenuated hepatitis A virus useful as a vaccine.
摘要翻译： 本发明提供可用作疫苗的减毒甲型肝炎病毒。
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公开(公告)号：US5766906A
公开(公告)日：1998-06-16
申请号：US273594
申请日：1994-07-11
申请人： Stanley M. Lemon , David R. Shaffer
发明人： Stanley M. Lemon , David R. Shaffer
CPC分类号： C07K14/005 , C12N7/00 , A61K39/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32461
摘要： Disclosed are live hepatitis A virus deletion mutants having a deletion mutation in the 5' nontranslated region of the viral genome. The deletion mutation may be selected from the group consisting of (a) pY1 deletion mutations that cause the virus to retain the ability to replicate in monkey kidney cells; and (b) deletion mutations between nucleotides 140 and 144 that render the virus temperature sensitive. Advantageously, the deletion mutation may be an attenuating mutation. Pharmaceutical formulations containing such viruses are disclosed, along with the use thereof to produce antibodies useful for diagnostic purposes and for imparting protective immunity against hepatitis A virus.
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公开(公告)号：US20150359871A1
公开(公告)日：2015-12-17
申请号：US14763947
申请日：2014-01-31
IPC分类号： A61K39/12 , A61K39/15 , A61K39/235 , A61K39/145 , C12N7/00 , A61K39/29 , A61K39/125 , A61K39/215 , A61K39/13 , A61K39/285 , A61K39/21
CPC分类号： A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/235 , A61K39/285 , A61K39/29 , A61K39/292 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55588 , C12N7/00 , C12N2710/10021 , C12N2710/10034 , C12N2710/24121 , C12N2710/24134 , C12N2720/12321 , C12N2720/12334 , C12N2740/16021 , C12N2740/16034 , C12N2760/16021 , C12N2760/16034 , C12N2770/20021 , C12N2770/20034 , C12N2770/24021 , C12N2770/24034 , C12N2770/24221 , C12N2770/24234 , C12N2770/32421 , C12N2770/32434 , C12N2770/32621 , C12N2770/32634 , C12N2795/10134 , C12N2795/14034 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/466
摘要： It is disclosed herein that viruses coated in silica retain infectivity and the capacity to induce an immune response in an infected host. In addition, silicified virus is remarkably resistant to desiccation. Provided herein are methods of inducing a virus-specific immune response in a subject by administering to the subject an effective amount of silicified virus or silicified virus particles. Methods of enhancing a virus-specific cell-mediated immune response (such as a T cell-mediated immune response) in a subject by administering to the subject a silicified virus or silicified virus particles are also described herein. Further provided are immunogenic compositions comprising silicified virus or silicified virus particles, such as compositions useful as vaccines. The immunogenic compositions include a pharmaceutically acceptable carrier and/or an adjuvant.
摘要翻译： 本文公开了用二氧化硅包被的病毒保持感染性和在感染宿主中诱导免疫应答的能力。 此外，硅化病毒对干燥具有显着的抗性。 本文提供了通过向受试者施用有效量的硅化病毒或硅化病毒颗粒来在受试者中诱导病毒特异性免疫应答的方法。 本文还描述了通过向受试者施用硅化病毒或硅化病毒颗粒来增强受试者中病毒特异性细胞介导的免疫应答（例如T细胞介导的免疫应答）的方法。 还提供了包含硅化病毒或硅化病毒颗粒的免疫原性组合物，例如可用作疫苗的组合物。 免疫原性组合物包括药学上可接受的载体和/或佐剂。
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公开(公告)号：US20020176869A1
公开(公告)日：2002-11-28
申请号：US10135988
申请日：2002-04-29
IPC分类号： A01N063/00 , A01N065/00 , A61K039/29 , C12N007/00 , C12N007/01 , C12N007/08 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , C12N7/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32432 , C12N2770/32434 , Y02A50/464
摘要： A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
摘要翻译： 适用于MRC-5细胞生长的活A型甲型肝炎病毒，其中HAV优选特征在于对于没有灭活的人和动物的有效疫苗施用的合适的衰减特征在于，适于使HAV适应MRC-5生长的方法，疫苗组合物和疫苗接种方法 人类对HAV感染。
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9.发明授权Hepatitis A virus deletion mutants and vaccine formulations containing the same 失效甲型肝炎病毒缺失突变体和含有相同的疫苗制剂
公开(公告)号：US6136322A
公开(公告)日：2000-10-24
申请号：US94919
申请日：1998-06-15
申请人： Stanley M. Lemon , David R. Shaffer
发明人： Stanley M. Lemon , David R. Shaffer
CPC分类号： C07K14/005 , C12N7/00 , A61K39/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32461
摘要： Disclosed are live hepatitis A virus deletion mutants having a deletion mutation in the 5' nontranslated region of the viral genome. The deletion mutation may be selected from the group consisting of (a) pY1 deletion mutations that cause the virus to retain the ability to replicate in monkey kidney cells; and (b) deletion mutations between nucleotides 140 and 144 that render the virus temperature sensitive. Advantageously, the deletion mutation may be an attenuating mutation. Pharmaceutical formulations containing such viruses are disclosed, along with the use thereof to produce antibodies useful for diagnostic purposes and for imparting protective immunity against hepatitis A virus.
摘要翻译： 公开了在病毒基因组的5'非翻译区具有缺失突变的活A型病毒缺失突变体。 缺失突变可以选自（a）导致病毒保留在猴肾细胞中复制能力的pY1缺失突变; 和（b）使得病毒温度敏感的核苷酸140和144之间的缺失突变。 有利地，缺失突变可以是减毒突变。 公开了含有这种病毒的药物制剂及其用于产生用于诊断目的的抗体和赋予针对甲型肝炎病毒的保护性免疫的用途。
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公开(公告)号：US09993543B2
公开(公告)日：2018-06-12
申请号：US14763947
申请日：2014-01-31
IPC分类号： A61K39/12 , C12N7/00 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/235 , A61K39/285 , A61K39/29 , A61K39/00
CPC分类号： A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/235 , A61K39/285 , A61K39/29 , A61K39/292 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55588 , C12N7/00 , C12N2710/10021 , C12N2710/10034 , C12N2710/24121 , C12N2710/24134 , C12N2720/12321 , C12N2720/12334 , C12N2740/16021 , C12N2740/16034 , C12N2760/16021 , C12N2760/16034 , C12N2770/20021 , C12N2770/20034 , C12N2770/24021 , C12N2770/24034 , C12N2770/24221 , C12N2770/24234 , C12N2770/32421 , C12N2770/32434 , C12N2770/32621 , C12N2770/32634 , C12N2795/10134 , C12N2795/14034 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/466
摘要： It is disclosed herein that viruses coated in silica retain infectivity and the capacity to induce an immune response in an infected host. In addition, silicified virus is remarkably resistant to desiccation. Provided herein are methods of inducing a virus-specific immune response in a subject by administering to the subject an effective amount of silicified virus or silicified virus particles. Methods of enhancing a virus-specific cell-mediated immune response (such as a T cell-mediated immune response) in a subject by administering to the subject a silicified virus or silicified virus particles are also described herein. Further provided are immunogenic compositions comprising silicified virus or silicified virus particles, such as compositions useful as vaccines. The immunogenic compositions include a pharmaceutically acceptable carrier and/or an adjuvant.
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