System for manipulating samples in liquid droplets

    公开(公告)号:US11543383B2

    公开(公告)日:2023-01-03

    申请号:US15818428

    申请日:2017-11-20

    Abstract: A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

    Microplate processing device
    73.
    发明授权

    公开(公告)号:US11519926B2

    公开(公告)日:2022-12-06

    申请号:US16497759

    申请日:2018-05-25

    Abstract: A microplate processing device having at least one carriage with a first receptacle for microplates where the at least one carriage is movable in a first horizontal direction, and having at least one lift that is movable in a vertical direction, where the microplates can be removed from and supplied to the carriage, the carriage has a through-opening, the periphery, in the vertical projection, can at least in part be situated horizontally within the periphery of a microplate held in the carriage, and the lift has a second receptacle for microplates, the periphery, in the vertical projection, is situated within the periphery of the through-opening, where the second receptacle can be moved unhindered through the through-opening in the vertical direction.

    ITERATIVE LIQUID ASPIRATION
    74.
    发明申请

    公开(公告)号:US20220196696A1

    公开(公告)日:2022-06-23

    申请号:US17554221

    申请日:2021-12-17

    Abstract: A method for aspirating a first liquid medium of two liquid media of different density from a sample container comprises: lowering a pipette of the laboratory automation device into the sample container until a pipette tip of the pipette has passed a lowering distance from the surface of the first liquid medium in the sample container, wherein the lowering distance is chosen, such that the pipette tip passes at least an aspiration volume in the sample container; aspirating liquid from the sample container during the lowering of the pipette by generating an underpressure in the pipette, wherein the first liquid medium is aspirated, and after the interface and the pipette tip pass each other, the second liquid medium of the two liquid media is aspirated; measuring a pressure in the pipette during the lowering of the pipette and detecting a position of the interface, when a slope of the pressure changes; when the lowering distance has been passed and no interface is detected, aspirating the aspiration volume from the first liquid medium and dispensing the aspiration volume of the first liquid medium into a further sample container.

    DOOR FOR A LABORATORY WORKSTATION
    75.
    发明申请

    公开(公告)号:US20220195752A1

    公开(公告)日:2022-06-23

    申请号:US17553363

    申请日:2021-12-16

    Abstract: A door for a laboratory workstation is disclosed. The laboratory workstation has a horizontally extending work surface for providing a working area. The door is movable in relation to the work surface in a vertical direction perpendicular to the work surface between a safety position, in which the door closes the working area for manual access of a user, an access position in which the working area is open for manual access of a user, and a loading position.

    PARALLEL GRIPPER WITH ADAPTIVE CLAMPING SURFACES

    公开(公告)号:US20220176571A1

    公开(公告)日:2022-06-09

    申请号:US17465274

    申请日:2021-09-02

    Abstract: The invention relates to an arrangement of a gripper finger and a clamp for use in an automated parallel gripper comprising first and second gripper fingers that are moveable in a direction of translation (y), whereby the clamp is connected to the gripper finger at an underside thereof, so as to be rotational about a vertical axis of rotation (135). The clamp has a front face with a contact surface for engagement with a lateral edge of an item to be gripped and has a default orientation in which the front face is parallel to a lateral direction (x) that is perpendicular to the direction of translation (y) and to the vertical rotation axis (135). The arrangement is additionally provided with a self-alignment feature which comprises first and second biasing mechanisms arranged at either side of the rotation axis (135) in lateral direction (x). Each biasing mechanism has a first part (151, 152) connected to the finger and a second part (131, 132) connected to the clamp and is configured to exert a centering force that urges the first and second parts of each biasing mechanism into alignment with each other. When the clamp is in the default orientation, each biasing mechanism is preloaded to exert an equal moment load on the clamp in the direction of translation (y).

    Pipetting device comprising a fluid volume sensor and fluid processing system

    公开(公告)号:US11311872B2

    公开(公告)日:2022-04-26

    申请号:US16309058

    申请日:2017-07-19

    Inventor: Philipp Ott

    Abstract: The invention relates to a pipetting device having tube with an opening at one end for suctioning or discharging a sample fluid, and can be operatively connected to a pressure generation device at the other end. A first electrode is formed on the pipetting device that forms a measuring capacitor together with a second electrode formed by at least one part of the sample fluid and that can be received in the tube and the measuring capacitor is operatively connected to a measuring unit, and the measuring unit is designed to determine a volume of the suctioned or discharged sample fluid according to the capacity of the measuring capacitor. The invention also relates to a fluid processing system having a pipetting device of this type, as well as a method for determining a processed fluid volume during pipetting with a pipetting device of this type.

    Method for the automated classification of a liquid as well as method for the automated adaption of presettings for a capacitive liquid level measurement

    公开(公告)号:US11199433B2

    公开(公告)日:2021-12-14

    申请号:US16157437

    申请日:2018-10-11

    Abstract: A device which has a deliverable sensor, a container for receiving a liquid, a container environment and a signal processing circuit, the input side of which can be connected circuitry-wise to the sensor. The device is designed to perform a capacitive liquid level measurement in normal operation using the sensor, wherein a threshold value can be predefined for the signal processing circuit for normal operation. The device has a classification module which can be connected with an input side or line connection circuitry-wise to the sensor, is designed to make a capacitive measurement of the liquid in the container using the sensor and can be connected circuitry-wise to the signal processing circuit in order to trigger the specification of a threshold value using the sensor for capacitive measurement of the liquid.

    DEVICES AND METHODS FOR CAPACITIVE FOAM DETECTION IN LIQUID CONTAINERS

    公开(公告)号:US20210293738A1

    公开(公告)日:2021-09-23

    申请号:US17258370

    申请日:2019-07-09

    Inventor: Philipp OTT

    Abstract: Devices and corresponding methods for capacitive foam detection in liquid containers are disclosed. The device has a sensor with a measurement electrode having a plurality of sub-electrodes, a bottom plate that is used as a counter electrode for arranging a liquid container, a sensor electronic unit that is connected to the measurement electrode and the bottom plate and is adapted to determine an impedance, in particular a capacitance, between the measurement electrode and the bottom plate, and an evaluation unit, the measurement electrode being arranged substantially perpendicularly to the bottom plate.

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