公开(公告)号：US3812154A

公开(公告)日：1974-05-21

申请号：US9742070

申请日：1970-12-07

申请人： KALI CHEMIE AG

发明人： THIES P

IPC分类号： C07H17/04 ,  C07D15/04

CPC分类号： C07H17/04 ,  Y10S514/824

摘要： A 2,9-DIOXATRICYCLO-(4,3,1,0,3,7)-DECANE OF THE FORMULEA IA AND IB

3-(R2-CH2-),4-(R3-O-),8-R1,10-(CH2=)-2,9-DIOXATRICYCLO-

(4.3.1.0(3,7))DECANE AND

3-(R2-CH2-),8-R1,10-(CH2=)-2,9-DIOXATRICYCLO-

(4.3.1.0(3,7))DECAN-4-ONE

IN WHICH R1 IS ALKOXY OR ARALKOXY, R2 IS HYDROGEN, HALOGEN OR -SCN, R3 IS HYDROGEN OR ACYL, AND THE 10, 11DOUBLE BOND MAY ALSO BE HYDROGENATED. THE COMPOUNDS ARE HYPOTENSIVE AND CENTRALLY DEPRESSANT AND ANALGETIC AGENTS AND ARE USEFUL FOR TREATING ARTERIOSCLEROTIC DISEASES AND AS PSYCHOPHARMACEUTICALS.

公开(公告)号：US1043209A

公开(公告)日：1912-11-05

申请号：US1912674620

申请日：1912-01-31

申请人： DIEFENBACH ADOLF

发明人： DIEFENBACH ADOLF

CPC分类号： C07H17/04

公开(公告)号：US20240272146A1

公开(公告)日：2024-08-15

申请号：US17701399

申请日：2022-03-22

申请人： AAT Bioquest, Inc.

发明人： Zhenjun DIWU ,  Qinglin MENG ,  Ruogu PENG ,  Qin ZHAO

IPC分类号： G01N33/52 ,  C07H17/04 ,  G01N33/68

CPC分类号： G01N33/52 ,  C07H17/04 ,  G01N33/6803

摘要： The disclosure provides chromogenic and fluorogenic compounds comprising amino acid or peptide appendages that are capable of detecting an activity in a bioassay. Also provided herein are methods for detecting a biological activity in a sample with the subject chromogenic and fluorogenic compounds. In one embodiment, provided herein is a method for detecting endotoxin in a sample. Further provided herein are kits including the subject chromogenic and fluorogenic compounds for detecting a biological activity in a sample.

公开(公告)号：US20240270781A1

公开(公告)日：2024-08-15

申请号：US18290641

申请日：2021-10-19

申请人： GUANGZHOU HANFANG PHARMACEUTICAL CO., LTD.

发明人： Wendong XU ,  Cheng YUAN ,  Shunzhi TANG ,  Juyan LIU ,  Hongfei CAI ,  Bai BAI ,  Jing LI ,  Yuping FU ,  Songtao LI ,  Wancai PENG ,  Yonghua LI ,  Yao LI ,  Jirong LI ,  Shaoheng WEI ,  Jiali LI

IPC分类号： C07H17/04

CPC分类号： C07H17/04

摘要： Provided in the present disclosure is a preparation method of paeoniflorin-6′-O-benzene sulfonate. The method uses crude paeoniflorin instead of paeoniflorin as a raw material, which more complies with actual requirements of an industrial production process of paeoniflorin-6′-O-benzene sulfonate, and uses an organometallic catalyst, an acid-binding agent and chemically active benzenesulfonyl chloride to react with paeoniflorin. Compared with the prior art, the method significantly increases the yield of crude paeoniflorin-6′-O-benzene sulfonate which is separated and purified by means of column chromatography and then refined to obtain paeoniflorin-6′-O-benzenesulfonate with a content of at least 98%, thereby realizing industrial production of the paeoniflorin-6′-O-benzene sulfonate.

公开(公告)号：US20240067634A1

公开(公告)日：2024-02-29

申请号：US18266688

申请日：2021-12-16

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： David H. Sherman ,  Morgan T. McCauley ,  Nolan Carney ,  Andrew W. Robertson ,  Mark M. Painter ,  Kathleen L. Collins ,  Ashootosh Tripathi ,  Alanna R. Condren

IPC分类号： C07D407/06 ,  A61P31/18 ,  C07D407/14 ,  C07H17/04

CPC分类号： C07D407/06 ,  A61P31/18 ,  C07D407/14 ,  C07H17/04

摘要： This disclosure relates generally to inhibitors of MHC-I downmodulation, and methods of treating or preventing an HIV infection by administering the inhibitors to a patient in need of treatment thereof.

公开(公告)号：US11858955B2

公开(公告)日：2024-01-02

申请号：US17929298

申请日：2022-09-01

申请人： MARS, INCORPORATED

发明人： John Didzbalis ,  John P. Munafo

IPC分类号： C07H17/04 ,  A23L27/20 ,  A23G4/06 ,  C07H15/04 ,  A23L27/00

CPC分类号： C07H17/04 ,  A23G4/06 ,  A23L27/2052 ,  A23L27/88 ,  C07H15/04

摘要： A flavor composition containing at least one HMG glucoside compound that can be used to enhance the taste of edible compositions including sweet goods, such as confectionery goods, and savory goods, such as pet foods.

公开(公告)号：US20170369519A1

公开(公告)日：2017-12-28

申请号：US15488603

申请日：2017-04-17

申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION

发明人： Young Ho RHEE ,  Mijin KIM ,  Soyeong KANG

IPC分类号： C07H17/04 ,  C07H15/04 ,  C07H3/06 ,  C07H3/04 ,  C07D407/12 ,  C07D309/10 ,  C07D307/32 ,  C07H15/207 ,  C07C43/215

CPC分类号： C07H17/04 ,  C07C43/215 ,  C07C43/315 ,  C07C2601/14 ,  C07D307/32 ,  C07D309/10 ,  C07D407/12 ,  C07H3/04 ,  C07H3/06 ,  C07H15/04 ,  C07H15/207

摘要： The present invention relates to a method for the stereoselective preparation of apiose derivatives from allylic alcohol compounds and allene compounds using catalytic asymmetric synthesis. The method for the stereoselective preparation of apiose derivatives of the present invention is based on the catalytic asymmetric synthesis from allylic alcohol compounds and allene compounds in the presence of a metal catalyst, so that apiose derivatives can be produced stereoselectively, with high yield, with high optical purity regardless of the types of substituents of the compounds. The method of the invention can also be used for the preparation of oligosaccharides including monosaccharides, disaccharides, and polysaccharides or various compounds including apiose derivatives because the method can minimize the production of by-products without using an activating group, unlike the conventional method for the preparation of adipose derivatives.

公开(公告)号：US20170119806A1

公开(公告)日：2017-05-04

申请号：US15301328

申请日：2015-03-31

申请人： OHIO STATE INNOVATION FOUNDATION

发明人： Alan Douglas Kinghorn ,  Yulin Ren ,  Heebyung Chai ,  James Robert Fuchs ,  Jack Charles Yalowich ,  Jianhua Yu ,  John Woodward

IPC分类号： A61K31/7048 ,  A61K31/365 ,  A61N5/10 ,  A61K45/06

CPC分类号： A61K31/7048 ,  A61K31/365 ,  A61K45/06 ,  A61N5/10 ,  C07H17/04 ,  A61K2300/00

摘要： A series of natural products including phyllanthusum, an arylnaphthalene lignan derivative, with anticancer and antitumor and immunostimulating activity are disclosed. The invention further encompasses methods of adding water solubilizing groups to the arylrings that include phosphonyl groups.

公开(公告)号：US20170095494A1

公开(公告)日：2017-04-06

申请号：US15126435

申请日：2015-03-16

申请人： Nutra Canada Inc. ,  Universite Laval

发明人： Sebastien LEONHART ,  Andre GOSSELIN ,  Andre MARETTE ,  Genevieve PILON ,  Paul ANGERS ,  Yves DESJARDINS ,  Stephanie DUDONNE ,  Pascal DUBE

IPC分类号： A61K31/7034 ,  A61K36/73

CPC分类号： A61K31/7034 ,  A23L5/00 ,  A23L33/105 ,  A61K36/73 ,  A61K2236/00 ,  C07H17/04

摘要： A composition of purified and biologically active p-coumaroyl hexose and/or polyphenols is provided by separation from strawberry's pulp by a method of extraction and purification using a hydrophobic adsorbent using GRAS solvent. Also provided is the use of the composition.

公开(公告)号：US20170073321A1

公开(公告)日：2017-03-16

申请号：US15310641

申请日：2015-05-13

申请人： The University of Tokyo

发明人： Yasuteru URANO ,  Mako KAMIYA ,  Tomohiro DOURA

IPC分类号： C07D311/04 ,  C12Q1/40

CPC分类号： C07D311/04 ,  C07H17/04 ,  C12Q1/40 ,  G01N2333/938

摘要： Provided is an enzyme-specific fluorescent compound capable of being retained in cells, which can emit fluorescence specifically in a target cell, particularly a cell capable of expressing a reporter enzyme such as β-galactosidase, and can covalently bind to a protein in the cell to exhibit an excellent property of being retained in the cell. The fluorescent compound comprises a compound represented by formula (I′) or a salt thereof. In formula (I′), A, X, Y and R1 to R9 are as described in claim 1.

摘要翻译： 提供能够保留在细胞中的酶特异性荧光化合物，其可以在靶细胞，特别是能够表达报告酶如β-半乳糖苷酶的细胞中特异性发射荧光，并且可以共价结合细胞中的蛋白质 以表现出保留在细胞中的优异性质。 荧光化合物包含由式（I'）表示的化合物或其盐。 在式（I'）中，A，X，Y和R 1至R 9如权利要求1所述。