公开(公告)号：US20020115606A1

公开(公告)日：2002-08-22

申请号：US09973964

申请日：2001-10-11

Applicant: Myriad Genetics, Inc.

Inventor： Jean-Marc Roch ,  Paul L. Bartel ,  Karen Heichman

IPC: A61K038/17

CPC classification number: G01N33/6896 ,  C07K14/47 ,  C07K14/4711 ,  C07K2319/00 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/156 ,  G01N2500/02 ,  G01N2800/28 ,  C12Q2565/201

Abstract: The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20020106676A1

公开(公告)日：2002-08-08

申请号：US09973963

申请日：2001-10-11

Applicant: Myriad Genetics, Inc.

Inventor： Jean-Marc Roch ,  Paul L. Bartel ,  Karen Heichman

IPC: C12Q001/68 ,  C07H021/04 ,  C12N009/64 ,  C12P021/02 ,  C12N005/06

CPC classification number: G01N33/6896 ,  C07K14/47 ,  C07K14/4711 ,  C07K2319/00 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/156 ,  G01N2500/02 ,  G01N2800/28 ,  C12Q2565/201

Abstract: The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20020094519A1

公开(公告)日：2002-07-18

申请号：US10092825

申请日：2002-03-07

Applicant: AGENCOURT BIOSCIENCE CORPORATION

Inventor： Kevin J. McKernan ,  Joel A. Malek ,  Paul J. McEwan

IPC: C12Q001/00 ,  C12Q001/68

CPC classification number: C12N15/1055 ,  C12Q1/6897 ,  C12Q2565/201

Abstract: The present invention provides methods for determining the sequence of nucleic acids encoding interacting polypeptide sequences. Two hybrid assays are carried out to select host cells containing nucleotide sequences encoding interacting proteins. The identity of the nucleotide sequences is determined by isolating the nucleotide sequences from the selected host cells and carrying out sequencing reactions on the nucleotide sequences.

Abstract translation: 本发明提供了确定编码相互作用多肽序列的核酸序列的方法。 进行两个杂交测定以选择含有编码相互作用蛋白的核苷酸序列的宿主细胞。 通过从所选择的宿主细胞中分离核苷酸序列并在核苷酸序列上进行测序反应来确定核苷酸序列的身份。

公开(公告)号：US20020072088A1

公开(公告)日：2002-06-13

申请号：US09757309

申请日：2001-01-09

Inventor： Roger Brent ,  C. Wilson Xu ,  Andrew R. Mendelsohn ,  Walter L. Lok

IPC: C12P021/06

CPC classification number: C07K14/4705 ,  C07K14/4738 ,  C07K14/82 ,  C07K2319/00 ,  C07K2319/61 ,  C07K2319/71 ,  C07K2319/80 ,  C12N15/1055 ,  C12N15/62 ,  C12N15/81 ,  C12Q1/025 ,  C12Q1/6897 ,  G01N33/566 ,  G01N33/581 ,  C12Q2565/201

Abstract: Disclosed herein are methods for detecting complex protein interactions and protein functional relationships, and reagents for carrying out those methods.

Abstract translation: 本文公开了用于检测复合蛋白质相互作用和蛋白质功能关系的方法以及用于实施这些方法的试剂。

公开(公告)号：US06365361B1

公开(公告)日：2002-04-02

申请号：US09514247

申请日：2000-02-28

Applicant: Tomoyasu Taniguchi ,  Junko Mizukami

Inventor： Tomoyasu Taniguchi ,  Junko Mizukami

IPC: G01N3353

CPC classification number: G01N33/566 ,  C12Q1/6897 ,  G01N2333/70567 ,  G01N2500/02 ,  C12Q2565/201

Abstract: A method for identifying or screening an agonist for or antagonist to a peroxisome proliferator activated receptor (PPAR) which comprises allowing a test cell and a substance to be tested to coexist, and detecting a change in a ligand-dependent interaction between the PPAR and a coactivator in the test cells due to the substance to be tested by measuring the expression of a reporter gene as an index.

Abstract translation: 用于鉴定或筛选过氧化物酶体增殖物激活受体（PPAR）激动剂或拮抗剂的方法，其包括使测试细胞和被测试物质共存并检测PPAR与α受体之间配体依赖性相互作用的变化 由于通过测量报告基因的表达作为指标而要测试的物质，在测试细胞中的共激活剂。

公开(公告)号：US06171792B2

公开(公告)日：2001-01-09

申请号：US09189653

申请日：1998-11-10

Applicant: Roger Brent ,  C. Wilson Xu ,  Andrew R. Mendelsohn ,  Walter L. Lok

Inventor： Roger Brent ,  C. Wilson Xu ,  Andrew R. Mendelsohn ,  Walter L. Lok

IPC: C12Q100

CPC classification number: C07K14/4705 ,  C07K14/4738 ,  C07K14/82 ,  C07K2319/00 ,  C07K2319/61 ,  C07K2319/71 ,  C07K2319/80 ,  C12N15/1055 ,  C12N15/62 ,  C12N15/81 ,  C12Q1/025 ,  C12Q1/6897 ,  G01N33/566 ,  G01N33/581 ,  C12Q2565/201

Abstract: Disclosed herein are methods for detecting complex protein interactions and protein functional relationships, and reagents for carrying out those methods.

Abstract translation: 本文公开了用于检测复合蛋白质相互作用和蛋白质功能关系的方法以及用于实施这些方法的试剂。