公开(公告)号：US20140170198A1

公开(公告)日：2014-06-19

申请号：US14188790

申请日：2014-02-25

Applicant: Eden Research PLC

Inventor： Lanny Franklin ,  Gary Ostroff

IPC: A01N25/08 ,  A01N31/02 ,  A01N31/08 ,  A01N35/04 ,  A01N31/14

CPC classification number: A01N25/08 ,  A01N31/02 ,  A01N31/08 ,  A01N31/14 ,  A01N31/16 ,  A01N35/02 ,  A01N35/04 ,  A01N35/06 ,  A01N2300/00

Abstract: The present invention relates to compositions comprising terpenes which are particularly suitable for treating plant infections, to methods of making such compositions, and to methods of using them. The present invention also relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions; such compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. In particular, the terpenes disclosed are thymol, eugenol, geraniol, citral and L-carvone.

Abstract translation: 本发明涉及包含特别适合于治疗植物感染的萜烯的组合物，制备这种组合物的方法以及使用它们的方法。 本发明还涉及包含萜烯和中空葡聚糖颗粒或细胞壁颗粒的组合物及其制备方法; 这样的组合物增加萜烯的稳定性和活性，并为萜烯提供合适的载体。 本发明还涉及在医疗，兽医和农业领域中使用这种组合物的方法。 特别地，所公开的萜烯是百里香酚，丁子香酚，香叶醇，柠檬醛和L-香芹酮。

公开(公告)号：US08673865B2

公开(公告)日：2014-03-18

申请号：US11885387

申请日：2006-02-27

Applicant: Katsuya Ueno ,  Hiromoto Mizushima ,  Hiromi Kubota ,  Katsumi Endo

Inventor： Katsuya Ueno ,  Hiromoto Mizushima ,  Hiromi Kubota ,  Katsumi Endo

IPC: A01N43/04 ,  A01N31/00 ,  A01N31/08 ,  A61K31/70 ,  A61K31/045 ,  A61K31/05

CPC classification number: A61K31/7004 ,  A61K8/602 ,  A61Q19/005

Abstract: The present invention relates to a preservative efficacy-enhancing agent capable of allowing an antiseptic agent to exhibit a high preservative efficacy even when the antiseptic agent is used at a low concentration; a preservative efficacy-enhancing composition containing the same; and a method for enhancing a preservative efficacy of antiseptic agents. The present invention relates to: (1) a preservative efficacy-enhancing agent for antiseptic agents which includes an amphiphilic galactose derivative (A) as an effective ingredient; (2) a preservative efficacy-enhancing composition including 0.01 to 30% by mass of an amphiphilic galactose derivative (A) and 0.01 to 1.0% by mass of an antiseptic agent (B); and (3) a method for enhancing a preservative efficacy of an antiseptic composition which includes the step of allowing 0.01 to 30% by mass of an amphiphilic galactose derivative (A) to coexist with an antiseptic agent (B) in the composition.

Abstract translation: 本发明涉及一种防腐剂功效增强剂，即使在低浓度使用防腐剂时，也能够使防腐剂表现出高的防腐效果; 含有该组合物的防腐效能增强组合物; 以及提高防腐剂的防腐效果的方法。 本发明涉及：（1）防腐剂的防腐功效增强剂，其包含两亲性半乳糖衍生物（A）作为有效成分; （2）含有0.01〜30质量％的两亲性半乳糖衍生物（A）和0.01〜1.0质量％的防腐剂（B）的防腐效能增强组合物。 （3）提高防腐剂组合物的防腐功效的方法，其包括使0.01〜30质量％的两亲半乳糖衍生物（A）与组合物中的防腐剂（B）共存的步骤。

公开(公告)号：US08669292B2

公开(公告)日：2014-03-11

申请号：US12425574

申请日：2009-04-17

Applicant: Jerome Godin

Inventor： Jerome Godin

IPC: A01N35/00 ,  A61K31/12 ,  A01N31/08 ,  A61K31/05 ,  A01N31/14 ,  A61K31/075 ,  A01N43/08 ,  A61K31/34

CPC classification number: A61K9/08 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/19 ,  A61K31/05 ,  A61K31/12 ,  A61K31/19 ,  A61K31/352 ,  A23V2250/21

Abstract: The invention provides compositions and formulations comprising catechol and/or acetogenins and various combinations thereof; including various combinations with other ingredients including botanical preparations containing acetogenin, an extract of green tea or a therapeutically active flavanoid contained in green tea; and one or more quinones. The invention includes a pharmaceutical composition including a salt of rhodizonic acid, an OH anion-generating base, a non-toxic acid, a quinone, a salt-containing sulfite, catechol and optionally, an acetogenin and an extract of green tea. The compositions and formulations demonstrate positive effects against a broad variety of cancer, autoimmune diseases, viruses and provides antioxidant protection against peroxyl hydrophilic, peroxyl lipophilic, hydroxyl, peroxynitrite and super oxide radicals. The compositions and formulations can be used for nutritional and nutraceutical uses, and used as dietary supplements.

Abstract translation: 本发明提供了包含儿茶酚和/或乙酰青霉素及其各种组合的组合物和制剂; 包括与其他成分的各种组合，包括含有青霉素的植物制剂，绿茶提取物或绿茶中含有的治疗活性类黄酮; 和一种或多种醌。 本发明包括一种药物组合物，其包含铑酸盐，产生OH阴离子的碱，无毒酸，醌，含盐亚硫酸盐，儿茶酚和任选的乙酰辅酶和绿茶提取物。 组合物和制剂对各种癌症，自身免疫疾病，病毒表现出积极的作用，并提供抗过氧化亲水性，过氧基亲脂性，羟基，过氧亚硝酸盐和超氧化物基团的抗氧化保护。 组合物和制剂可用于营养和营养用途，并用作膳食补充剂。

公开(公告)号：US08652444B2

公开(公告)日：2014-02-18

申请号：US13292174

申请日：2011-11-09

Applicant: Ravi Subramanyam ,  Prem Sreenivasan

Inventor： Ravi Subramanyam ,  Prem Sreenivasan

IPC: A01N31/08 ,  A61K31/05 ,  A61K8/00 ,  A61K8/18 ,  A61Q11/00

CPC classification number: A61K8/347 ,  A61Q11/00

Abstract: Antiplaque oral compositions are provided that contain an orally acceptable carrier and an antibacterial effective amount of the compound of formula (I). In various embodiments, the compositions contain from about 0.001% to about 10% by weight of the compound of formula (I).

Abstract translation: 提供了抗口腔组合物，其含有口服可接受的载体和抗菌有效量的式（I）化合物。 在各种实施方案中，组合物含有约0.001％至约10％重量的式（I）化合物。

公开(公告)号：US08604087B2

公开(公告)日：2013-12-10

申请号：US13120818

申请日：2009-09-25

Applicant: Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Sang iL Lee

Inventor： Ki Ho Kim ,  Ki Soo Kim ,  Young Heui Kim ,  Jin Guk Kim ,  Kyoung Tae Kim ,  Chang Sung Han ,  Sang iL Lee

IPC: A01N31/04 ,  A01N31/08

CPC classification number: A61K31/085 ,  A23L2/52 ,  A23L33/105 ,  A61K31/05 ,  A61K36/575

Abstract: Disclosed is a composition for treating or preventing amyloid-related diseases including 4-O-methylhonokiol as an active ingredient. More specifically, a pharmaceutical composition including 4-O-methylhonokiol, which is effective for treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorder, defective memory, amyloidosis, etc. is disclosed. The inventors of the present disclosure have found out for the first time that 4-O-methylhonokiol inhibits the production of β-amyloid. It has been confirmed to be useful in treating or preventing amyloid-related diseases. Through animal tests including water maze test and passive avoidance test on mice, 4-O-methylhonokiol has been confirmed to be effective for amyloid-related diseases such as Alzheimer's disease, defective memory, cognitive disorder, and the like. It was further confirmed through acetylcholinesterase activity inhibition test using mouse brain cortex and hippocampus tissue that they are particularly effective in treating or preventing Alzheimer's disease among the amyloid-related diseases.

Abstract translation: 公开了用于治疗或预防淀粉样蛋白相关疾病的组合物，包括4-O-甲基联苯甲醇作为活性成分。 更具体地说，公开了一种药物组合物，其包含对于治疗或预防淀粉样蛋白相关疾病如阿尔茨海默氏病，认知障碍，缺陷记忆，淀粉样变性等有效的4-O-甲基联苯甲醇。 本公开的发明人首次发现4-O-甲基联苯酚抑制β-淀粉样蛋白的产生。 已经证实可用于治疗或预防淀粉样蛋白相关疾病。 通过动物试验，包括水迷宫试验和小鼠被动回避试验，已证实4-O-甲基黑叶醇对淀粉样蛋白相关疾病如阿尔茨海默病，记忆缺陷，认知障碍等有效。 通过使用小鼠脑皮层和海马组织的乙酰胆碱酯酶活性抑制试验进一步证实，它们在淀粉样蛋白相关疾病中治疗或预防阿尔茨海默氏病方面特别有效。

公开(公告)号：US20130156708A1

公开(公告)日：2013-06-20

申请号：US13660252

申请日：2012-10-25

Applicant: Symrise AG

Inventor： Manuel Pesaro ,  Heiko Oertling

IPC: A01N31/08 ,  A01N31/14 ,  A61Q17/00 ,  A61K8/34 ,  A61Q17/04 ,  C07C39/19 ,  A01N37/40

CPC classification number: A01N31/08 ,  A01N31/14 ,  A01N37/40 ,  A23L33/10 ,  A61K8/34 ,  A61K8/347 ,  A61K9/0014 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q9/04 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/005 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/002 ,  A61Q19/004 ,  A61Q19/005 ,  A61Q19/08 ,  A61Q19/10 ,  C07C39/19 ,  C11D3/2034 ,  C11D3/48 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/49 ,  Y02A50/491 ,  A01N25/28 ,  A01N31/02 ,  A01N31/16 ,  A01N33/12 ,  A01N37/02 ,  A01N37/10 ,  A01N37/34 ,  A01N43/16 ,  A01N43/40 ,  A01N43/50 ,  A01N43/80 ,  A01N47/30 ,  A01N47/44 ,  A01N59/16 ,  A01N65/08 ,  A01N65/12 ,  A01N65/18 ,  A01N65/20 ,  A01N65/24 ,  A01N65/34 ,  A01N65/40 ,  A01N65/44

Abstract: The invention relates to the use of (i) a compound of formula (I) or a (pharmaceutically) acceptable salt thereof or (ii) a mixture comprising one or more or consisting of two or more compounds of formula (I) and/or said salts wherein R1 denotes a radical in ortho-, meta, or para-position to the phenolic OH group, the radical being selected from the group consisting of E/Z-3-methylbut-1-en-1-yl, 3-methylbut-2-en-1-yl and 3-methylbut-3-en-1-yl and R2 denotes a radical in ortho-, meta, or para-position to the phenolic OH group, the radical being selected from the group consisting of H and alkyl groups with 1 to 3 C atoms as antimicrobial agent for inactivation of microorganisms, in particular for rapid inactivation of microorganisms, with the proviso that the use is not within a method for treatment of the human or animal body by surgery or therapy or within a diagnostic method practised on the human or animal body.

Abstract translation: 本发明涉及（i）式（I）化合物或其（药学上可接受的盐）或（ii）包含一种或多种或由两种或更多种式（I）化合物和/或 所述盐，其中R1表示在酚OH基团的邻位，间位或对位的基团，所述基团选自E / Z-3-甲基丁-1-烯-1-基，3- 甲基丁-2-烯-1-基和3-甲基丁-3-烯-1-基，R 2表示在酚OH基团的邻位，间位或对位的基团，该基团选自 的H和具有1至3个C原子的烷基作为用于灭活微生物的抗微生物剂，特别是用于微生物的快速灭活，条件是使用不在用于通过手术或治疗来治疗人或动物体的方法 或在人体或动物体上实施的诊断方法。

公开(公告)号：US20130102464A1

公开(公告)日：2013-04-25

申请号：US13807531

申请日：2011-07-01

Applicant: Adeline Bordier

Inventor： Adeline Bordier

IPC: A01N65/03 ,  A01N43/16 ,  A01N31/08

CPC classification number: A01N65/03 ,  A01N31/08 ,  A01N43/16 ,  A01N65/00 ,  A01N65/08 ,  C05F5/004 ,  C05F11/00 ,  C05G3/0064 ,  Y02A40/209 ,  A01N2300/00

Abstract: The invention relates to the use of an extract of grape marc for promoting plant growth and to a method for promoting plant growth which comprises the application of a composition comprising an extract of grape marc to said plants.

Abstract translation: 本发明涉及用于促进植物生长的葡萄糜提取物的使用和促进植物生长的方法，其包括将包含葡萄an提取物的组合物施用于所述植物。

公开(公告)号：US08426475B2

公开(公告)日：2013-04-23

申请号：US11402255

申请日：2006-04-12

Applicant: Morten Sloth Weidner ,  Hans Christian Wulf

Inventor： Morten Sloth Weidner ,  Hans Christian Wulf

IPC: A01N31/08 ,  A01N31/00 ,  A61K31/05 ,  A61K31/045

CPC classification number: A61K31/137 ,  A61K9/0014 ,  A61K31/135

Abstract: The present invention provides effective and safe medicaments for the treatment of connective tissue diseases of the skin, particularly with respect to the treatment of cutaneous forms of Lupus Erythematous. The medicaments comprise as the therapeutically active ingredient a beta2 adrenoceptor agonist. The invention furthermore relates to dermatological compositions without skin sensitization properties and which contain enantiomerically pure or enriched R-enantiomers of a beta2 adrenoceptor agonist.

Abstract translation: 本发明提供了用于治疗皮肤结缔组织疾病的有效和安全的药物，特别是关于治疗皮肤红斑狼疮的方法。 药物作为治疗活性成分包含β2肾上腺素受体激动剂。 本发明还涉及没有皮肤致敏性的皮肤病学组合物，并且其含有β2肾上腺素受体激动剂的对映体纯的或富集的R-对映体。

公开(公告)号：US20120322662A1

公开(公告)日：2012-12-20

申请号：US13581797

申请日：2011-04-15

Applicant: Sang-Ku Yoo ,  Jin Wook Chung

Inventor： Sang-Ku Yoo ,  Jin Wook Chung

IPC: A01N31/08 ,  A01P21/00 ,  C07C39/12 ,  A01N27/00 ,  C07C15/12

CPC classification number: A01N27/00 ,  A01N31/14 ,  A01N55/00 ,  C07C13/28 ,  C07C43/215 ,  C07C2601/02 ,  C07F7/081

Abstract: Disclosed are a method for directly preparing in situ cyclopropenes for inhibiting ethylene action facilitating ripening and aging of plants via reaction of a cyclopropene precursor such as a compound of Formula (2) or Formula (3) with a fluoride (F−) and immediately applying the same to plants, and an aryl group-containing 1-alkylcyclopropene of Formula (6) effective for inhibiting the action of ethylene.

Abstract translation: 公开了直接制备原位环丙烯以抑制乙烯作用的方法，其通过环丙烯前体如式（2）或式（3）的化合物与氟化物（F-）的反应促进植物的熟化和老化，并立即施用 与植物相同，和式（6）的含芳基的1-烷基环丙烯有效抑制乙烯的作用。

公开(公告)号：US20120302647A1

公开(公告)日：2012-11-29

申请号：US13577627

申请日：2010-02-25

Applicant: Basi V. Subba Reddy ,  Jhillu S. Yadav ,  Ravi Subramanyam

Inventor： Basi V. Subba Reddy ,  Jhillu S. Yadav ,  Ravi Subramanyam

IPC: C07C37/18 ,  A01P1/00 ,  C07C41/01 ,  A01N31/08

CPC classification number: C07C41/48 ,  C07C37/055 ,  C07C37/62 ,  C07C41/52 ,  Y02P20/55 ,  C07C39/21 ,  C07C39/367 ,  C07C43/30 ,  C07C43/313

Abstract: A method is described for producing magnolol, or a derivative or analogue thereof. The method includes obtaining MOM ether of 5,5′-diallylbiphenyl-2,2′-diol or a derivative or analogue thereof and subsequently converting the MOM ether of 5,5′-diallylbiphenyl-2,2′-diol into magnolol or a derivative or analogue thereof.

Abstract translation: 描述了制备厚朴酚或其衍生物或类似物的方法。 该方法包括获得5,5'-二烯丙基联苯-2,2'-二醇或其衍生物或类似物的MOM醚，随后将5,5'-二烯丙基联苯-2,2'-二醇的MOM醚转化成厚朴酚或 衍生物或类似物。