公开(公告)号：US20070003611A1

公开(公告)日：2007-01-04

申请号：US11169540

申请日：2005-06-29

申请人： Sung-Tsuen Liu ,  George Skinner

发明人： Sung-Tsuen Liu ,  George Skinner

IPC分类号： A61K9/48 ,  A61K9/46

CPC分类号： A61K33/10 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/205

摘要： A new and useful method of granulating calcium carbonate is provided. Such a method entails the inclusion of very low amounts of an aqueous solution citric acid to a calcium carbonate material, with subsequent, mixing, drying, milling, and sieving to provide the correct target particle size range for the resultant granulated materials. Such granulated calcium carbonate materials exhibit very high available calcium levels, excellent flow characteristics, capability for compression into tablets, and a drastic reduction in needed binders to effectuate the desired granulation itself. Products including such granulated calcium carbonate materials are also encompassed within this invention.

摘要翻译： 提供了一种新的有用的造粒碳酸钙方法。 这种方法需要将非常少量的水溶液柠檬酸包含在碳酸钙材料中，随后进行混合，干燥，研磨和筛分以提供所得粒状材料的正确目标粒度范围。 这种颗粒状碳酸钙材料表现出非常高的可用钙水平，优异的流动特性，压缩成片剂的能力，以及急剧减少所需的粘合剂以实现所需的造粒本身。 包括这种颗粒状碳酸钙材料的产品也包括在本发明内。

公开(公告)号：US07147868B2

公开(公告)日：2006-12-12

申请号：US10380407

申请日：2002-07-08

申请人： Mitsuhiro Sofue ,  Isamu Kawamura ,  Shigeo Yamao ,  Hideaki Baba ,  Shiro Horie ,  Yoko Abe ,  Hisae Sofue

发明人： Mitsuhiro Sofue ,  Isamu Kawamura ,  Shigeo Yamao ,  Hideaki Baba ,  Shiro Horie ,  Yoko Abe ,  Hisae Sofue

IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K9/46

CPC分类号： A61K33/08 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2059

摘要： An antacid and laxative tablet comprising magnesium oxide particles as an effective component, wherein (i) the magnesium oxide particles contained in the tablet have an average secondary particle diameter measured by a laser diffraction scattering method of 0.5 to 10 μm, (ii) the content of magnesium oxide particles in the tablet is 88 wt % or more, (iii) the tablet does not become blackish and has substantially no tableting spot, and (iv) the disintegration time is 10 sec or less. The antacid and laxative tablet of the present invention has a high content of magnesium oxide particles, a short disintegration time, does not become blackish, has no tablet trouble and no tableting spot and is suitably administered orally.

摘要翻译： 一种含有氧化镁粒子作为有效成分的抗酸泻药片，其中，（i）片剂中含有的氧化镁粒子的平均二次粒径通过激光衍射散射法测定为0.5〜10μm，（ii）含量 片剂中的氧化镁颗粒为88重量％以上，（iii）片剂不变黑，基本上不具有压片斑，（iv）崩解时间为10秒以下。 本发明的抗酸泻药片具有高含量的氧化镁颗粒，崩解时间短，不变黑，没有片剂麻烦，没有压片斑点，适合口服施用。

公开(公告)号：US20060240103A1

公开(公告)日：2006-10-26

申请号：US11473044

申请日：2006-06-23

申请人： David McCallister ,  Christer Rosen

发明人： David McCallister ,  Christer Rosen

IPC分类号： A61K9/46 ,  A61K31/66 ,  A61K31/4439

CPC分类号： A61K45/06 ,  A61K9/0007 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/663 ,  A61K2300/00

摘要： The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.

公开(公告)号：US20060188571A1

公开(公告)日：2006-08-24

申请号：US11408614

申请日：2006-04-20

申请人： Azariah Jossifoff

发明人： Azariah Jossifoff

IPC分类号： A61K31/57 ,  A61K9/20 ,  A61K9/46

CPC分类号： A61K31/57 ,  A61K9/0007 ,  A61K9/0034 ,  A61K9/02 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2095

摘要： The present invention provides a method for preparing a tablet for the vaginal administration of progesterone for systemic use. The method comprises first mixing water with micronized progesterone, the total amount of water mixed with said micronized progesterone not exceeding the maximum wetting capacity of the micronized progesterone, drying the wetted, micronized progesterone; mixing the dry micronized progesterone with other pharmaceutically acceptable excipients or diluents; and; forming a tablet by direct compaction of the dry micronized progesterone. Tablets prepared by this method are also provided.

摘要翻译： 本发明提供一种制备用于全身用途的孕酮阴道给药片剂的方法。 该方法包括首先将水与微粉化孕酮混合，与所述微粉化孕酮混合的水的总量不超过微粉化孕酮的最大润湿能力，干燥湿润的微粉化孕酮; 将干微粉化的孕酮与其它药学上可接受的赋形剂或稀释剂混合; 和; 通过直接压实干微粉化孕酮形成片剂。 还提供了通过该方法制备的片剂。

公开(公告)号：US20060099247A1

公开(公告)日：2006-05-11

申请号：US10986101

申请日：2004-11-10

申请人： Evelyna Cantwell ,  John Cantwell ,  Efim Lyublinski ,  Yefim Vaks

发明人： Evelyna Cantwell ,  John Cantwell ,  Efim Lyublinski ,  Yefim Vaks

IPC分类号： A61K9/48 ,  A61K9/46 ,  A61M11/00

CPC分类号： A61M15/00 ,  A61J3/07 ,  A61K9/70 ,  A61M2016/0661 ,  A61M2202/0208 ,  A61M2205/0244 ,  A61M2205/8231 ,  C23F11/02

摘要： This invention relates generally to liquid, gas and/or vapor phase delivery systems and, more particularly, to delivery systems that incorporate at least one layer, film and/or capsule that produces a liquid, gas and/or vapor phase compound or compounds for use therein.

摘要翻译： 本发明一般涉及液体，气体和/或气相输送系统，并且更具体地涉及包含至少一个产生液体，气体和/或气相化合物的层，膜和/或胶囊的输送系统，其用于 在其中使用。

公开(公告)号：US20050263430A1

公开(公告)日：2005-12-01

申请号：US11134289

申请日：2005-05-23

申请人： Sanso' Giovanni

发明人： Sanso' Giovanni

IPC分类号： B65D21/02 ,  B65D81/26 ,  B65D83/04 ,  A61K9/46

CPC分类号： B65D83/0409 ,  B65D21/0228 ,  B65D81/266

摘要： A container for effervescent tablets 3, includes a tube 2 with a base 7 and upper opening closed by a screw cap 4 provided with a seal in polythene. A spring 10 is placed inside the tube 2 and pushes tablets 3 upwards to facilitate extraction thereof. Guide fins 12, placed at the edge of tube 2, stop tablets 3 at this edge and allow their extraction, one at a time, with a transverse thrust. On base 7 is a tablet of drying agent 8, separated from tablets 3 by a perforated divider 9. At the base of tube 2, a storage unit 13 is attached by screwing, closed by a cap 19, and intended to hold at least one tablet or half a tablet separated by a perforated divider 18 from a drying agent tablet 17 placed on base 16.

摘要翻译： 用于泡腾片3的容器包括具有基部7的管2，并且上部开口由在聚乙烯中设置密封的螺帽4封闭。 将弹簧10放置在管2内并向上推动片剂3以便于其提取。 放置在管2边缘处的引导片12在这个边缘处停止片剂3，并允许它们一次一个地以横向推力提取。 基料7是干燥剂8的片剂，通过穿孔分隔物9与片剂3分离。 在管2的基部，存储单元13通过螺纹连接，由盖19封闭，并且用于将由穿孔分隔物18分开的至少一个片剂或半片保持在放置在基座16上的干燥剂片17上 。

公开(公告)号：US20050244347A1

公开(公告)日：2005-11-03

申请号：US10837384

申请日：2004-04-30

申请人： Dev Mehra ,  Michael Withiam ,  John Cornelius

发明人： Dev Mehra ,  Michael Withiam ,  John Cornelius

IPC分类号： A61K8/19 ,  A61K9/00 ,  A61K9/20 ,  A61K9/46 ,  A61Q11/00 ,  A61K7/16

CPC分类号： A61K9/2009 ,  A61K8/19 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61Q11/00

摘要： A rapidly disintegrating oral care tablet is provided. The tablet comprises: a calcium phosphate; a super disintegrant; and a sugar alcohol. When immersed in water the tablet has a friability of less than about 2% and disintegrates in less than about 60 seconds.

摘要翻译： 提供快速崩解的口腔护理片剂。 片剂包括：磷酸钙; 超级崩解剂 和糖醇。 当浸在水中时，片剂具有小于约2％的脆性，并在小于约60秒内分解。

公开(公告)号：US20050238713A1

公开(公告)日：2005-10-27

申请号：US11169969

申请日：2005-06-29

申请人： Thomas Kollars ,  Edwin Masters ,  Jacqueline Masters ,  Peggy Kollars

发明人： Thomas Kollars ,  Edwin Masters ,  Jacqueline Masters ,  Peggy Kollars

IPC分类号： A01M1/02 ,  A01M1/10 ,  A01M1/14 ,  A01M1/22 ,  A61K9/46

CPC分类号： A01M1/103 ,  A01M1/023 ,  A01M1/106 ,  A01M1/14 ,  A01M1/145 ,  A01M1/22 ,  A01M2200/011 ,  A01M2200/012

摘要： An insect and/or arthropod trapping device that generates its own attractants of carbon dioxide (CO2), and ammonia through the chemical reaction of adding a weakly acidic liquid such as vinegar (acetic acid) to solids such as baking soda (sodium bicarbonate), with the optional addition of urea and/or lactic acid. The liquids are mixed over a period of days onto the solids to generate CO2 in the vicinity of an insect/arthropod trap having glue boards that trap the insects and arthropods when they alight on the glue board. The attractants can be used with devices that utilize various combinations of other insect attractants and traps such as sound, light, scent, visual, electrical, chemical, sticky surfaces, mesh nets, etc., to further attract and trap or kill insects and/or arthropods.

公开(公告)号：US20050232988A1

公开(公告)日：2005-10-20

申请号：US10827106

申请日：2004-04-19

申请人： Gopi Venkatesh ,  Ken Qian ,  Shyam Vangala ,  James Clevenger ,  Donald Guenther

发明人： Gopi Venkatesh ,  Ken Qian ,  Shyam Vangala ,  James Clevenger ,  Donald Guenther

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/46 ,  A61K9/50 ,  A61K31/34

CPC分类号： A61K9/2081 ,  A61K9/0056 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2095 ,  A61K9/5042 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4045

摘要： A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.

摘要翻译： 一种在口腔内快速崩解的片剂，其包含通过将平均粒度小于约30微米的糖醇或糖或其混合物制成的快速分散微粒的压缩共混物和崩解剂，以及掩味微胶囊 含有至少一种药物，所述微胶囊通过将包含至少一种治疗有效量的药物的药学上可接受的制剂和至少一种改善微粒回弹性的聚合物粘合剂制粒，湿法研磨造粒物质，并将研磨的颗粒微胶囊化 以提供微胶囊。

公开(公告)号：US20050196441A1

公开(公告)日：2005-09-08

申请号：US10982273

申请日：2004-11-05

申请人： James Dvorsky ,  Brian Graham ,  Sreedhara Alavattam ,  Charles Gegenheimer ,  John Finney ,  Jean Schelhorn ,  Dov Rosenberg ,  Jeffrey Cafmeyer ,  Mark Bauer ,  Robert Fellows ,  Nadim Moucharafieh ,  Ronald Coffee ,  Alastair Pirrie ,  David Davies ,  Johnathan Essex-Lopresti ,  Margaret Wan ,  Anna Busby

发明人： James Dvorsky ,  Brian Graham ,  Sreedhara Alavattam ,  Charles Gegenheimer ,  John Finney ,  Jean Schelhorn ,  Dov Rosenberg ,  Jeffrey Cafmeyer ,  Mark Bauer ,  Robert Fellows ,  Nadim Moucharafieh ,  Ronald Coffee ,  Alastair Pirrie ,  David Davies ,  Johnathan Essex-Lopresti ,  Margaret Wan ,  Anna Busby

IPC分类号： A01N25/10 ,  A01N25/34 ,  A01N51/00 ,  A61K9/46 ,  B05D1/04

CPC分类号： A01N25/34 ,  A01N25/10 ,  A01N51/00 ,  A01N2300/00

摘要： The present invention provides a manufacturing process for quick dissolving products having active ingredients directed to agrochemical applications, such as plant applications and animal and animal health applications. Electrohydrodynamic (EHD) spraying is used to form a product form preferably comprised of fibers that contains a desired agrochemical compound formulated to quickly disintegrate on contact with a solvent such as water. The dispersed chemical is then provided as a sprayable solution. Because the product form contains little or no liquid, significant size and weight savings are gained, higher active ingredient loadings may be placed in a smaller amount of material, and manufacturing, packaging and transportation costs are thereby reduced without impacting user-friendliness. In addition, the EHD manufacturing method of the present invention also permits combining active ingredients previously not capable of effective use together in a single product. Small, low cost and potentially modular production operations may be used to practice the invention, thus enabling production facilities to be located close to markets, and product design specific to local or regional markets.

摘要翻译： 本发明提供了一种用于快速溶解具有针对农业化学应用的活性成分的产品的制造方法，例如植物应用和动物和动物健康应用。 使用电动力学（EHD）喷雾形成优选由纤维组成的产品形式，所述纤维含有配制成在与溶剂如水接触时迅速分解的所需农药化合物。 然后将分散的化学品作为可喷雾溶液提供。 由于产品形式含有很少或不含液体，因此可以大大减轻重量，可以将更多的活性成分负载量放置在较少量的材料中，从而降低制造，包装和运输成本，而不会影响用户友好性。 此外，本发明的EHD制造方法还允许将先前不能有效使用的活性成分组合在一起的单一产品中。 小型，低成本和潜在的模块化生产操作可用于实施本发明，从而使生产设备能够靠近市场，以及特定于当地或区域市场的产品设计。