利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

161 条记录 (耗时 0.041 秒)

    Quinoline derivatives as anti-inflammatory agents
    72.
    发明申请
    Quinoline derivatives as anti-inflammatory agents 失效
    喹啉衍生物作为抗炎剂

    公开(公告)号：US20060084677A1

    公开(公告)日：2006-04-20

    申请号：US11291867

    申请日：2005-11-30

    申请人： Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

    发明人： Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

    IPC分类号： A61K31/47 ,  C07D215/60

    CPC分类号： C07D215/36

    摘要： This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH2, CH(OH), C(O), C═NOR4, NR5, O, S, S(O), or S(O)2, and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

    摘要翻译： 本发明涉及通常为抗炎和止痛化合物的化合物，其由式I表示：其中A是CH 2，CH（OH），C（O），C- NOR 4，NR 5，O，S，S（O）或S（O）2，其它取代基如所定义 在规范中; 或前药，各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法

    Tetrahydroquinoline derivatives
    73.
    发明申请
    Tetrahydroquinoline derivatives 有权

    公开(公告)号：US20040236109A1

    公开(公告)日：2004-11-25

    申请号：US10482707

    申请日：2004-01-02

    发明人： Nicole Corine Renee Van Straten ,  Rudolf Gijsbertus Van Someren ,  Jurgen Schulz

    IPC分类号： C07D215/36 ,  C07D215/60

    CPC分类号： C07D215/38 ,  A61K31/47 ,  A61K31/4709 ,  C07D215/08 ,  C07D215/20 ,  C07D215/48

    摘要： The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is formyl, (1-6C)alkylcarbonyl or (1-6C)alkylsulfonyl; R2 and R3 are H or (1-4C)alkyl; R4 is phenyl; R5 is (1-4C)alkyl; YnullX is (CO)nullO, (SO)2nullO, NHC(O)nullO, NHC(S)nullO, OC(O)nullO, bond-O, C(O)nullNH, S(O)2nullNH, NHC(O)nullNH, NHC(S)nullNH, OC(O)nullNH, bond-NH, NHnullC(O), OnullC(O), NHnullS(O)2, or OnullS(O)2 or YnullX is a bond; R6 is H, trifluormethyl, (1-6C)alkyl, 1- or 2-adamantyl(1-4C)alkyl, (2-6C)alkenyl, (3-9C)heteroaryl, (3-6C)cycloalkyl, (2-6C)heterocycloalkyl, (1-4C)alkylthio(1-4C)alkyl, (6-10C)aryl(1-4C)alkyl, (3-9C)heteroaryl(1-4C)alkyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, R8, R9-aminocarbonyl(1-4C)alkyl, R8, R9-amino(1-4C)alkyl, R8-oxycarbonyl(1-4C)alkyl, R8-oxy(1-4C)alkyl, R8-carbonyl(1-4C)alkyl or (6-10C)aryl; R7 is H, (1-4C)alkyl, (1-4C)alkoxy, halogen, trifluoromethyl, cyano, nitro hydroxyl; and R8 and/or R9 is H, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (6-10C)aryl, (3-9C)heteroaryl, (6-10C)aryl(1-4C)alkyl, (3-9C)heteroaryl(1-4C)alkyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, (1-4C)(di)alkylamino(1-4C)alkyl, (1-4C)alkoxy(1-4C)alkyl, (1-4C)alkylthio(1-4C)alkyl, (1-4C)alkylcarbonylamino(1-4C)alkyl, (1-4C)alkoxycarbonyl(1-4C)alkyl, (1-4C)alkoxycarbonylamino(1-4C)alkyl, (3-6C)cycloalkyl, (2-6C)heterocycloylkyl, or R8 and R9 may be joined in a (2-6C)heterocycloalkyl ring. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to control fertility. 1

    Therapeutic amides
    74.
    发明申请
    Therapeutic amides 有权
    治疗酰胺

    公开(公告)号：US20040132618A1

    公开(公告)日：2004-07-08

    申请号：US10613914

    申请日：2003-07-03

    发明人： Jerome P. Horwitz ,  Thomas H. Corbett ,  Eduardo Palomino ,  Lisa Polin ,  Stuart T. Hazeldine

    IPC分类号： A01N043/60 ,  A01N043/42 ,  C07D241/36 ,  C07D215/60

    CPC分类号： C07D215/227 ,  C07D241/44

    摘要： The invention provides compounds of the formula: 1 wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.

    摘要翻译： 本发明提供下式的化合物：其中A，X，Y和Z如说明书中所定义。 这些化合物是有效的抗肿瘤剂。 本发明还提供了包含上式化合物或其盐的药物组合物，可用于制备上式化合物的中间体，以及包括将上式化合物或其盐施用于有需要的哺乳动物的治疗方法 。

    Antitumor agents
    75.
    发明申请
    Antitumor agents 有权
    抗肿瘤剂

    公开(公告)号：US20030144321A1

    公开(公告)日：2003-07-31

    申请号：US10210781

    申请日：2002-07-31

    发明人： Jerome P. Horwitz ,  Stuart T. Hazeldine ,  Thomas H. Corbett ,  Lisa Polin

    IPC分类号： C07D215/60 ,  A61K031/47 ,  A61K031/4704

    CPC分类号： C07D215/227

    摘要： The invention provides compounds of formula I: 1 wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.

    摘要翻译： 本发明提供式I化合物：其中Y是F，Cl，Br，甲基或甲氧基; 及其药学上可接受的盐。 这些化合物是有效的抗肿瘤剂。 本发明还提供了包含式I化合物或其盐的药物组合物，可用于制备式I化合物的中间体，以及包括将式I化合物或其盐施用于有需要的哺乳动物的治疗方法。

    4-amino quinolines and naphthyridines and their use as medicines
    79.
    发明授权
    4-amino quinolines and naphthyridines and their use as medicines 失效
    4-氨基喹啉和萘啶并用作药物

    公开(公告)号：US5026711A

    公开(公告)日：1991-06-25

    申请号：US362105

    申请日：1989-06-06

    申请人： Etienne Mendes ,  Jean-Claude Vernieres ,  Peter E. Keane ,  Andre Bachy

    发明人： Etienne Mendes ,  Jean-Claude Vernieres ,  Peter E. Keane ,  Andre Bachy

    IPC分类号： A61K31/435 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P25/20 ,  A61P31/04 ,  A61P37/00 ,  A61P37/08 ,  C07D215/42 ,  C07D215/54 ,  C07D215/60 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056 ,  C07D491/147

    CPC分类号： C07D401/06 ,  C07D215/42 ,  C07D215/54 ,  C07D215/60 ,  C07D471/04 ,  C07D491/04

    摘要： Compounds represented by the general formula: ##STR1## in which R.sub.1 and R.sub.2 are selected from hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl , phenyl or benzyl or R.sub.1 and R.sub.2 form together with the nitrogen atom to which they are attached a C.sub.4 -C.sub.8 saturated heterocycle, R.sub.3 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl or C.sub.7 -C.sub.9 phenyl-alkyl, R.sub.4 is selected from hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.5 and R.sub.6 are selected from hydrogen or halogen, C.sub.1 -C.sub.3 or alkoxy, nitro or trifluoromethyl; Z is selected from OH, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.4 alkyl, benzyl, C.sub.4 -C.sub.6 aryl with or without a heteroatom, or NR.sub.8 R.sub.9, R.sub.8 and R.sub.9 being selected from hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or benzyl; R.sub.10 is selected from hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl; n is 0, 1 or 3, p is 0 or 1 and one of the symbols A, B, C, D represents N and the others CH or A, B, C, D all represent CH and their acid addition salts, and their salts with bases. The compounds are useful in the prevention and treatment of cardiovascular diseases, as anti-allergic drugs, in the prevention and treatment of infectious states, and for the treatment of anxiety.

    摘要翻译： 由以下通式表示的化合物：其中R 1和R 2选自氢，C 1 -C 6烷基或C 2 -C 6烯基，苯基或苄基或R 1和R 2与它们所连接的氮原子一起形成C4 -C8饱和杂环，R3选自氢，C1-C6烷基，苯基或C7-C9苯基 - 烷基，R4选自氢或C1-C4烷基，R5和R6选自氢或卤素，C1-C3或 烷氧基，硝基或三氟甲基; Z选自OH，C 1 -C 6烷氧基，C 1 -C 4烷基，苄基，具有或不具有杂原子的C 4 -C 6芳基，或NR 8 R 9，R 8和R 9选自氢，C 1 -C 4烷基，苯基或苄基; R 10选自氢，C 1 -C 4烷基或苯基; n为0,1或3，p为0或1，符号A，B，C，D中的一个为N，其余CH或A，B，C，D全部为CH及其酸加成盐， 与碱的盐。 该化合物可用于预防和治疗心血管疾病，作为抗过敏药物，预防和治疗感染状态以及治疗焦虑症。