公开(公告)号：US20230094083A1

公开(公告)日：2023-03-30

申请号：US18062601

申请日：2022-12-07

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Valery KRIZHANOVSKY ,  Yossi OVADYA

IPC: C07K16/44 ,  A61P43/00

Abstract: Described herein are anti-human Grp94 antibodies. The antibodies may be used to target senescent cells. Thus, the anti-Grp94 antibodies would be useful in treating diseases and conditions associated with cellular senescence. The anti-Grp94 antibodies could target senescent cells in vivo. Therefore, the anti-Grp94 antibodies could be used to target senescent cells associated with age-related diseases in vivo.

公开(公告)号：US20230063965A1

公开(公告)日：2023-03-02

申请号：US17794268

申请日：2021-01-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony DAHAN ,  Noy COHEN SABAN

IPC: C07K16/28 ,  A61P35/00

Abstract: An article of manufacture is provided. The article of manufacture comprising a first binding moiety which specifically binds a human FcgamaRIIB and blocks interaction with IgG antibodies and a second binding moiety which specifically binds a human PD-L1, wherein the second binding moiety which specifically binds the human PD-L1 is an antibody of a human IgG1 isotype.

公开(公告)号：US20230055651A1

公开(公告)日：2023-02-23

申请号：US17975625

申请日：2022-10-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Anat ARZI ,  Lee SELA ,  Anton PLOTKIN ,  Aharon WEISSBROD ,  Noam SOBEL

IPC: A61M21/02 ,  A61M16/10 ,  A61M15/08

Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.

公开(公告)号：US20230039904A1

公开(公告)日：2023-02-09

申请号：US17958401

申请日：2022-10-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Esther BACHAR-LUSTIG

IPC: A61K35/28 ,  A61K31/675 ,  A61K35/22 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  C12N5/00 ,  A61K31/198 ,  A61K31/255 ,  A61K31/7076 ,  A61P37/06 ,  A61P37/02 ,  A61K31/661 ,  A61K39/395

Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.

公开(公告)号：US20230034320A1

公开(公告)日：2023-02-02

申请号：US17489824

申请日：2021-09-30

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Aviel EVEN ,  Dan EVEN

IPC: C12N15/82

Abstract: Disclosed herein are genetically modified plants expressing multiple animal milk proteins. Further disclosed are vectors for expressing in a plant and parts thereof, multiple mammalian milk proteins; genetically modified and or gene-edited plants having at least one cell expressing and producing at least two recombinant mammalian milk proteins wherein expression may be in a seed, bean, grain, fruit, nut, legume, leaf, stem, root, or portion thereof, the recombinant protein being produced by the plant cell; and a method of producing a food, medicament, cosmetic or blocking composition from the genetically modified or gene-edited plant. Reduction or elimination of seed storage proteins in a cell or cells wherein the milk proteins are expressed, or reduction of plant enzymes that can increase the content of oleic and/or stearic fatty acids and/or reduce the content of saturated fats in the plants or plant products are also disclosed.

公开(公告)号：US20230016954A1

公开(公告)日：2023-01-19

申请号：US17781704

申请日：2020-12-10

Applicant: ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Shani Shenhar-Tsarfaty ,  Shlomo Avraham Berliner ,  Ori Rogowski ,  Eyal Fisher ,  Adi Silberman

IPC: G01N33/569

Abstract: The invention provides assays and methods for diagnosing and treating infectious diseases. The invention relates in some embodiments to urinary biomarkers and their use in the differential diagnosis of bacterial and viral infections. The invention further relates to means for determining and providing correct treatment to infection in a non-invasive manner, while minimizing antibiotic misuse.

公开(公告)号：US20220403043A1

公开(公告)日：2022-12-22

申请号：US17870876

申请日：2022-07-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony DAHAN ,  Ran SALOMON

IPC: C07K16/28 ,  A61P35/00

Abstract: A multispecific antibody is provided. The antibody comprising a first moiety, which binds and activates CD40, a second moiety, which specifically binds a dendritic cell (DC) and a third moiety comprising a modified Fc region of the multispecific antibody for enhancing specificity and affinity of binding to FcγRIIb and uses of same.

公开(公告)号：US11497776B2

公开(公告)日：2022-11-15

申请号：US16508325

申请日：2019-07-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Esther Bachar-Lustig

IPC: A61K35/28 ,  A61K35/17 ,  A61K35/22 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  A61K31/675 ,  A61K35/34 ,  A61K35/36 ,  C12N5/00 ,  A61K31/198 ,  A61K31/255 ,  A61K31/7076 ,  A61P37/06 ,  A61P37/02 ,  A61K31/661 ,  A61K39/395 ,  A61K39/00 ,  A61K35/12

Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.

公开(公告)号：US11437501B2

公开(公告)日：2022-09-06

申请号：US17045892

申请日：2019-04-07

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

Inventor： Yossef Paltiel ,  Ron Naaman ,  Karen Michaeli ,  Eilam Smolinsky

IPC: G11C16/04 ,  H01L29/66 ,  G01N27/414 ,  G11C11/02 ,  H01L29/205 ,  H01L29/778 ,  H01L43/06 ,  H01L29/20

Abstract: In a technique for inducing local electric field controlled magnetization, despite the absence of magnetic components, there is provided a novel heterostructure, a semiconductor device thereof, or an array of semiconductor devices. The heterostructure includes a semiconductor substrate carrying a plurality of layers forming at least one heterojunction and hosting a two-dimensional electron gas layer when one of the layer of the plurality of layers is bounded to an interacting layer being a chiral or a biological macromolecule assembly.

公开(公告)号：US11385242B2

公开(公告)日：2022-07-12

申请号：US15744532

申请日：2016-07-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Meir Shinitzky ,  Ludmila Schechtman

IPC: G01N33/68 ,  C07K14/47 ,  C07K7/04

Abstract: Provided is a composition including a combination of at least one short peptide and at least one peptide dimer, in defined ratio, to which autoantibodies found in elevated levels in schizophrenic patients bind.