公开(公告)号：US11897968B2

公开(公告)日：2024-02-13

申请号：US17118921

申请日：2020-12-11

Applicant: Alector LLC

Inventor： Seung-Joo Lee ,  Spencer Liang ,  Angie Yee ,  Marina Roell ,  Arnon Rosenthal

IPC: C07K16/40 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK or human MerTK, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20230183341A1

公开(公告)日：2023-06-15

申请号：US17916728

申请日：2021-04-02

Applicant: Alector LLC

Inventor： Robert PAUL ,  Michael F. WARD ,  Hua LONG ,  Omer Rizwan SIDDIQUI ,  Arnon ROSENTHAL ,  Felix Leejia YEH ,  Sam JACKSON

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a TREM2 protein, e.g., human TREM2, for use in treating and/or delaying progression of a disease or injury in an individual in need thereof.

公开(公告)号：US20230126400A1

公开(公告)日：2023-04-27

申请号：US17821006

申请日：2022-08-19

Applicant: Alector LLC

Inventor： Philip KONG ,  Herve RHINN ,  Tina SCHWABE ,  Angie YEE ,  Ilaria TASSI ,  Muhammad Abbas ALHAWAGRI ,  Arnon ROSENTHAL

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc.. that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230121869A1

公开(公告)日：2023-04-20

申请号：US17931757

申请日：2022-09-13

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220348656A1

公开(公告)日：2022-11-03

申请号：US17836707

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Michael KURNELLAS ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220251190A1

公开(公告)日：2022-08-11

申请号：US17459835

申请日：2021-08-27

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Francesca AVOGADRI-CONNORS ,  Seung-Joo LEE ,  William MONTEITH ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11339223B2

公开(公告)日：2022-05-24

申请号：US16058817

申请日：2018-08-08

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11319373B2

公开(公告)日：2022-05-03

申请号：US16421692

申请日：2019-05-24

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Wei-Hsien Ho ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/40 ,  C07K16/42 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPA polypeptide, e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11208488B2

公开(公告)日：2021-12-28

申请号：US16134830

申请日：2018-09-18

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11186645B2

公开(公告)日：2021-11-30

申请号：US16741658

申请日：2020-01-13

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.