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公开(公告)号：US11744888B2
公开(公告)日：2023-09-05
申请号：US17643293
申请日：2021-12-08
IPC分类号： A61K39/215 , A61P31/14 , C12N7/00 , A61K39/00
CPC分类号： A61K39/215 , A61P31/14 , C12N7/00 , A61K2039/5256 , A61K2039/552 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071
摘要： The present invention relates i.a. to a 4/91 IBV (infectious bronchitis virus) encoding for a heterologous S (spike) protein or fragment thereof. Further, the present invention relates to an immunogenic composition comprising said 4/91 IBV encoding for a heterologous S (spike) protein or fragment thereof. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.
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公开(公告)号：US11730806B2
公开(公告)日：2023-08-22
申请号：US16879471
申请日：2020-05-20
发明人： Andrea J. Headrick Starks , Fuad Tawfiq Haddadin , Gregory Brian Haiwick , Merrill Lynn Schaeffer , Curtis Robert Edwards
CPC分类号： A61K39/23 , A61K39/12 , A61P31/14 , A61P31/20 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C12N2750/14322 , C12N2770/10034
摘要： The present invention relates to a porcine parvovirus and porcine reproductive and respiratory syndrome virus vaccine for protecting a subject, preferably swine, against diseases associated with porcine parvovirus and porcine reproductive and respiratory syndrome virus. The present invention further relates to methods of producing immunogenic compositions as well as such immunogenic compositions exhibiting reduced virucidal activity.
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公开(公告)号：US11696947B2
公开(公告)日：2023-07-11
申请号：US16665465
申请日：2019-10-28
IPC分类号： A61K39/215 , C12N7/00 , A61P31/14 , A61K39/00
CPC分类号： A61K39/215 , A61P31/14 , C12N7/00 , A61K2039/5256 , A61K2039/552 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071
摘要： The present invention relates i.a. to an H52 IBV (infectious bronchitis virus) encoding for a heterologous S (spike) protein or fragment thereof. Further, the present invention relates to an immunogenic composition comprising said H52 IBV encoding for a heterologous S (spike) protein or fragment thereof. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.
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84.发明公开公开(公告)号：US20230175017A1
公开(公告)日：2023-06-08
申请号：US17812732
申请日：2022-07-15
发明人： Michel Bublot , Teshome Mebatsion , Joyce Pritchard , Perry Linz , Aemro Kassa
IPC分类号： C12N15/869 , A61K39/12 , A61K39/155 , A61K39/245 , A61K39/295 , C07K14/03 , C07K14/08 , C12N7/00
CPC分类号： C12N15/869 , A61K39/12 , A61K39/155 , A61K39/245 , A61K39/295 , C07K14/03 , C07K14/08 , C12N7/00 , C12N2760/16163 , C12N2710/16363 , C12N2760/18163 , C12N2710/16334 , C12N2710/16343 , C12N2720/10034 , C12N2760/18134 , C12N2830/20 , C12N2830/50 , C12N2840/203 , C12N2710/16311
摘要： The invention relates to a bonding and forming device for an inner box of a paper box and surface paper. The bonding and forming device comprises a stand, a lifting platform, a paper box inner support member, a flanging pressing plate, an ejector pin, a left hairbrush, a right hairbrush, a first pushing part, a front hairbrush, a rear hairbrush and a second pushing part and also comprises a driving device, a first control device a second control device, a third control device, a fourth control device and a fifth control device, wherein the driving device is used for driving the ejector pin to rise or fall; the first control device is used for controlling the paper box inner support member to rise or fall; the second control device is used for controlling the left hairbrush and the right hairbrush to stretch; the third control device is used for controlling the first pushing part to stretch; the fourth control device is used for controlling the front hairbrush and the rear hairbrush to stretch; the fifth control device is used for controlling the second pushing part to stretch; an inhibiting device is arranged between the first control device and the driving device; and the paper box inner support member and the flanging pressing plate are respectively provided with a through hole for the ejector pin to pass through. By adopting the technical scheme, according to the bonding and forming device for the inner box of the paper box and the surface paper, provided by the invention, the inner box and other surfaces of the surface paper can be automatically bonded to be formed after a bottom plate of the inner box and the bottom surface of the surface paper are bonded. The degree of automation is high and the production efficiency is high.
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公开(公告)号：US20220226822A1
公开(公告)日：2022-07-21
申请号：US17715131
申请日：2022-04-07
发明人： Matthias KRONSBEIN , Lutz WEBER , Hannah SCHMOLKE
IPC分类号： B01L3/00
摘要： A cartridge for analyzing a biological sample, wherein the cartridge includes a fluid system having a plurality of channels and at least one valve, wherein the valve is covered on the outside by a cover, and wherein the valve is configured to be actuated by deforming a wall of the valve.
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公开(公告)号：US20220226290A1
公开(公告)日：2022-07-21
申请号：US17596356
申请日：2020-04-30
发明人： Anne Michelle TRAAS , Amanda ERICKSON COLEMAN , Bianca Natália FERREIRA DE MOURA LOURENCO , Kate Elizabeth CREEVY , Scott Alan Brown
IPC分类号： A61K31/4184 , A61P9/12 , A61K45/06
摘要： The present invention relates to telmisartan or a pharmaceutically acceptable salt thereof as a medicament for the treatment of hypertension in dogs, wherein the therapeutically effective amount of telmisartan is administered in a daily dosage amount that is varied over a treatment period.
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公开(公告)号：US20220213299A1
公开(公告)日：2022-07-07
申请号：US17701009
申请日：2022-03-22
摘要： An inhaler, particularly for a horse, having a reservoir for dispensing a medicament preparation held under excess pressure, with a discharge nozzle for forming an aerosol of the medicament preparation and with a chamber for holding and temporarily storing the aerosol, which is located on the outlet side, a respiratory orifice adapter for a respiratory orifice, particularly a nostril, while according to a first aspect the reservoir is secured in position, at least in the axial direction, according to a second aspect the discharge nozzle has a direction of discharge which is inclined by more than 5° and less than 50° relative to a central axis of the reservoir or a direction of actuation for dispensing the aerosol, and according to a third aspect, the reservoir has a dispensing valve which is arranged at the top in the position of use of the inhaler.
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公开(公告)号：US11298325B2
公开(公告)日：2022-04-12
申请号：US17097039
申请日：2020-11-13
发明人： Péter Laczay
IPC分类号： A61K9/20 , A61K9/50 , A61K31/501 , A61K31/341 , A61K31/55 , A61K9/16 , A61K45/06 , A61K31/585 , A61K31/635
摘要： A method for the preparation of a composition includes dispersing particulate pimobendan in a molten carrier matrix to form particles coated with the carrier matrix, where the molten carrier matrix includes one or more pharmaceutically acceptable carriers selected from a polyglycolized glyceride, a polyethylene glycol, and combinations thereof, atomizing the dispersion of coated particles, and cooling and collecting the coated particles from the atomized dispersion.
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公开(公告)号：US11291994B2
公开(公告)日：2022-04-05
申请号：US16871079
申请日：2020-05-11
摘要： A cartridge, an analysis system and a method for analyzing, in particular, a biological sample, wherein a first group having one or more valves and a second group having one or more valves can be or are actuated from different sides of the cartridge.
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公开(公告)号：US11287434B2
公开(公告)日：2022-03-29
申请号：US15725352
申请日：2017-10-05
发明人： Axel Niemeyer , Hannah Schmolke , Heinz Schoeder , Kai Wuerz
摘要： An analysis system and a method for testing a biological sample, wherein an operating instrument is provided which preferably can be separated from an analysis device with respect to a data connection and/or wirelessly connected to the analysis device.
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