公开(公告)号：US11370890B2

公开(公告)日：2022-06-28

申请号：US17038061

申请日：2020-09-30

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS ,  UNIVERSITE DE POITIERS ,  VALAGRO CARBONE RENOUVELABLE POITOU-CHARENTES

发明人： Thierry Ferreira ,  Frederic Bataille ,  Cedric Dever ,  Jacques Barbier

IPC分类号： C08J3/00 ,  C08J3/20 ,  C12N9/14 ,  C12N11/04 ,  C08L67/04 ,  C12N9/20 ,  C12N9/58 ,  C12N11/18 ,  C12N11/098 ,  C12N11/096 ,  C08K5/00

摘要： The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.

公开(公告)号：US20220193252A1

公开(公告)日：2022-06-23

申请号：US17559140

申请日：2021-12-22

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE DE NANTES ,  CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

发明人： Mathieu MEVEL ,  David DENIAUD ,  Eduard AYUSO

IPC分类号： A61K47/69 ,  A61K48/00 ,  A61K49/18 ,  C12N7/00

摘要： The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety.
Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats. The present invention further relates to a method for chemically coupling an Adeno-Associated Virus (AAV) vector particle with at least one ligand L and to a Recombinant Adeno-Associated Virus (rAAV) vector particle obtained by said method as well as a pharmaceutical composition comprising it and their corresponding medical use.

公开(公告)号：US11357816B2

公开(公告)日：2022-06-14

申请号：US17252573

申请日：2019-06-17

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  SORBONNE UNIVERSITE ,  ECOLE NORMALE SUPERIEURE ,  COLLEGE DE FRANCE

发明人： Jean-Maurice Mallet ,  Solange Lavielle ,  Rodrigue Marquant ,  Alain Prochiantz ,  Ariel Di Nardo ,  Damien Testa

IPC分类号： A61K38/00 ,  A61K38/04 ,  C07K14/47

摘要： The invention relates to new compounds that mimic Glycosaminoglycans and are able to control interaction between Glycosaminoglycans with their effector molecules. The compounds of the invention are peptides and are able to prevent or reduce the binding of at least one effector molecule with at least one glycosaminoglycan. The compounds according to the invention can be used as drug, in particular for the stimulation of the neurogenesis and more generally to treat nervous system related pathologies.

公开(公告)号：US11357778B2

公开(公告)日：2022-06-14

申请号：US16662126

申请日：2019-10-24

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LE RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS ,  UNIVERSITE DE PARIS ,  IMAGINE

发明人： Laurence Legeai-Mallet ,  Arnold Munnich ,  Patricia Busca ,  Florent Barbault

IPC分类号： A61K31/497 ,  A61K31/506 ,  B29C48/00 ,  C08J5/18 ,  C08L51/04 ,  B32B27/30 ,  C08L25/06 ,  B29K25/00 ,  B29K35/00 ,  B29K201/00 ,  B29L31/00

摘要： The present invention relates to the treatment or prevention of skeletal disorders, at particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

公开(公告)号：US11344372B2

公开(公告)日：2022-05-31

申请号：US17334566

申请日：2021-05-28

申请人： SpineGuard ,  Sorbonne Universite ,  INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Centre National de la Recherche Scientifique—CNRS

发明人： Maurice Bourlion ,  Olivier Frezal ,  Guillaume Morel ,  Stephane Bette ,  Thibault Chandanson ,  Florian Richer ,  Valentin Kerspern

IPC分类号： A61B34/10 ,  A61B34/20 ,  A61B34/30 ,  A61B17/16 ,  A61B17/00

摘要： Systems, instruments, and methods are provided verifying that a robotic surgery is being performed in accordance with a surgical plan, wherein a surgical tool having a sensor outputs a data signal that enables the trajectory of the surgical tool to be displayed as an overlay on an image of an anatomical portion of a patient and a visual or audible signal that confirms the surgical tool is penetrating the anatomical portion in accordance with the surgical plan and/or that issues an alert indicating that the surgical tool is not being inserted into the anatomical portion according to the surgical plan.

公开(公告)号：US20220162305A1

公开(公告)日：2022-05-26

申请号：US17440836

申请日：2020-03-20

申请人： IMCHECK THERAPEUTICS SAS ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  UNIVERSITÉ D'AIX-MARSEILLE

发明人： Etienne FOUCHER ,  Carla CANO ,  Kieu Suong LE ,  Christine PASERO ,  Daniel OLIVE

IPC分类号： C07K16/28

摘要： The present invention relates to antibodies having specificity for BTN2A and uses thereof, in particular for the treatment of cancer.

公开(公告)号：US20220160861A1

公开(公告)日：2022-05-26

申请号：US17552256

申请日：2021-12-15

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE PARIS DIDEROT PARIS 7 ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Philippe VERBEKE ,  Colette KANELLOPOULOS

IPC分类号： A61K39/118 ,  A61P31/04 ,  G01N33/569

摘要： The invention relates to vaccine compositions for treating and/or preventing infections by a bacterium of the Chlamydiaceae family, said compositions comprising bacteria of the Chlamydiaceae family, which have been previously treated by at least one peptidoglycan inhibitor, or extracts of said treated bacteria.

公开(公告)号：US20220151780A1

公开(公告)日：2022-05-19

申请号：US17275428

申请日：2019-09-13

申请人： UNIVERSITE TECHNOLOGIE DE COMPIEGNE ,  UNIVERSITE PARIS EST CRETEIL VAL DE MARNE ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Anne-Virginie SALSAC ,  Adrien LAPERROUSAZ ,  Eric BERGOEND ,  Jean-Paul COUETIL

IPC分类号： A61F2/24

摘要： Implant (10) for a heart valve comprising two leaflets, particularly a mitral valve (MV), the implant (10) comprising: a clamp (11) comprising a body (13) and a jaw (14) rotationally hinged with the body (13) to pivot between an open position and a closed position in which the body (13) and the jaw (14) are able to clamp a first leaflet among the heart valve leaflets, so as to attach the implant (10) onto the first leaflet, a movement device (41, 42) comprising a pusher element (41), the movement device being configured to move the jaw (14) relative to the body (13) from the open position to the closed position or vice versa, when the pusher element (41) is pushed by a rod (101), and a balloon (12) attached to the clamp (11) and configured to close at least partially an open portion (O1) remaining between the heart valve (MV) leaflets during systole, when the implant (10) is attached to the first leaflet, so as to limit a reflux of blood through said open portion (O1) remaining during systole.

公开(公告)号：US20220131624A1

公开(公告)日：2022-04-28

申请号：US17571986

申请日：2022-01-10

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  UNIVERSITE PARIS DIDEROT - PARIS 7

发明人： Mathias Fink ,  Geoffroy Lerosey ,  Matthieu Dupre ,  Nadége Kaina

IPC分类号： H04B17/309 ,  H04W4/80 ,  H01Q3/46 ,  H01Q21/00 ,  H01Q3/44 ,  H04L5/00

摘要： A wave shaping device which comprises a tunable impedance surface and a controller connected to the surface in order to control its impedance. The shaping device further comprises a transmission module for receiving a pilot signal used to control the impedance of the surface.

公开(公告)号：US20220125875A1

公开(公告)日：2022-04-28

申请号：US17422737

申请日：2021-01-20

申请人： INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： Saaid SAFIEDDINE ,  Christine PETIT

IPC分类号： A61K38/17 ,  A61P27/16 ,  C12N15/86

摘要： The present inventors report here, in the DFNB9 mouse model (OTOF knock-out mice), the first proof-of-principle that cochlear delivery of a fragmented cDNA via a dual-AAV vector approach can effectively and long-lastingly correct the profound deafness phenotype of these mice when administered well after their auditory system has matured (P30). The present invention therefore concerns a vector system that allows the expression of the full-length Otoferlin polypeptide, or of a functional fragment thereof, in inner hair cells, for use for treating patients suffering from DFNB9 deafness or preventing DFNB9 deafness in patients having DFNB9 mutations, wherein said patients are patients having a developed and mature auditory system, such as new born babies, toddlers, infants, teenagers or adults.