公开(公告)号：US10667870B2

公开(公告)日：2020-06-02

申请号：US15735907

申请日：2016-06-10

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Venkataramanan Krishnaswamy ,  Richard J. Barth, Jr. ,  Keith D. Paulsen

IPC: G06K9/00 ,  A61B34/20 ,  A61B17/34 ,  A61B17/00

Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.

公开(公告)号：US20200155488A1

公开(公告)日：2020-05-21

申请号：US16742600

申请日：2020-01-14

Applicant: Io Therapeutics, Inc. ,  Trustees of Dartmouth College

Inventor： Roshantha A. Chandraratna ,  Ethan Dmitrovsky ,  Elizabeth Nowak ,  Randolph Noelle

IPC: A61K31/192 ,  A61K9/00 ,  A61K31/4704 ,  A61K31/47 ,  A61K31/343 ,  A61K31/353 ,  A61K31/201 ,  A61K31/216

Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.

公开(公告)号：US10608632B2

公开(公告)日：2020-03-31

申请号：US16163201

申请日：2018-10-17

Applicant: Trustees of Dartmouth College ,  Carnegie Mellon University

Inventor： Xing-Dong Yang ,  Jun Gong ,  Yang Zhang ,  Xia Zhou

IPC: H03K17/94 ,  G06F1/16 ,  G06F3/01 ,  G06N20/00 ,  G06F3/03

Abstract: An infrared (IR)-based gesture sensing and detection system that includes at least one IR sensor for sensing micro gestures of one or more heat-radiating bodies made within a gesture-sensing region located proximate to the IR sensor. Each unique micro gesture may be used as a control gesture for controlling one or more controllable devices. Non-limiting examples of controllable devices include smart wearable device, handheld computing devices, and smart appliances, among many others. In some embodiments, each IR sensor is a passive IR sensor based on a pyroelectric material, and the IR-based gesture sensing and detection system is configured to consume minimal power to operate.

公开(公告)号：US20200093902A1

公开(公告)日：2020-03-26

申请号：US16669552

申请日：2019-10-31

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  KING'S COLLEGE LONDON

Inventor： Randolph J. NOELLE ,  Sabrina CEERAZ ,  Isabelle LeMERCIER ,  Elizabeth NOWAK ,  Janet LINES ,  Li WANG ,  Mark SPALLER

IPC: A61K39/00 ,  C07K16/28 ,  G01N33/566 ,  C07K7/08 ,  A61K45/06

Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

公开(公告)号：US20200046264A1

公开(公告)日：2020-02-13

申请号：US16596123

申请日：2019-10-08

Applicant: Trustees of Dartmouth College

Inventor： Ryan Chapman ,  Douglas Wayne Van Citters ,  Wayne Edward Moschetti ,  John-Erik Bell

IPC: A61B5/11 ,  A61B5/00 ,  A61B5/107

Abstract: Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a first side of the joint and a second set of sensors may sense accelerations of the second body portion located on a second opposing side of the joint. The acceleration data may then be used to compute the relative motion of the first and second body portions to determine movement of the joint. This joint movement may then be used to determine one or more range of motion movement metrics which are output for viewing by a subject or medical practitioner.

公开(公告)号：US20190393406A1

公开(公告)日：2019-12-26

申请号：US16481023

申请日：2018-01-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Zi CHEN ,  John X.J. ZHANG ,  Lin DONG ,  Zhe XU

IPC: H01L41/113 ,  H01L41/193 ,  H02N2/18 ,  A61N1/378

Abstract: A piezoelectric energy harvester has a layered structure comprising a first electrode, a polymeric piezoelectric material, and a second electrode, the layered structure coupled to receive mechanical stress from the environment, and the first and second electrode electrically coupled to a power converter. The power converter is adapted to charge an energy storage device selected from a capacitor and a battery. The method of harvesting energy from the environment includes providing a piezoelectric device comprising a layer of a polymeric piezoelectric material disposed between a first and a second electrode; coupling mechanical stress derived from an environment to the piezoelectric device; and coupling electrical energy from the piezoelectric device.

公开(公告)号：US20190365475A1

公开(公告)日：2019-12-05

申请号：US15735907

申请日：2016-06-10

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Venkataramanan KRISHNASWAMY ,  Richard J. BARTH, Jr. ,  Keith D. PAULSEN

IPC: A61B34/20

Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.

公开(公告)号：US20190284636A1

公开(公告)日：2019-09-19

申请号：US16345158

申请日：2017-10-26

Applicant: BROWN UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF KANSAS ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Karl Kelsey ,  John Wiencke ,  Devin Koestler ,  Brock Christensen

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/6881 ,  G16H50/20 ,  G06F17/18

Abstract: Ratio of neutrophils to lymphocytes (NLR) is here associated with immune suppression and decreased survival times in multiple solid tumors. Based on immune cell-specific DMRs and validated cell deconvolution algorithms, the NLR in blood from glioma patients was estimated and glioma patients had elevated mdNLR scores compared to controls. The patient mdNLR scores were increased in patients with grade IV tumors compared to grade II/III. High mdNLR scores were associated with shorter survival. Candidate single (myeloid-associated) gene loci that were highly correlated with the mdNLR were identified. Single myeloid differentiation loci provide a simpler and cheaper alternative to the mdNLR, which requires complex array data. Immunomethylomics are useful and more convenient than conventional cell analysis in profiling glioma risk and survival.

公开(公告)号：US10377716B2

公开(公告)日：2019-08-13

申请号：US15785193

申请日：2017-10-16

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  C07D209/12 ,  C07D215/14 ,  A23L33/10

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

公开(公告)号：US10368788B2

公开(公告)日：2019-08-06

申请号：US15216675

申请日：2016-07-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Axel Scherer ,  Meisam Honarvar Nazari ,  Muhammad Mujeeb-U-Rahman ,  Mehmet Sencan ,  Arti Gaur

IPC: A61M5/142 ,  A61M5/172 ,  A61B5/1473 ,  A61B17/34 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/07

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.