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    Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
    82.
    发明授权
    Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device 失效
    将抗血栓形成材料共价固定在医疗装置上的涂层中的方法

    公开(公告)号：US07682669B1

    公开(公告)日：2010-03-23

    申请号：US09918365

    申请日：2001-07-30

    Applicant: Eugene T. Michal ,  Ni Ding ,  Christopher J. Buchko

    Inventor： Eugene T. Michal ,  Ni Ding ,  Christopher J. Buchko

    IPC: B05D3/06

    CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L33/0029 ,  A61L33/0088 ,  A61L2300/42 ,  A61L2420/08

    Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.

    Abstract translation: 本发明涉及一种具有用于固定抗血栓形成材料如肝素的聚合底涂层的医疗装置。 粘合涂层由各种化学官能团组成，它们是稳定的并允许将抗血栓形成材料固定在其上。 还提供了将抗凝血栓塞材料固定在医疗装置表面上的底涂层内的方法。

    Heparin Prodrugs and Drug Delivery Stents Formed Therefrom
    84.
    发明申请
    Heparin Prodrugs and Drug Delivery Stents Formed Therefrom 审中-公开
    肝素前药和药物输送支架

    公开(公告)号：US20090258029A1

    公开(公告)日：2009-10-15

    申请号：US12489205

    申请日：2009-06-22

    Applicant: Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    Inventor： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

    IPC: A61K39/44 ,  C08B37/10 ,  C07K17/08 ,  C08L39/06 ,  A61P7/02

    CPC classification number: A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

    Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    Abstract translation: 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

    POLYMERS CONTAINING SILOXANE MONOMERS
    86.
    发明申请
    POLYMERS CONTAINING SILOXANE MONOMERS 有权
    含硅氧烷单体的聚合物

    公开(公告)号：US20080262606A1

    公开(公告)日：2008-10-23

    申请号：US12135921

    申请日：2008-06-09

    Applicant: Ni Ding ,  Stephen D. Pacetti

    Inventor： Ni Ding ,  Stephen D. Pacetti

    IPC: A61F2/82 ,  C08G77/04 ,  A61F2/00

    CPC classification number: C08G77/442 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L83/04

    Abstract: A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    Abstract translation: 提供了作为柔性单体和强度单体的硅氧烷的聚合物。 还提供了一种聚合物共混物，其包含由硅氧烷单体和强度单体形成的聚合物和另一种生物相容性聚合物。 本文所述的生物相容性聚合物或聚合物共混物和任选的生物活性剂可以在可植入装置如药物递送支架上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。

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