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    Methods and systems for adaptive pedestrian inertial navigation
    83.
    发明授权
    Methods and systems for adaptive pedestrian inertial navigation 有权

    公开(公告)号：US12215975B2

    公开(公告)日：2025-02-04

    申请号：US17395706

    申请日：2021-08-06

    Applicant: The Regents of the University of California

    Inventor： Yusheng Wang ,  Andrei M. Shkel

    IPC: G01C21/16 ,  A61B5/11 ,  G01C21/20 ,  G01C22/00

    Abstract: Processes and systems for adaptive pedestrian inertial navigation are provided. Configurations can adjust to various navigation scenarios, including different floor types and different gait paces. A combination of IMU data partition, principal component analysis (PCA), and artificial neural network may be used to perform the floor type detection. Floor type results may be used in the multiple-model extended Kalman filter. In each extended Kalman filter, an adaptive threshold is used for the stance phase detection to enable the detector to adjust to gait frequency without tuning design parameters during navigation. A floor type classification of high accuracy is demonstrated, and the position error in a velocity-changing navigation system using adaptive threshold is reduced.

    METHODS AND COMPOSITIONS FOR PREPARING AN ARRAYED LIBRARY OF CELLS
    84.
    发明申请
    METHODS AND COMPOSITIONS FOR PREPARING AN ARRAYED LIBRARY OF CELLS 有权

    公开(公告)号：US20250034554A1

    公开(公告)日：2025-01-30

    申请号：US18782679

    申请日：2024-07-24

    Applicant: The Regents of the University of California

    Inventor： Amy Yi-Tyng Chang ,  Eric D. Chow ,  Brandon Kwan-Leong

    IPC: C12N15/10 ,  C12M1/12 ,  C12M1/30 ,  C12M1/36 ,  C40B60/00 ,  G01N35/00 ,  G01N35/10

    Abstract: Provided are methods and compositions for creating an arrayed library of cells. In particular, the methods and compositions provided herein improve the selection and transfer of cells by reducing contamination, increasing throughput, and improving consistency of transfer. Such methods and compositions include automated colony selection employing a solid barrier mounted on an automated apparatus for automatic handling of one or more pick tools. The solid barrier is configured to prevent undesired transfer of cells from a pick tool into the destination receptacle. Such methods and compositions also include acoustic transfer of cells in a high-density media by an acoustic liquid handler. The methods and compositions further include pooling the cells using a bitcode sample pooling scheme for high-throughput sequencing and deconvoluting the obtained nucleic acid sequences to identify the cells from which the sequences originated.

    ANTIBODY CHEMICALLY INDUCED DIMERIZER (ABCID) AS MOLECULAR SWITCHES FOR REGULATING CELLULAR THERAPIES
    85.
    发明申请
    ANTIBODY CHEMICALLY INDUCED DIMERIZER (ABCID) AS MOLECULAR SWITCHES FOR REGULATING CELLULAR THERAPIES 有权

    公开(公告)号：US20250034251A1

    公开(公告)日：2025-01-30

    申请号：US18437999

    申请日：2024-02-09

    Applicant: The Regents of the University of California

    Inventor： James A. WELLS ,  Zachary B. HILL ,  Alexander J. MARTINKO

    IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395

    Abstract: Chemically induced dimerizers (AbCIDs) have emerged as one of the most powerful tools to artificially regulate signaling pathways in cells; however, no facile method to identify or design these systems currently exists. The present invention provides a methodology to rapidly generate antibody-based chemically induced dimerizers (AbCIDs) from known small-molecule-protein complexes by selecting for synthetic antibodies that recognize the chemical epitope created by the bound small molecule. Success of this strategy is demonstrated by generating ten chemically-inducible antibodies against the BCL-xL/ABT-737 complex. Three of the antibodies are highly selective for the BCL-xL/ABT-737 complex over BCL-xL alone. Two exemplary important cellular applications of AbCIDs are demonstrated by applying them intracellularly to induce CRISPRa-mediated gene expression and extracellularly to regulate CAR T-cell activation with the small molecule, ABT-737. ABT-737 is not toxic at the concentrations used to activate AbCIDs in cells. AbCIDs provided by this invention are new and orthogonal AbCIDs, expanding the limited toolbox of available CIDs.

    SIRPALPHA SWITCH RECEPTORS
    86.
    发明申请
    SIRPALPHA SWITCH RECEPTORS 有权

    公开(公告)号：US20250032544A1

    公开(公告)日：2025-01-30

    申请号：US18716906

    申请日：2022-12-07

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Tobias Deuse

    IPC: A61K35/17 ,  A61K39/00 ,  A61P35/02 ,  C07K14/705

    Abstract: The invention provides recombinant CD47 engager receptor proteins comprising an intracellular domain that enhances an immune response in a cell when the CD47 engager receptor protein binds to CD47 on a target cell. The invention also provides cells comprising the CD47 engager receptor proteins. The CD47 engager receptor protein may be a switched Signal Regulatory Protein Alpha (SIRPα) receptor (SIRPα switch receptors) and cells that comprise them (SIRPα switch cells). SIRPα switch receptors recognize CD47 on target tumor cells and transmit an intracellular signal within the SIRPα switch cells that upregulates natural killer cell (NK), T cell, and macrophage activity. The result is increased tumor cell killing.

    Method to control the relaxation of thick films on lattice-mismatched substrates
    89.
    发明授权
    Method to control the relaxation of thick films on lattice-mismatched substrates 有权

    公开(公告)号：US12211955B2

    公开(公告)日：2025-01-28

    申请号：US17576716

    申请日：2022-01-14

    Applicant: The Regents of the University of California

    Inventor： Kamruzzaman Khan ,  Elaheh Ahmadi ,  Stacia Keller ,  Christian Wurm ,  Umesh K. Mishra

    IPC: H01L33/32 ,  H01L33/00

    Abstract: A substrate comprising a III-N base layer comprising a first portion and a second portion, the first portion of the III-N base layer having a first natural lattice constant and a first dislocation density; and a first III-N layer having a second natural lattice constant and a second dislocation density on the III-N base layer, the first III-N layer having a thickness greater than 10 nm. An indium fractional composition of the first III-N layer is greater than 0.1; the second natural lattice constant is at least 1% greater than the first natural lattice constant; a strain-induced lattice constant of the first III-N layer is greater than 1.0055 times the first natural lattice constant; and the second dislocation density is less than 1.5 times the first dislocation density.

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