公开(公告)号：US20140343290A1

公开(公告)日：2014-11-20

申请号：US14235127

申请日：2012-07-25

Applicant: Rakesh Kumar Singh ,  Nagaraju Gottumukkala ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad ,  Sudershan Kumar Arora

Inventor： Rakesh Kumar Singh ,  Nagaraju Gottumukkala ,  Mahavir Singh Khanna ,  Rajesh Kumar Thaper ,  Mohan Prasad ,  Sudershan Kumar Arora

IPC: C07D213/42

CPC classification number: C07D213/42

Abstract: The present invention relates to an improved process for the preparation of atazanavir bisulfate, an inhibitor of retroviral aspartate protease. The process of the present invention comprises conversion of 1,1-dimethylethyl[(2S,3R)-4-chloro-3-hydroxy-phenylbutan-2-yl]carbamate (Formula II) into 1-[4-(pyridine-2-yl)-phenyl]-4(S)-5 hydroxy-2-N-tert-butoxycarbonylamino-5(S)—N—(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane (Formula VII) without isolating intermediate compounds formed therein, followed by its subsequent conversion to atazanavir or its bisulfate salt.

Abstract translation: 本发明涉及一种制备逆转录病毒天冬氨酸蛋白酶抑制剂阿扎那韦硫酸氢盐的改进方法。 本发明的方法包括将[（2S，3R）-4-氯-3-羟基 - 苯基丁-2-基]氨基甲酸酯（式II）的1,1-二甲基乙基酯转化为1- [4-（吡啶-2 - 基） - 苯基] -4（S）-5-羟基-2-N-叔丁氧基羰基氨基-5（S）-N-（N-甲氧基羰基 - （L） - 叔 - 亮氨酰基）氨基-6-苯基-2 （式Ⅶ），而不分离其中形成的中间体化合物，随后转化成阿扎那韦或其硫酸氢盐。

公开(公告)号：US08861842B2

公开(公告)日：2014-10-14

申请号：US13022118

申请日：2011-02-07

Applicant: Sang-Hack Jung ,  Mayank Bansal ,  Bogdan Calin Mihai Matei ,  Jayan Eledath ,  Harpreet Singh Sawhney ,  Rakesh Kumar ,  Raia Hadsell

Inventor： Sang-Hack Jung ,  Mayank Bansal ,  Bogdan Calin Mihai Matei ,  Jayan Eledath ,  Harpreet Singh Sawhney ,  Rakesh Kumar ,  Raia Hadsell

IPC: G06K9/00

CPC classification number: G06K9/00805 ,  G06K9/00369

Abstract: A computer implemented method for detecting the presence of one or more pedestrians in the vicinity of the vehicle is disclosed. Imagery of a scene is received from at least one image capturing device. A depth map is derived from the imagery. A plurality of pedestrian candidate regions of interest (ROIs) is detected from the depth map by matching each of the plurality of ROIs with a 3D human shape model. At least a portion of the candidate ROIs is classified by employing a cascade of classifiers tuned for a plurality of depth bands and trained on a filtered representation of data within the portion of candidate ROIs to determine whether at least one pedestrian is proximal to the vehicle.

Abstract translation: 公开了一种用于检测车辆附近的一个或多个行人的存在的计算机实现方法。 从至少一个图像捕获装置接收场景的图像。 从图像中导出深度图。 通过将多个ROI中的每一个与3D人体形状模型进行匹配，从深度图检测多个行人候选区域（ROI）。 候选ROI的至少一部分通过采用针对多个深度带调谐的分级器级联进行分类，并且针对候选ROI部分内的数据的滤波表示进行训练，以确定至少一个行人是否靠近车辆。

公开(公告)号：US08835450B2

公开(公告)日：2014-09-16

申请号：US13500241

申请日：2010-10-08

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

IPC: A61K31/506 ,  A61P35/00 ,  A61P35/02 ,  A61K45/06 ,  A61K31/4155

CPC classification number: A61K31/506 ,  A61K31/4155 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and N-{(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基） 吡啶-2-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐和N - {（1S）-2-氨基-1 - [（3,4-二氟苯基）甲基]乙基} -4-（4-氯-1-甲基-1H-吡唑-5-基）-2-呋喃甲酰胺或其药学上可接受的盐给有需要的人。

公开(公告)号：US08805840B1

公开(公告)日：2014-08-12

申请号：US12772166

申请日：2010-04-30

Applicant: Ashutosh Joshi ,  Martin Betz ,  Rajiv Arora ,  Rakesh Kumar Srivastava ,  David Cooke

Inventor： Ashutosh Joshi ,  Martin Betz ,  Rajiv Arora ,  Rakesh Kumar Srivastava ,  David Cooke

IPC: G06F7/00 ,  G06F17/30

CPC classification number: G06F17/30864 ,  G06F17/30707

Abstract: Some embodiments provide a method for evaluating a content segment for relevancy to several of categories. The method retrieves the content segment. For each of the several categories, the method determines the relevancy of the content segment to the category by using a scoring model for the category. The scoring model accounts for (i) the presence of key word sets in the content segment and (ii) the context of the key word sets in the content segment. For each of the several categories, the method tags the content segment when the content segment is determined as relevant to the category.

Abstract translation: 一些实施例提供了用于评估与几个类别相关的内容段的方法。 该方法检索内容段。 对于几个类别中的每一个，该方法通过使用该类别的评分模型来确定内容段与类别的相关性。 评分模型说明（i）内容片段中关键词集的存在，以及（ii）内容片段中关键词集的上下文。 对于几个类别中的每一个，当内容片段被确定为与该类别相关时，该方法标记内容片段。

公开(公告)号：US08761439B1

公开(公告)日：2014-06-24

申请号：US13217014

申请日：2011-08-24

Applicant: Rakesh Kumar ,  Supun Samarasekera ,  Taragay Oskiper

Inventor： Rakesh Kumar ,  Supun Samarasekera ,  Taragay Oskiper

IPC: G06K9/00

CPC classification number: G06T7/73

Abstract: An apparatus for providing three-dimensional pose comprising monocular visual sensors for providing images of an environment surrounding the apparatus, an inertial measurement unit (IMU) for providing gyroscope, acceleration and velocity information, collectively IMU information, a feature tracking module for generating feature tracking information for the images, and an error-state filter, coupled to the feature track module, the IMU and the one or more visual sensors, for correcting IMU information and producing a pose estimation based on at least one error-state model chosen according to the sensed images, the IMU information and the feature tracking information.

Abstract translation: 一种用于提供三维姿势的装置，包括用于提供围绕设备的环境的图像的单目视觉传感器，用于提供陀螺仪的惯性测量单元（IMU），集体IMU信息的加速度和速度信息，用于产生特征跟踪的特征跟踪模块 用于图像的信息以及耦合到特征轨道模块，IMU和一个或多个视觉传感器的误差状态滤波器，用于校正IMU信息，并且基于至少一个根据以下的选择的错误状态模型产生姿态估计： 感测图像，IMU信息和特征跟踪信息。

公开(公告)号：US08729695B2

公开(公告)日：2014-05-20

申请号：US13497611

申请日：2009-09-25

Applicant: Chirayarikathu Veedu Sankarapillai Premachandran ,  Rakesh Kumar ,  Nagarajan Ranganathan ,  Won Kyoung Choi ,  Ebin Liao ,  Yasuyuki Mitsuoka ,  Hiroshi Takahashi ,  Ryuta Mitsusue

Inventor： Chirayarikathu Veedu Sankarapillai Premachandran ,  Rakesh Kumar ,  Nagarajan Ranganathan ,  Won Kyoung Choi ,  Ebin Liao ,  Yasuyuki Mitsuoka ,  Hiroshi Takahashi ,  Ryuta Mitsusue

IPC: H01L23/12 ,  H01L21/00

CPC classification number: H01L21/6836 ,  B81B2207/092 ,  B81B2207/093 ,  B81B2207/097 ,  B81C2203/019 ,  H01L24/48 ,  H01L24/94 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2924/00014 ,  H01L2924/01012 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/09701 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/16195 ,  H01L2924/16235 ,  H01L2924/16315 ,  H01L2924/19041 ,  H01L2924/19107 ,  H01L2924/3011 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

Abstract: In an embodiment, a wafer level package may be provided. The wafer level package may include a device wafer including a MEMS device, a cap wafer disposed over the device wafer, at least one first interconnect disposed between the device wafer and the cap wafer and configured to provide an electrical connection between the device wafer and the cap wafer, and a conformal sealing ring disposed between the device wafer and the cap wafer and configured to surround the at least one first interconnect and the MEMS device so as to provide a conformally sealed environment for the at least one first interconnect and the MEMS device, wherein the conformal sealing ring may be configured to conform to a respective suitable surface of the device wafer and the cap wafer when the device wafer may be bonded to the cap wafer. A method of forming a wafer level package may also be provided.

Abstract translation: 在一个实施例中，可以提供晶片级封装。 晶片级封装可以包括包括MEMS器件的器件晶片，设置在器件晶片上的帽晶片，设置在器件晶片和帽晶片之间的至少一个第一互连，并且被配置为在器件晶片和晶片级封装之间提供电连接 帽状晶片和保形密封环，其设置在器件晶片和盖晶片之间并且被配置为围绕至少一个第一互连和MEMS器件，以便为至少一个第一互连和MEMS器件提供保形密封的环境 ，其中所述保形密封环可以被配置为当所述器件晶片可以结合到所述盖晶片时，使其符合所述器件晶片和所述盖晶片的相应合适的表面。 还可以提供一种形成晶片级封装的方法。

公开(公告)号：US08716532B2

公开(公告)日：2014-05-06

申请号：US13260806

申请日：2010-03-26

Applicant: Abhishek Sharma ,  Arun Kumar Sinha ,  Rakesh Kumar ,  Naina Sharma

Inventor： Abhishek Sharma ,  Arun Kumar Sinha ,  Rakesh Kumar ,  Naina Sharma

IPC: C07C39/215

CPC classification number: A61K36/482 ,  C07D317/54 ,  C07D333/16

Abstract: The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times.

Abstract translation: 本发明提供了制备一些新颖的多结构的2-或4-羟基取代的二苯乙烯的方法。 该方法提供一锅多组分方法，其中3-4步反应顺序即 缩合，脱羧和Heck偶联同时发生，导致所需产物的产率提高和反应时间缩短。

公开(公告)号：US08664199B2

公开(公告)日：2014-03-04

申请号：US13209399

申请日：2011-08-13

Applicant: Matthew Dowling ,  Srinivasa R. Raghavan ,  Rakesh Kumar

Inventor： Matthew Dowling ,  Srinivasa R. Raghavan ,  Rakesh Kumar

IPC: A61K31/722

CPC classification number: A61K31/724 ,  A61L15/28 ,  A61L15/42 ,  A61L26/0023 ,  A61L26/0061 ,  A61L26/0076 ,  A61L2300/232 ,  A61L2400/04

Abstract: A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.

Abstract translation: 疏水改性的生物聚合物与囊泡或细胞膜连接的凝胶化方法。 连接到囊泡或细胞膜上的疏水改性的生物聚合物的凝胶化通过将超分子如环糊精施加到胶凝组合物来逆转。 超分子破坏疏水改性生物聚合物与囊泡或细胞膜之间的相互作用，而不影响疏水性取代基所连接的膜或疏水改性聚合物的结构。 用于治疗包含疏水改性生物聚合物和超分子的伤口的试剂盒。 疏水改性的生物聚合物用于止血，超分子用于除去疏水改性的生物聚合物。

公开(公告)号：US20130303560A1

公开(公告)日：2013-11-14

申请号：US13980904

申请日：2012-01-31

Applicant: Rakesh Kumar ,  Robert S. Kerbel

Inventor： Rakesh Kumar ,  Robert S. Kerbel

IPC: A61K31/506 ,  A61K31/4745

CPC classification number: A61K31/506 ,  A61K31/4745 ,  A61K45/06 ,  C07D231/56 ,  A61K2300/00

Abstract: The present invention relates to a method of treating breast cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a breast cancer treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及治疗人类乳腺癌的方法和用于治疗的药物组合物。 特别地，该方法涉及一种乳腺癌治疗方法，其包括施用5 - [[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺 ，或其药学上可接受的盐，和（S）-10 - [（二甲基氨基）甲基] -4-乙基-4,9-二羟基-1H-吡喃并[3'，4'：6,7]吲哚并[ 2-b]喹啉-3,14-（4H，12H） - 二酮或其药学上可接受的盐。

公开(公告)号：US20130288984A1

公开(公告)日：2013-10-31

申请号：US13978765

申请日：2012-01-11

Applicant: Rakesh Kumar

Inventor： Rakesh Kumar

IPC: A61K31/4155 ,  A61K38/00

CPC classification number: A61K38/05 ,  A61K9/0019 ,  A61K31/4155 ,  A61K31/69 ,  A61K38/005 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering a proteasome inhibiting compound, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents, to a human in need thereof.