METHODS AND MICROFLUIDIC DEVICES FOR CHIROPTICAL DETECTION AND MUTATION ANALYSIS OF CANCER-ASSOCIATED EXTRACELLULAR VESICLES

    公开(公告)号:US20250147012A1

    公开(公告)日:2025-05-08

    申请号:US18579459

    申请日:2022-07-15

    Applicant: Yoon-Tae KANG

    Inventor: Yoon-Tae KANG

    Abstract: Microfluidic devices including a microfluidic channel with at least one surface having a plurality of chiral nanoparticles disposed thereon include a light-absorbing material (e.g., gold) and a targeting ligand capable of binding to a bioactive target analyte in a biological fluid sample. The bioactive target analyte can indicate presence of cancerous cells or mutated proteins in the biological fluid sample taken from a subject. Chiral gold nanoparticle layer-by-layer assembled onto a microfluidic device can rapidly isolate and profile cancer-associated exosomes directly from blood plasma using their own unique chiral signal. Exosomes from lung cancer patients can be distinguished from healthy donor exosomes by chiroptical spectroscopic signatures of biomolecular components. Mutation/deletion of epidermal growth factor receptor are also characterized, suggesting the possibility for in-depth mutation profiling in addition to cancer diagnostics. Methods of detecting bioactive target analytes and making the microfluidic devices are also provided.

    Skateboard capable of providing self-propulsive force

    公开(公告)号:US09868048B2

    公开(公告)日:2018-01-16

    申请号:US15053104

    申请日:2016-02-25

    Applicant: In Tae Kang

    Inventor: In Tae Kang

    Abstract: The skateboard capable of providing the self-propulsive force includes: a board main body; a center rotation portion which allows a user of the skateboard to change a direction of the skateboard with one foot put thereon; a first footrest portion which is provided on one side of the board main body with respect to the center portion and moves the board main body through a left and right reciprocating movement of the footrest; a second footrest portion which is provided on the other side of the board main body with respect to the center portion and moves the board main body through a left/right reciprocating movement of the footrest; and an elastic guide portion which is provided between the board main body and the wheel assemblies and guides left/right reciprocating movements of the support members.

    Clock signal processor and non-volatile memory device including the same
    83.
    发明授权
    Clock signal processor and non-volatile memory device including the same 有权
    时钟信号处理器和非易失性存储器件包括相同的

    公开(公告)号:US09536580B2

    公开(公告)日:2017-01-03

    申请号:US14803618

    申请日:2015-07-20

    CPC classification number: G11C7/222 G11C16/0483 G11C16/32

    Abstract: A clock signal processor includes a duty cycle corrector, a switch point calculator, and a multiplexer. The duty cycle corrector generates a second clock signal by modifying a duty cycle of a first clock signal. The switch point calculator activates a switch signal at an end of a latency period in which a read command is provided to a non-volatile memory device and an invalid data is read from the non-volatile memory device. The multiplexer outputs one of the first and second clock signals as a third clock signal based on the switch signal.

    Abstract translation: 时钟信号处理器包括占空比校正器,开关点计算器和多路复用器。 占空比校正器通过修改第一时钟信号的占空比来产生第二时钟信号。 开关点计算器在等待时间结束时激活开关信号,其中将读取命令提供给非易失性存储器件,并且从非易失性存储器件读取无效数据。 多路复用器基于开关信号将第一和第二时钟信号之一输出为第三时钟信号。

    Field emission x-ray tube apparatus for facilitating cathode replacement
    84.
    发明授权
    Field emission x-ray tube apparatus for facilitating cathode replacement 有权
    用于促进阴极更换的场发射X射线管装置

    公开(公告)号:US08942352B2

    公开(公告)日:2015-01-27

    申请号:US13406545

    申请日:2012-02-28

    CPC classification number: H01J35/065 H01J35/14

    Abstract: The present disclosure relates to a field emission X-ray tube apparatus for facilitating cathode replacement, and more particularly, to a field emission X-ray tube apparatus for facilitating cathode replacement in which gates and cathodes are easily arranged through a joining member and a rotation preventing guide when gates and insulating spacers are rotated and joined with the cathodes while the cathodes and respective gates maintain electrical insulation, thereby easily replacing the cathodes.

    Abstract translation: 本发明涉及一种用于促进阴极替换的场致发射X射线管装置,更具体地,涉及一种用于促进阴极替换的场发射X射线管装置,其中栅极和阴极易于通过接合构件布置并且旋转 当栅极和绝缘间隔物旋转并与阴极接合时,防止引导,同时阴极和相应的栅极保持电绝缘,从而容易地更换阴极。

    BENEFIT PROMOTION ADVERTISING IN AN AUGMENTED REALITY ENVIRONMENT
    85.
    发明申请
    BENEFIT PROMOTION ADVERTISING IN AN AUGMENTED REALITY ENVIRONMENT 审中-公开
    受益于现实环境中的优势促销

    公开(公告)号:US20140025481A1

    公开(公告)日:2014-01-23

    申请号:US13553885

    申请日:2012-07-20

    CPC classification number: G06Q30/0244 G06Q30/0241 G06Q30/0276

    Abstract: Embodiments described herein provide approaches for benefit promotion advertising in an augmented reality (AR) environment. Specifically, users are presented with an advertisement overlay generated for a video sequence from a mobile device. The advertisement overlay comprises a set of AR objects, and an incentive to the user to interact with the AR objects of the advertisement overlay. Responses from the user are recognized, and a benefit is provided to the user based on the response to the incentive. As such, advertisement campaigns in the AR environment are made more appealing to the user and, consequently, more effective for the advertiser.

    Abstract translation: 本文描述的实施例提供了在增强现实(AR)环境中的益处促销广告的方法。 具体地,向用户呈现由移动设备为视频序列生成的广告覆盖。 广告覆盖包括一组AR对象,并且激励用户与广告覆盖的AR对象进行交互。 识别用户的响应,并且基于对激励的响应向用户提供益处。 因此,AR环境中的广告活动对用户更具吸引力,因此对广告商更有效。

    Packet decoding method and apparatus for digital broadcast system
    86.
    发明授权
    Packet decoding method and apparatus for digital broadcast system 有权
    用于数字广播系统的分组解码方法和装置

    公开(公告)号:US08570878B2

    公开(公告)日:2013-10-29

    申请号:US12876575

    申请日:2010-09-07

    CPC classification number: H04N21/4382 H04N21/434 H04N21/6131

    Abstract: A packet decoding method and apparatus of a digital broadcast system is provided for improving decoding performance by reordering blocks to be decoded and adjusting a number of decoding iterations of each block. A packet decoding method of the present invention includes measuring Signal-to-Noise Ratios (SNRs) of individual packets within a slot, determining a decoding order of the packets according to the SNRs, and decoding the packets in the decoding order. The decoding method and apparatus of a digital broadcast system according to the present invention performs decoding on the packets having the highest channel estimation performance first with reduced number of decoding iterations and reallocates the saved number of decoding iterations to remaining packets having relatively low channel estimation performance, thereby improving the decoding performance of the received packets.

    Abstract translation: 提供了一种数字广播系统的分组解码方法和装置,用于通过重新排序待解码块并调整每个块的解码迭代次数来提高解码性能。 本发明的分组解码方法包括测量时隙内的各个分组的信噪比(SNR),根据SNR确定分组的解码顺序,并以解码顺序解码分组。 根据本发明的数字广播系统的解码方法和装置首先对具有最低信道估计性能的分组进行解码,并且将经解码迭代次数重新分配给具有较低信道估计性能的剩余分组 从而提高接收到的分组的解码性能。

    Method and apparatus for reducing peak to average power ratio using peak windowing
    87.
    发明授权
    Method and apparatus for reducing peak to average power ratio using peak windowing 有权
    使用峰值窗口降低峰均功率比的方法和装置

    公开(公告)号:US08548092B2

    公开(公告)日:2013-10-01

    申请号:US13004271

    申请日:2011-01-11

    CPC classification number: H04L27/2624

    Abstract: A method and apparatus for reducing a Peak to Average Power Ratio (PAPR) using peak windowing is provided. In the apparatus, an absolute value calculator calculates an absolute value of an input signal, a subtractor subtracts a predetermined clipping threshold level from the absolute value, a smoothing unit performs smoothing on the subtracted signal according to a predetermined smoothing scheme and outputs a first smoothed signal, an adder adds the first smoothed signal to the clipping threshold level, an inverse calculator outputs a second smoothed signal by multiplying the clipping threshold level by an inverse of the added signal, and a multiplier outputs a final PAPR-reduced signal by multiplying the input signal by the second smoothed signal. The method and apparatus address an overcompensation problem while processing signals having a large bandwidth and a high data rate without delay, thereby minimizing the clipping influences on Bit Error Rate (BER) and Adjacent Channel Leakage Ratio (ACLR) performances.

    Abstract translation: 提供了一种使用峰值窗口降低峰均功率比(PAPR)的方法和装置。 在设备中,绝对值计算器计算输入信号的绝对值,减法器根据绝对值减去预定的限幅阈值电平,平滑单元根据预定的平滑方案对减法信号进行平滑处理,并输出第一个平滑 信号,加法器将第一平滑信号与削波阈值电平相加,逆计算器通过将削波阈值电平乘以相加信号的倒数来输出第二平滑信号,乘法器将最终的PAPR降低信号乘以 输入信号由第二平滑信号。 该方法和装置在不延迟地处理具有大带宽和高数据速率的信号的同时解决过度补偿问题,从而最小化对误码率(BER)和相邻信道泄漏比(ACLR)性能的削波影响。

    Field emission device
    88.
    发明授权
    Field emission device 有权
    场发射装置

    公开(公告)号:US08519627B2

    公开(公告)日:2013-08-27

    申请号:US12502810

    申请日:2009-07-14

    Abstract: Provided is a field emission device having a simple structure and capable of pulse driving and local dimming. The field emission device turns a current flowing from each cathode electrode block on or off in response to a switching control signal having a very low voltage ranging from 0 to 5 V while a constant voltage is applied to an anode electrode and a gate electrode to control a field emission current. Compared with a conventional field emission device, the field emission device having a simple structure is capable of pulse driving and local dimming without using a separate pulse driving high voltage power source.

    Abstract translation: 提供具有简单结构并能够进行脉冲驱动和局部调光的场发射器件。 场致发射器件响应于具有0至5V的非常低的电压的开关控制信号而使来自每个阴极电极块的电流开启或关闭,同时将恒定电压施加到阳极电极和栅电极以控制 场发射电流。 与传统的场致发射器件相比,具有简单结构的场发射器件能够在不使用单独的脉冲驱动高压电源的情况下进行脉冲驱动和局部调光。

    Color variable field emission device
    90.
    发明授权
    Color variable field emission device 有权
    彩色可变场发射装置

    公开(公告)号:US08264151B2

    公开(公告)日:2012-09-11

    申请号:US12550814

    申请日:2009-08-31

    CPC classification number: H01J29/98 G09G3/22

    Abstract: A field emission device having a simple structure and capable of readily changing emission colors of light by adjusting emission intensity of red, green and blue light is provided. In the field emission device, current that flows into each cathode electrode block is adjusted according to a very low control pulse signal of 0 to 5 V with a predetermined voltage applied to an anode electrode and a gate electrode over time, so that emission intensities of red, green and blue are individually adjusted. Therefore, the current that flows into each cathode electrode block is adjusted in a simple manner using a control pulse signal of a low level without a separate pulse driving high-voltage power supply, so that emission intensities of red, green and blue can be arbitrarily adjusted and emission colors of the field emission device can be readily changed.

    Abstract translation: 提供了具有简单结构并且能够通过调节红,绿和蓝光的发射强度来容易地改变发光颜色的场发射器件。 在场发射装置中,流过各阴极电极块的电流根据非常低的0〜5V的控制脉冲信号进行调整,并且随着时间推移施加到阳极电极和栅电极的规定电压,发光强度 红色,绿色和蓝色分别进行调整。 因此,流入各阴极电极块的电流使用低电平的控制脉冲信号以单独的脉冲驱动高压电源的方式进行调整,从而红色,绿色和蓝色的发光强度可以任意调整 可以容易地改变场致发射装置的调整和发射颜色。

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