公开(公告)号：US11426818B2

公开(公告)日：2022-08-30

申请号：US16537361

申请日：2019-08-09

Applicant: The Research Foundation for the State University of new York

Inventor： Scott N. Schiffres ,  Arad Azizi

IPC: B33Y10/00 ,  B23K26/342 ,  B33Y70/00 ,  H01L21/283 ,  H01L23/367 ,  H01L23/373 ,  B33Y80/00 ,  F28F21/02 ,  B32B7/12 ,  F28D15/00 ,  B32B15/01 ,  F28F21/00 ,  F28F21/04 ,  F28F21/08

Abstract: A technique to additively print onto a dissimilar material, especially ceramics and glasses (e.g., semiconductors, graphite, diamond, other metals) is disclosed herein. The technique enables manufacture of heat removal devices and other deposited structures, especially on heat sensitive substrates. It also enables novel composites through additive manufacturing. The process enables rapid bonding, orders-of-magnitude faster than conventional techniques.

公开(公告)号：US20220251566A1

公开(公告)日：2022-08-11

申请号：US17622355

申请日：2020-06-25

Applicant: The Research Foundation for The State University of New York

Inventor： Sergey V. DORONIN ,  Irina A. POTAPOVA ,  Ira S. COHEN

IPC: C12N15/113 ,  C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  A61K35/28

Abstract: The present disclosure is directed to genetically modified carrier/donor cells that are engineered to be resistant to its oligonucleotide payload, and methods of delivering an oligonucleotide into a target cell. The disclosure is also directed to methods of treating cancer using the engineered carrier cells of the disclosure. An aspect of this disclosure is directed to engineering carrier cells to be resistant to the detrimental effects of an oligonucleotide.

公开(公告)号：US20220162254A1

公开(公告)日：2022-05-26

申请号：US17542090

申请日：2021-12-03

Applicant: The Research Foundation For The State University Of New York

Inventor： William G. Kerr ,  John D. Chisholm

IPC: C07J1/00 ,  C07J41/00

Abstract: The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

公开(公告)号：US20220158819A1

公开(公告)日：2022-05-19

申请号：US17438662

申请日：2020-03-13

Applicant: The Research Foundation for The State University of New York

Inventor： Emre SALMAN ,  Milutin STANACEVIC ,  Yasha KARIMI ,  Tutu WAN ,  Yuanfei HUANG

IPC: H04L9/06 ,  H04L9/08

Abstract: A processing unit and a method of operating a processing unit. In an embodiment, the processing unit comprises a SIMON block cipher for transforming plaintext data into encrypted data. A key expansion module generates and outputs one or more encryption keys; and the key expansion module includes a first series of adiabatic registers for holding key generation data values, and for using adiabatic switching to transmit the key generation data values through the first series of adiabatic registers. A round function module receives the plaintext data and the one or more encryption keys, encrypts the plaintext data to generate the encrypted data, and outputs the encrypted data; and the round function module includes a second series of adiabatic registers for holding encryption data, and for using adiabatic switching to transmit the encryption data through the second series of adiabatic registers.

公开(公告)号：US20220123293A1

公开(公告)日：2022-04-21

申请号：US17511522

申请日：2021-10-26

Applicant: Brookhaven Science Associates, LLC ,  The Research Foundation For The State University of New York

Inventor： Esther Sans Takeuchi ,  Altug S. Poyraz ,  Kenneth James Takeuchi ,  Amy Catherine Marschilok

IPC: H01M4/505 ,  H01M4/131 ,  H01M10/052 ,  H01M10/54 ,  H01M4/48 ,  H01M4/62 ,  C01G45/12

Abstract: A binder-free, self-supporting electrode including an electrochemically active material in the absence of a binder and a current collector is claimed. The electrochemically active material is a self-supporting transition metal oxide. A method of regenerating the electrode to restore capacity of the electrode is also claimed.

公开(公告)号：US11310883B2

公开(公告)日：2022-04-19

申请号：US17321057

申请日：2021-05-14

Applicant: The Research Foundation for The State University of New York

Inventor： Pritam Das

IPC: H05B45/10 ,  H05B45/382 ,  H05B45/38 ,  H02M1/08 ,  H05B45/355 ,  H02M3/335

Abstract: An apparatus method for driving light emitting diodes (LEDs), comprising: receiving an alternating current input; producing a DC current having a voltage with an AC-DC boost power-factor correction stage, having a variable-frequency operation, and a set of switches controlled in dependence on the voltage to limit a peak LED current; and producing an LED drive current with a DC-DC power conversion stage having a set of switches to selectively pulse-width modulate the LEDs to control a brightness, wherein the set of switches in the AC-DC boost power-factor correction stage and the set of switches in the DC-DC power conversion stage are each controlled to switch at zero current.

公开(公告)号：US20220092375A1

公开(公告)日：2022-03-24

申请号：US17543122

申请日：2021-12-06

Applicant: The Research Foundation for The State University of New York

Inventor： Kanad Ghose

IPC: G06K19/07 ,  G06K19/077

Abstract: A method for controlling a data center, comprising a plurality of server systems, each associated with a cooling system and a thermal constraint, comprising: a concurrent physical condition of a first server system; predicting a future physical condition based on a set of future states of the first server system; dynamically controlling the cooling system in response to at least the input and the predicted future physical condition, to selectively cool the first server system sufficient to meet the predetermined thermal constraint; and controlling an allocation of tasks between the plurality of server systems to selectively load the first server system within the predetermined thermal constraint and selectively idle a second server system, wherein the idle second server system can be recruited to accept tasks when allocated to it, and wherein the cooling system associated with the idle second server system is selectively operated in a low power consumption state.

公开(公告)号：US11262309B2

公开(公告)日：2022-03-01

申请号：US16509372

申请日：2019-07-11

Applicant: Advanced Cytometry Instrumentation Systems, LLC ,  The Research Foundation for The State University of New York

Inventor： Andrey N. Kuzmin ,  Artem Pliss ,  Paras N. Prasad

IPC: G01N21/65 ,  G01N33/50 ,  G01J3/44 ,  G01N33/92

Abstract: Methods for determining lipid composition. The lipid(s) in a composition may include phospholipids. A method may be carried out on an individual cell. A method may compare the Raman spectrum of the portion of a cell with a model Raman spectrum, which does not include the lipid component, where the difference between the Raman spectrum of the portion of the cell and the model Raman spectrum correlates to the lipid composition in the portion of the cell in the portion of the cell). A method may be used to diagnose a disease such as, for example, cancers, including breast cancer, prostate cancer, and via the presence and/or absence of abnormal or damaged cells in an individual.

公开(公告)号：US11261208B2

公开(公告)日：2022-03-01

申请号：US16615024

申请日：2018-05-21

Applicant: The Research Foundation for The State University of New York

Inventor： Janet R. Morrow ,  Eric M. Snyder ,  Didar Asik

IPC: C07F15/02 ,  A61K49/08 ,  A61K49/10 ,  A61K49/12 ,  A61K49/14

Abstract: Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron coordinated compounds may exhibit a negative redox potential (e.g., relative to a normal hydrogen electrode at a biologically relevant pH, for example, a pH of 6.5-7.5). The compounds can be used as MRI contrast agents.

公开(公告)号：US20220003779A1

公开(公告)日：2022-01-06

申请号：US17367141

申请日：2021-07-02

Applicant: The Research Foundation for the State University of New York

Inventor： Nathaniel Cady

IPC: G01N33/68 ,  G01N21/64

Abstract: The present disclosure relates to a method for the simultaneous qualitative and quantitative analysis of a plurality of biomarkers contained in a sample, including: capturing one or more biomarkers on a substrate configured to bind a plurality of biomarkers to a plurality of binding sites, wherein binding sites bind at least two biomarkers, and wherein when one or more biomarkers are present forming one or more bound biomarkers-of-interest; contacting the one or more bound biomarkers-of-interest with one or more fluorescent binding partners to form one or more fluorescent complexes; contacting the substrate with a source of collimated, polarized light, wherein the source of collimated polarized light emits light at a predetermined wavelength for transferring energy to surface plasmons and excite fluorescence of the one or more fluorescent complexes; and detecting emission light of fluorescent complexes; and determining the type and/or quantity of plurality of biomarkers.